Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

KCC2 Antikörper (AA 932-1043) (PE)

SLC12A5 Reaktivität: Ratte WB, IHC, IP, IF, ICC Wirt: Maus Monoclonal S1-12 PE
Produktnummer ABIN2484122
  • Target Alle KCC2 (SLC12A5) Antikörper anzeigen
    KCC2 (SLC12A5) (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))
    Bindungsspezifität
    • 12
    • 12
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 932-1043
    Reaktivität
    • 29
    • 25
    • 9
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 34
    • 14
    Maus
    Klonalität
    • 34
    • 14
    Monoklonal
    Konjugat
    • 25
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KCC2 Antikörper ist konjugiert mit PE
    Applikation
    • 41
    • 32
    • 21
    • 14
    • 12
    • 11
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~140 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 932-1043 corresponding to rat KCC2
    Klon
    S1-12
    Isotyp
    IgG2a
    Top Product
    Discover our top product SLC12A5 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • IHC (1:300)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN2484122 was sufficient for detection of KCC2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    KCC2 (SLC12A5) (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))
    Andere Bezeichnung
    KCC2 (SLC12A5 Produkte)
    Synonyme
    Kcc2 antikoerper, KCC2 antikoerper, mKIAA1176 antikoerper, solute carrier family 12 member 5 antikoerper, solute carrier family 12, member 5 antikoerper, SLC12A5 antikoerper, Slc12a5 antikoerper
    Hintergrund
    KCC2 is a member of the cation-chloride cotransporter gene family (1). It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain (2, 3). KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord (4). Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior.
    Gen-ID
    171373
    NCBI Accession
    NP_599190
    UniProt
    Q63633
Sie sind hier:
Kundenservice