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The protein encoded by PCSK7 belongs to the subtilisin-like proprotein convertase family. Zusätzlich bieten wir Ihnen Proprotein Convertase Subtilisin/kexin Type 7 Antikörper (34) und und viele weitere Produktgruppen zu diesem Protein an.
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Human PCSK7 Protein expressed in Wheat germ - ABIN1314363
Heng, Dynon, Li, Edgell, Walton, Rombauts, Vollenhoven, Nie: Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. in Analytical biochemistry 2015
SPC7 is required for normal development of the eye and brain, possibly through processing BMPs, though other potential substrates cannot be excluded.
PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
Our present data suggest that PCSK7 as well as PCSK9 may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes.
PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis.
Furin and PC7 siRNAs induced HIF-1alpha protein by increasing its translation, resulting in upregulation of VEGF-A.
The data suggest that PCSK7 genotypes may interact with dietary CHO intake on changes in insulin sensitivity in the white Americans.
Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis patients homozygous for HFE C282Y.
overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
Among the PC family members, only furin activates hepcidin in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100
Region encoded by amino acids ala713-asp730 is essential and sufficient for endocytosis.
PCSK7 is involved in sTfR generation and iron homeostasis.
Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.
PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.
Mass spectrometry analysis provides evidence that the HLA-B51-presented peptide profile is altered in the absence of peptide-loading complex quality control or lack of PC7 function in major histocompatibility (MHC) class I-mediated antigen presentation.
we investigated the specificity and potency of complete prodomains and short C-terminal prodomain peptides of each SPC on highly purified, soluble enzyme preparations of human SPC1, SPC6, and SPC7.
in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only
PC7 has a critical role in normal processing of cholecystokinin in mouse brain
PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.
Data show that BDNF and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.
proprotein convertase PC7
, proprotein convertase subtilisin/kexin type 7
, proprotein convertase subtilisin/kexin type 7-like
, lymphoma proprotein convertase
, prohormone convertase 7
, prohormone convertase PC7
, proprotein convertase 7
, proprotein convertase 8
, subtilisin/kexin-like protease PC7
, subtilisin-like proprotein convertase 7