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KCC2 Produkte

(Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))

Kategorien

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].

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Ausgewählte KCC2 Kategorien

KCC2 Antikörper

High quality antibodies with extensive validation data.

KCC2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene KCC2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Rat
Applikation WB, IHC, IP, IF, ICC
Validierungen
  • (4)
Kat. Nr. ABIN1027708
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Mouse, Rat
Applikation IHC, IF
Validierungen
  • (3)
Kat. Nr. ABIN7075650
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC (p)
Validierungen
  • (3)
Kat. Nr. ABIN652057
Menge 400 μL
Datenblatt Datenblatt

Empfohlene KCC2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6210805
Menge 96 tests
Datenblatt Datenblatt

Empfohlene KCC2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3087605
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3087606
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3127245
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren KCC2 Produkten

Dumon, Diabira, Chudotvorova, Bader, Sahin, Zhang, Porcher, Wayman, Medina, Gaiarsa: "The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice." in: eLife, Vol. 7, (2019) (PubMed).

Kwon, Neupane, Shin, Gwon, Yin, Shin, Shin, Hong, Park, Yi, Kim, Kang: "Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats." in: Experimental neurobiology, Vol. 28, Issue 4, pp. 529-536, (2019) (PubMed).

Huang, Grau: "Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain." in: Experimental neurology, Vol. 306, pp. 105-116, (2019) (PubMed).

Mahadevan, Khademullah, Dargaei, Chevrier, Uvarov, Kwan, Bagshaw, Pawson, Emili, De Koninck, Anggono, Airaksinen, Woodin: "Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition." in: eLife, Vol. 6, (2018) (PubMed).

Stödberg, McTague, Ruiz, Hirata, Zhen, Long, Farabella, Meyer, Kawahara, Vassallo, Stivaros, Bjursell, Stranneheim, Tigerschiöld, Persson, Bangash, Das, Hughes, Lesko, Lundeberg, Scott, Poduri et al.: "Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures. ..." in: Nature communications, Vol. 6, pp. 8038, (2015) (PubMed).

Mahadevan, Dargaei, Ivakine, Hartmann, Ng, Chevrier, Ormond, Nothwang, McInnes, Woodin: "Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures." in: Frontiers in cellular neuroscience, Vol. 9, pp. 368, (2015) (PubMed).

Toda, Ishida, Kiyama, Yamashita, Lee: "Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity." in: PLoS ONE, Vol. 9, Issue 12, pp. e114328, (2015) (PubMed).

He, Nomura, Xu, Contractor: "The developmental switch in GABA polarity is delayed in fragile X mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 2, pp. 446-50, (2014) (PubMed).

Markkanen, Karhunen, Llano, Ludwig, Rivera, Uvarov, Airaksinen: "Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS." in: The Journal of comparative neurology, Vol. 522, Issue 8, pp. 1897-914, (2014) (PubMed).

Law, Paquet, Kania: "Emergence of motor circuit activity." in: PLoS ONE, Vol. 9, Issue 4, pp. e93836, (2014) (PubMed).

Synonyme und alternative Namen zu KCC2

solute carrier family 12 member 5 (SLC12A5), solute carrier family 12 member 5 (Slc12a5), solute carrier family 12, member 5 (Slc12a5), Kcc2, KCC2, mKIAA1176

Bezeichner auf Proteinebene für KCC2

  • solute carrier family 12 (potassium/chloride transporter), member 5
  • K-Cl cotransporter 2
  • electroneutral potassium-chloride cotransporter 2
  • furosemide-sensitive K-Cl cotransporter
  • neuronal K-Cl cotransporter
  • neuronal-specific K-Cl cotransporter
  • rKCC2
  • solute carrier family 12 member 5
  • solute carrier family 12, member 5
  • erythroid K-Cl cotransporter 2
  • hKCC2
  • mKCC2
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