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RFX2 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. Zusätzlich bieten wir Ihnen Regulatory Factor X 2 Antikörper (40) und Regulatory Factor X 2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Rfx2 coordinates multiple, distinct gene expression programs in multi-ciliated epithelial cells, regulating genes that control cell movement, ciliogenesis, and cilia function.
Taken together, this study suggests ciliogenic RFX transcription factors regulate FGF-1B promoter activity and the maintenance of F1BGFP(+) NSPCs and GBM-SCs.
We show binding of RFX proteins to an evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these proteins are responsible for ALMS1 transcription during growth arrest
novel role for the RFX family of transcription factors as modulators of Ras signalling in epithelial cells.
RFX2 plays a major and specific function in spermiogenesis.
Data show that that Rfx2 is expressed in motile cilia in mouse and zebrafish embryos
RFX2 is potentially an important transcriptional regulator in pachytene spermatocytes; Rfx2 itself is a good candidate to be regulated by A-MYB, which is essential for meiotic progression.
RFX2 may play roles in haploid cells during mouse spermatogenesis
RFX2 is strongly expressed in pachytene spermatocytes, remains high in early round spermatids, and declines only in advance of nuclear condensation. Maximum expression correlates well with the appearance of H1t.
Rfx2 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Data show that knockdown of Rfx2 results in cilia-defective embryonic phenotypes.
Data show that that Rfx2 is expressed in motile cilia in mouse and zebrafish embryos.
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.
DNA binding protein RFX2
, DNA-binding protein RFX2
, HLA class II regulatory factor RFX2
, regulatory factor X 2
, trans-acting regulatory factor 2
, regulatory factor X2
, Regulatory factor X 2