Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
PROS1 encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. Zusätzlich bieten wir Ihnen PROS1 Antikörper (102) und PROS1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
Showing 7 out of 24 products:
these results suggest a novel pathogenic role of SPE B that initiates protein S degradation followed by the inhibition of apoptotic cell clearance by macrophages
Developed functional protein S assays that measure both the activated protein C (zeige PROC ELISA Kits)- and TFPI (zeige TFPI ELISA Kits)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.
Taken together, our gain-of-function, loss-of-function analyses suggest that PROS may facilitate cell proliferation and promote castration resistance in human castration-resistant PCa-like cells via its apoptosis-regulating property.
we identify PROS1 as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL (zeige AXL ELISA Kits) expression
The prevalence of PS de fi ciency in the present study was higher than in Western countries and con (zeige DISP1 ELISA Kits) fi rms the high prevalence of PS de fi ciency in Asian populations
Patients with type 2 diabetes had significantly lower circulating free protein S than healthy control subjects
In the present study, gene analysis of six unrelated Japanese families diagnosed with congenital protein S deficiency identified five missense mutations in the PROS1 gene - c.757C>T (Ala139Val; A139V), c.1346 G>T (Cys449Phe; C449F), c.1352G>A (Arg451Gln; R451Q), c.1424G>T (Cys475Phe; C475F) and c.1574C>T (Ala525Val; A525V) - and one frameshift mutation, c.2135delA (Asp599ThrfsTer13; D599TfsTer13).
The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROS1 is 56.4 (95% CI, 5.3-351.1; P = 0.001).
described a novel PROS1 frameshift mutation, c.74dupA, in a hereditary protein S deficiency family. Interestingly, both of the proband and his mother carried the mutation and had a protein S deficiency, however, only the proband suffered a pulmonary embolism while his mother had no history of any thrombosis, suggesting that a triggering event might have been involved in the thrombus formation.
PROS1 may play an important role in the development of glioblastoma multiforme through cellular proliferation, migration and invasion as well as apoptosis.
Activated protein C (zeige PROC ELISA Kits)(APC (zeige APC ELISA Kits)) combined with protein S(PS) had significant antithrombotic effect. APC (zeige APC ELISA Kits) combined with PS prolonged clotting time. Dependence on APC (zeige APC ELISA Kits)-cofactor activity of PS for expression of anticoagulant activity by APC (zeige APC ELISA Kits).
This study identifies a duple role for PROS1 in stem-cell quiescence and as a pro-neurogenic factor, and highlights a unique segregation of increased stem cell proliferation from enhanced neuronal differentiation.
Mice overexpressing protein S showed significant improvements in blood glucose level, glucose tolerance, insulin (zeige INS ELISA Kits) sensitivity, and insulin (zeige INS ELISA Kits) secretion compared with wild-type counterparts. diabetic protein S transgenic mice developed significantly less severe diabetic glomerulosclerosis than controls.
By revealing that neural stem-like cells act within the SVZ neurogenic niche as phagocytes and that the ProS/MerTK (zeige MERTK ELISA Kits) path represents an endogenous regulatory mechanism for SVZ cell phagocytic activity
Optimal TAM (zeige CCNA1 ELISA Kits) signaling requires coincident TAM (zeige CCNA1 ELISA Kits) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (zeige CCNA1 ELISA Kits) receptor tyrosine kinases Tyro3 (zeige TYRO3 ELISA Kits), Axl (zeige AXL ELISA Kits), and Mer (zeige ERH ELISA Kits) and their ligands Gas6 (zeige GAS6 ELISA Kits) and Protein S.
Data indicate that activated T cells express Pros1.
Results demonstrate that Protein S is a Mer (zeige ERH ELISA Kits) ligand, and is active in Mer (zeige ERH ELISA Kits)-driven phagocytosis in the retina.
A self-regulatory mechanism of Toll (zeige TLR4 ELISA Kits)-like receptor signalling through the suppression of Gas6 (zeige GAS6 ELISA Kits) and ProS expression is described.
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM (zeige CCNA1 ELISA Kits) receptor Tyro3 (zeige TYRO3 ELISA Kits) and sphingosine 1-phosphate receptor1.
results demonstrate that ProS is a pleiotropic anticoagulant with activated Protein C (zeige PROC ELISA Kits)-independent activities and highlight new roles for ProS in vascular development and homeostasis
Pregnancy causes a decrease in APC (zeige APC ELISA Kits) resistance in mice, which can be explained by the elevation of protein S levels and increased TFPI (zeige TFPI ELISA Kits) activity in plasma.
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.
vitamin K-dependent protein S
, protein Sa
, vitamin K-dependent plasma protein S
, vitamin K-dependent protein S preproprotein