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The protein encoded by SMARCB1 is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. Zusätzlich bieten wir Ihnen SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Proteine (9) und SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 131 products:
Human Monoclonal SMARCB1 Primary Antibody für IF, WB - ABIN968742
Bruder, Dumanski, Kedra: The mouse ortholog of the human SMARCB1 gene encodes two splice forms. in Biochemical and biophysical research communications 1999
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Human Monoclonal SMARCB1 Primary Antibody für IF, WB - ABIN968741
Guidi, Sands, Zambrowicz, Turner, Demers, Webster, Smith, Imbalzano, Jones: Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. in Molecular and cellular biology 2001
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Human Polyclonal SMARCB1 Primary Antibody für IF (p), IHC (p) - ABIN762566
McAndrew, Gjidoda, Tagore, Miksanek, Floer: Chromatin Remodeler Recruitment during Macrophage Differentiation Facilitates Transcription Factor Binding to Enhancers in Mature Cells. in The Journal of biological chemistry 2016
Human Monoclonal SMARCB1 Primary Antibody für IHC (p), ELISA - ABIN562912
Scurr, Pupo, Becker, Lai, Schrama, Haferkamp, Irvine, Scolyer, Mann, Becker, Kefford, Rizos: IGFBP7 is not required for B-RAF-induced melanocyte senescence. in Cell 2010
Human Polyclonal SMARCB1 Primary Antibody für ICC, IF - ABIN252863
Young, Jacks: Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. in Proceedings of the National Academy of Sciences of the United States of America 2010
Human Monoclonal SMARCB1 Primary Antibody für WB - ABIN393962
Wu, Ho, Lin, Lin: Rhabdoid papillary meningioma: a clinicopathologic case series study. in Neuropathology : official journal of the Japanese Society of Neuropathology 2011
Human Polyclonal SMARCB1 Primary Antibody für ICC, IF - ABIN4354923
Singh, Archer: Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. in Nucleic acids research 2014
Human Polyclonal SMARCB1 Primary Antibody für WB - ABIN2778302
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
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Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas.
Of the 34 undifferentiated endometrial carcinomas examined, 17 (50%) exhibited SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) complex inactivation, with 11 tumors showing complete loss of both ARID1A (zeige ARID1A Antikörper) and ARID1B (zeige ARID1B Antikörper), 5 showing complete loss of BRG1 (zeige SMARCA4 Antikörper) and 1 showing complete loss of INI1. Ten of the remaining 17 undifferentiated carcinomas showed the following alterations: 5 tumors (15%) showed loss of ARID1A (zeige ARID1A Antikörper) only with intact ARID1B (zeige ARID1B Antikörper), BRG1 (zeige SMARCA4 Antikörper), and INI1 expression.
Our study, the first comprehensive analysis of RMC, supports a pivotal role for SMARCB1 in its development.
HRAS (zeige HRAS Antikörper) mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 (zeige PLAG1 Antikörper) and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 (zeige PLAG1 Antikörper) and HMGA2 correlates with the presence of TP53 (zeige TP53 Antikörper), FBXW7 (zeige FBXW7 Antikörper) mutations, or SMARCB1 deletion.
Intronic hotspot variant of SMARCB1 was identified in atypical teratoid and rhabdoid tumors of two patients. This cryptic variant was absent in the germline DNA of both patients.
These highly mobile and invasive cells no longer depend on KRAS signaling and rely on the aberrant activation of mesenchymal programs regulated by the chromatin remodeling factor (zeige ASH1L Antikörper) SMARCB1. Mouse models showed that Smarcb1 ablation could intensify cancer spread; conversely, restoring Smarcb1 slowed tumor growth and restored the cells to their less invasive, epithelial form
BAF57 (zeige SMARCE1 Antikörper), BAF60a (zeige SMARCD1 Antikörper) and SNF5 might act as novel pro-senescence factors in both normal and tumor human skin cells
Low SNF5 expression is associated with Hepatocellular Carcinoma.
SMARCB1 is required for widespread BAF (zeige BANF1 Antikörper) complex-mediated activation of enhancers and bivalent promoters.
Interactions have been indicated between SMARCB1/INI1 protein and key proteins in various pathways related to tumor proliferation and progression.
Data show that early Smarcb1 loss causes rhabdoid tumors whereas loss at later stages combined with Nf2 (zeige NF2 Antikörper) gene inactivation causes shwannomas.
The occurrence of intracranial rhabdoid tumours depends on control of Smarcb1 inactivation.
These results support recent findings regarding the effectivity of EGFR (zeige EGFR Antikörper) inhibitors in hindering the proliferation of human MRT cells and demonstrate that activation of EGFR (zeige EGFR Antikörper) signaling in Rhabdoid tumors is SMARCB1 dependent.
these findings uncover a novel role for Snf5 in oligodendrocyte generation and survival, and they offer evidence of the first genetically engineered mouse model for AT/RT in the CNS.
This study show here that loss of Smarcb1 and Smarca4 (zeige SMARCA4 Antikörper) leads to severe proliferation deficits of granule neuron precursors and a hypoplastic cerebellum.
results show that Smarcb1 is required for transcriptional activation of Igfbp7 (zeige IGFBP7 Antikörper) and show that re-introduction of Igfbp7 (zeige IGFBP7 Antikörper) alone can hinder tumor development; results define a novel mechanism for Smarcb1-mediated tumorigenesis
We find that inactivation of either Brg1 (zeige SMARCA4 Antikörper) or Smarcb1 leads to disruptions of specific nucleosome patterning combined with a loss of overall nucleosome occupancy at a large number of promoters, regardless of their association with CpG islands.
SNF5 is a key mediator of Hedgehog (zeige SHH Antikörper) signaling and that aberrant activation of GLI1 (zeige GLI1 Antikörper) is a previously undescribed targetable mechanism contributing to the growth of malignant rhabdoid tumor cells.
Loss of the SNF5 tumor suppressor leads to elevated expression of the Polycomb (zeige CBX2 Antikörper) gene EZH2 (zeige EZH2 Antikörper).
SNF5 knockdown inhibits p53 (zeige TP53 Antikörper) translation by eIF4E (zeige EIF4E Antikörper) and replacement of eIF4E (zeige EIF4E Antikörper) in SNF5 knockdown cells restores p53 (zeige TP53 Antikörper) expression and cell survival
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
, matrix metalloproteinase 11 (stromelysin 3)
, BRG1-associated factor 47
, SNF5 homolog
, integrase interactor 1 protein
, malignant rhabdoid tumor suppressor
, sucrose nonfermenting, yeast, homolog-like 1
, SWI/SNF-related matrix associated protein