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The protein encoded by SCARB2 is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes.
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The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2
, CD36 antigen-like 2
, lysosome membrane protein 2
, scavenger receptor class B, member 2
, lysosome membrane protein 2-like
, putative lysosomal integral membrane protein II
, 85 kDa lysosomal membrane sialoglycoprotein
, 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2
, CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II)
, LIMP II
, lysosome membrane protein II