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Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis.
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Chronophin has a role in coordinating cell leading edge dynamics by controlling active cofilin (zeige CFL1 Proteine) levels
Splicing of SH3BP1 (zeige SH3BP1 Proteine) and CIN gene loci produces the novel brain specific (zeige CALY Proteine) splice variant BGIN.
analysis of pyridoxal phosphatase cloning, expression and tissue distribution
We report the biochemical isolation of chronophin (CIN), a unique cofilin (zeige CFL1 Proteine)-activating phosphatase of the haloacid dehalogenase (HAD) superfamily and an important novel regulator of cofilin (zeige CFL1 Proteine)-mediated actin reorganization.
Results suggest that the transduction of the PEP-1-PLPP fusion protein can be one mode of PLP (zeige PLP1 Proteine) level regulation, and to replenish this enzyme in the various neurological disorders related to vitamin B(6).
Study demonstrates the ATP-sensitive interaction of the cofilin (zeige CFL1 Proteine) phosphatase chronophin (CIN) with the chaperone hsp90 (zeige HSP90 Proteine) to form a biosensor that mediates cofilin (zeige CFL1 Proteine)/actin rod formation.
Results provided novel evidence that PLPP is involved in controlling dendritic spine as well as synaptic plasticity. It showed also for the first time the role of PLPP in GluN functionality via regulation of GluN2A (zeige GRIN2A Proteine) interaction with postsynaptic proteins. These findings suggest that PLPP/CIN may play an important role in information storage and recall capacity, which manifests as a learning memory.
Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP (zeige C3 Proteine) coordination.
Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003
, pyridoxal phosphate phosphatase
, pyridoxal phosphatase
, reg I binding protein I
, reg I-binding protein 1