KCC2 Antikörper (pSer940)

Produktnummer ABIN6254065

Produktdetails anti-KCC2 Antikörper

Target: KCC2 (SLC12A5) (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))

Bindungsspezifität: pSer940

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Ratte (Rattus)

Homologie: bovine, canine, human, mouse, non-human primate

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser940 conjugated to KLH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Referenzen für anti-KCC2 Antikörper (ABIN6254065)

Kwon, Neupane, Shin, Gwon, Yin, Shin, Shin, Hong, Park, Yi, Kim, Kang: "Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats." in: Experimental neurobiology, Vol. 28, Issue 4, pp. 529-536, (2019) (PubMed).

Huang, Grau: "Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain." in: Experimental neurology, Vol. 306, pp. 105-116, (2019) (PubMed).

Mahadevan, Khademullah, Dargaei, Chevrier, Uvarov, Kwan, Bagshaw, Pawson, Emili, De Koninck, Anggono, Airaksinen, Woodin: "Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition." in: eLife, Vol. 6, (2018) (PubMed).

Mahadevan, Dargaei, Ivakine, Hartmann, Ng, Chevrier, Ormond, Nothwang, McInnes, Woodin: "Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures." in: Frontiers in cellular neuroscience, Vol. 9, pp. 368, (2015) (PubMed).

Toda, Ishida, Kiyama, Yamashita, Lee: "Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity." in: PLoS ONE, Vol. 9, Issue 12, pp. e114328, (2015) (PubMed).

Details zu KCC2

Target: KCC2 (SLC12A5) (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))

Andere Bezeichnung: KCC2 (SLC12A5 Produkte)

Synonyme: Kcc2 antikoerper, KCC2 antikoerper, mKIAA1176 antikoerper, solute carrier family 12 member 5 antikoerper, solute carrier family 12, member 5 antikoerper, SLC12A5 antikoerper, Slc12a5 antikoerper

Molekulargewicht: '135 kDa

Gen-ID: 171373

UniProt: Q63633