Pseudopodium-Enriched Atypical Kinase 1 Proteine (PEAK1)

Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. Zusätzlich bieten wir Ihnen PEAK1 Antikörper (56) und PEAK1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PEAK1 79834 Q9H792
Maus PEAK1 PEAK1 244895 Q69Z38
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Top PEAK1 Proteine auf

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
Baculovirus infected Insect Cells Human GST tag   50 μg Anmelden zum Anzeigen 10 bis 12 Tage
Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage

PEAK1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,

Weitere Proteine zu Pseudopodium-Enriched Atypical Kinase 1 (PEAK1) Interaktionspartnern

Human Pseudopodium-Enriched Atypical Kinase 1 (PEAK1) Interaktionspartner

  1. PEAK1's kinase cleft is occluded, and its newly identified SHED region may promote an unexpected dimerization mode. Similarities of PEAK1 with the active kinase PINK1 may reclassify the latter as a member of the new kinase family 3 group.

  2. the critical role of the CH region in SgK269/SgK223 association. Importantly, although SgK269 bridged SgK223 to Grb2, it was unable to activate Stat3 or efficiently enhance migration in SgK223 knock-out cells generated by CRISPR/Cas9.

  3. Findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity.

  4. report is the first to provide evidence that PEAK1 mediates signaling cross talk between TGFbeta receptors and integrin/Src/MAPK pathways and that PEAK1 is an important molecular regulator of TGFbeta-induced tumor progression and metastasis in breast cancer

  5. this regard, we have demonstrated that PEAK1 is necessary for TGFbeta to induce ZEB1-mediated EMT in the context of fibronectin/ITGB3 activation.

  6. Suggest that loss of PEAK1/E-cadherin may play an important role in carcinogenesis and development of gastric cancer through activating epithelial to mesenchymal transition.

  7. eIF5A proteins utilize PEAK1 as a downstream effector to drive pancreatic ductal adenocarcinoma (PDAC) pathogenesis.

  8. results define a novel signaling pathway in basal breast cancer involving Lyn and SgK269 that offers clinical opportunities for therapeutic intervention

  9. phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover

  10. Here, we report that the novel tyrosine kinase PEAK1 is upregulated in human malignancies, including human PDACs and pancreatic intraepithelial neoplasia (PanIN).

  11. Also known as SgK269. Contains a divergent and possibly inactive eukaryotic protein kinase domain. Has one human paralog, known as SgK223 or pragmin. These two constitute the NKF3 subfamily of protein kinases, found in vertebrates and echinoderms

PEAK1 Protein Überblick

Protein Überblick

Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN (By similarity).

Genbezeichner und Symbole assoziert mit PEAK1

  • pseudopodium enriched atypical kinase 1 (PEAK1)
  • pseudopodium-enriched atypical kinase 1 (Peak1)
  • 1110049L02Rik Protein
  • 9530046P14 Protein
  • AA690169 Protein
  • BE132841 Protein
  • mKIAA2002 Protein
  • Peak1 Protein
  • SGK269 Protein

Bezeichner auf Proteinebene für PEAK1

pseudopodium enriched atypical kinase , pseudopodium-enriched atypical kinase 1 , sugen kinase 269 , tyrosine-protein kinase SgK269 , NKF3 kinase family member

79834 Homo sapiens
244895 Mus musculus
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