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The protein encoded by PCSK7 belongs to the subtilisin-like proprotein convertase family.
Showing 4 out of 8 products:
Human PCSK7 Protein expressed in Wheat germ - ABIN1314363
Heng, Dynon, Li, Edgell, Walton, Rombauts, Vollenhoven, Nie: Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. in Analytical biochemistry 2015
SPC7 is required for normal development of the eye and brain, possibly through processing BMPs, though other potential substrates cannot be excluded.
PCSK7 is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
Our present data suggest that PCSK7 as well as PCSK9 (zeige PCSK9 Proteine) may be associated with lipids, especially triglyceride, and may serve as a candidate for a new drug target to treat lipid abnormality syndromes.
PCSK7 rs236918 C allele is a risk factor for cirrhosis development in Italian patients with HFE-Hemochromatosis (zeige HFE Proteine).
Furin (zeige FURIN Proteine) and PC7 siRNAs induced HIF-1alpha (zeige HIF1A Proteine) protein by increasing its translation, resulting in upregulation of VEGF-A (zeige VEGFA Proteine).
The data suggest that PCSK7 genotypes may interact with dietary CHO (zeige COL11A1 Proteine) intake on changes in insulin (zeige INS Proteine) sensitivity in the white Americans.
Results demonstrate that PCSK7 variation is a strong host risk factor of liver cirrhosis in hereditary hemochromatosis (zeige HFE Proteine) patients homozygous for HFE (zeige HFE Proteine) C282Y.
overexpression of PCs, furin (zeige FURIN Proteine) and PC5 (zeige PCSK5 Proteine), but not PC7, which are all expressed in SMC (zeige DYM Proteine), increase PKGI (zeige PRKG1 Proteine) cleavage in a dose-dependent manner
Among the PC family members, only furin (zeige FURIN Proteine) activates hepcidin (zeige HAMP Proteine) in hepatocytes, and uniquely the full-length membrane-bound PC7 can directly shed hTfR1 by cleavage at Arg100
PCSK7 is involved in sTfR (zeige TFRC Proteine) generation and iron homeostasis.
Proprotein convertase PC7 enhances the activation of the EGF receptor (zeige EGFR Proteine) pathway through processing of the EGF (zeige EGF Proteine) precursor.
PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking.
PC7 has a critical role in normal processing of cholecystokinin (zeige CCK Proteine) in mouse brain
PC7 and the related proteases Furin (zeige FURIN Proteine) and Pace4 regulate E-cadherin (zeige CDH1 Proteine) function during blastocyst formation.
Data show that BDNF (zeige BDNF Proteine) and PC7 mRNAs are colocalized in hippocampus and amygdala and that mature BDNF (zeige BDNF Proteine) protein levels are reduced in these brain areas in proprotein convertase PC7 knockout mice.
in binding VEGFR-2 (zeige KDR Proteine), furin (zeige FURIN Proteine) and PC5 (zeige PCSK5 Proteine) promote cleavage of N-and C-terminal VEGF-D (zeige Figf Proteine) propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.
proprotein convertase PC7
, proprotein convertase subtilisin/kexin type 7
, proprotein convertase subtilisin/kexin type 7-like
, lymphoma proprotein convertase
, prohormone convertase 7
, prohormone convertase PC7
, proprotein convertase 7
, proprotein convertase 8
, subtilisin/kexin-like protease PC7
, subtilisin-like proprotein convertase 7