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Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. Zusätzlich bieten wir Ihnen PEAK1 Antikörper (52) und und viele weitere Produktgruppen zu diesem Protein an.
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the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9.
Findings indicate that eIF5A (zeige EIF5 Proteine)-PEAK1-YAP (zeige YAP1 Proteine) signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity.
report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta (zeige TGFB1 Proteine) receptors and integrin/Src (zeige SRC Proteine)/MAPK (zeige MAPK1 Proteine) pathways and that PEAK1 is an important molecular regulator of TGFbeta (zeige TGFB1 Proteine)-induced tumor progression and metastasis in breast cancer
this regard, we have demonstrated that PEAK1 is necessary for TGFbeta (zeige TGFB1 Proteine) to induce ZEB1-mediated EMT (zeige ITK Proteine) in the context of fibronectin (zeige FN1 Proteine)/ITGB3 (zeige ITGB3 Proteine) activation.
Suggest that loss of PEAK1/E-cadherin (zeige CDH1 Proteine) may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition.
eIF5A (zeige EIF5 Proteine) proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis.
results define a novel signaling pathway in basal breast cancer involving Lyn (zeige LYN Proteine) and SgK269 that offers clinical opportunities for therapeutic intervention
phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover
Here, we report that the novel tyrosine kinase (zeige TXK Proteine) PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN).
Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms
Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN (By similarity).
pseudopodium enriched atypical kinase
, pseudopodium-enriched atypical kinase 1
, sugen kinase 269
, tyrosine-protein kinase SgK269
, NKF3 kinase family member