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anti-PLEC Antikörper

46 Treffer:

anti-PLEC Antikörper (Plectin) (AA 2644-2671) Primary Antibody

PLEC Reaktivität: Human, Maus, Ratte IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043900
$280.00
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 4 bis 6 Werktagen

anti-PLEC Antikörper (Plectin) (AA 4384-4493) Primary Antibody

PLEC Reaktivität: Human IF, ELISA, WB Wirt: Maus Monoclonal 4C3 unconjugated
Produktnummer ABIN518954
$600.00
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 12 Werktagen

anti-PLEC Antikörper (Plectin) (AA 4384-4493) Primary Antibody

PLEC Reaktivität: Human ELISA, WB Wirt: Maus Monoclonal 4D12 unconjugated
Produktnummer ABIN518953
$600.00
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 12 Werktagen

anti-PLEC Antikörper (Plectin) (AA 4367-684) Primary Antibody

PLEC Reaktivität: Human, Fisch, Xenopus laevis IHC (fro), IF, IHC (p), WB Wirt: Meerschweinchen Polyclonal unconjugated
Pubmed 1
Produktnummer ABIN113466
$462.00
Zzgl. Versandkosten $45.00
0.1 mL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 6 bis 8 Werktagen

anti-PLEC Antikörper (Plectin) (AA 4384-4493) Primary Antibody

PLEC Reaktivität: Human ELISA, WB Wirt: Maus Polyclonal unconjugated
Produktnummer ABIN562270
$465.71
Zzgl. Versandkosten $45.00
50 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 12 Werktagen

anti-PLEC Antikörper (Plectin) Primary Antibody

PLEC Reaktivität: Human, Maus, Ratte ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7003053
$130.90
Zzgl. Versandkosten $45.00
20 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 8 bis 11 Werktagen

anti-PLEC Antikörper (Plectin) (AA 175-400) Primary Antibody

PLEC Reaktivität: Human ICC, IHC, IP, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6997435
$350.00
Zzgl. Versandkosten $45.00
200 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Verfügbar

anti-PLEC Antikörper (Plectin) (AA 240-320) Primary Antibody

PLEC Reaktivität: Human, Maus, Ratte IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6389102
$367.82
Zzgl. Versandkosten $45.00
100 μL (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 13 Werktagen

anti-PLEC Antikörper (Plectin) (C-Term) Primary Antibody

PLEC Reaktivität: Human IHC (fro), IHC (p), WB Wirt: Meerschweinchen Polyclonal unconjugated
Produktnummer ABIN285899
$908.04
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 9 bis 11 Werktagen

anti-PLEC Antikörper (Plectin) Primary Antibody

PLEC Reaktivität: Human, Maus, Ratte IF (p), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN701965
$339.90
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 4 bis 6 Werktagen
  • Typ Primary
    • Primary
  • Target Plectin (PLEC)
    • Plectin (PLEC)
    • Histone 3 (H3)
    • Tumor Protein P53 (TP53)
    • Epidermal Growth Factor Receptor (EGFR)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • CD4
    • tau Protein
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • Tumor Necrosis Factor alpha (TNF alpha)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Interferon gamma (IFNG)
    • Nuclear Factor-kB p65 (NFkBP65)
    • Estrogen Receptor 1 (ESR1)
    • Albumin (ALB)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • CD8a Molecule (CD8A)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • Tuberous Sclerosis 2 (TSC2)
    • CD19 Molecule (CD19)
    • CD3 epsilon (CD3E)
    • Hemagglutinin (HA)
    • Integrin alpha M (ITGAM)
    • CD8
    • Histone H4
    • CD44
    • Jun Proto-Oncogene (JUN)
    • Interleukin 6 (IL6)
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • Myc Proto-Oncogene protein (MYC)
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • Interleukin 2 Receptor, alpha (IL2RA)
    • Catenin, beta (CATNB)
    • CD5
    • Vimentin (VIM)
    • Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1)
    • Mucin 1 (MUC1)
    • CD3
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Glial Fibrillary Acidic Protein (GFAP)
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • CD34
    • Interleukin 2 (IL2)
    • Insulin Receptor Substrate 1 (IRS1)
    • Keratin 18 (KRT18)
    • Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
    • Amyloid beta (A4) Precursor Protein (APP)
    • CD14
    • Tuberous Sclerosis 1 (TSC1)
  • Anwendung
    • Western Blotting (WB)
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    • Immunohistochemistry (IHC)
    • ELISA
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    • Immunofluorescence (IF)
    • Immunohistochemistry (Frozen Sections) (IHC (fro))
    • Flow Cytometry (FACS)
    • Immunocytochemistry (ICC)
    • Immunoprecipitation (IP)
    • Immunofluorescence (fixed cells) (IF/ICC)
  • Reaktivität
    • Human
    • Maus
    • Ratte
    • Xenopus laevis
    • Fisch
    • Rind (Kuh)
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Wirt
    • Kaninchen
    • Meerschweinchen
    • Maus
  • Klonalität
    • Polyclonal
    • Monoclonal
  • Klon
    • 4D12
    • 10F301
    • 4C3
    • 6D75
    • RB56747
  • Bindungsspezifität
    • C-Term
    • AA 1744-1929
    • AA 4367-4684
    • AA 4384-4493
    • AA 175-400
    • AA 240-320
    • AA 2644-2671
    • AA 4241-4275
    • AA 4367-684
    • AA 4384-4494
    • Middle Region
  • Konjugat
    • Unkonjugiert
    • Biotin
    • Alexa Fluor 750
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • FITC
    • HRP
    • Alexa Fluor 350
    • Cy3
    • Cy5
    • Cy5.5
    • Cy7
  • Isotyp
    • IgG
    • IgG2a kappa
    • IgG1
    • Ig Fraction
  • Format
    • Liquid
    • Lyophilized

PLEC Antigen-Profil

Protein Überblick

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human\; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974)\; exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used.

Genbezeichner und Symbole assoziert mit anti-Plectin (PLEC) Antikörper

  • plectin (LOC100481602) Antikörper
  • plectin L homeolog (plec.L) Antikörper
  • plectin (PLEC) Antikörper
  • plectin (Plec) Antikörper
  • plectin (LOC786966) Antikörper
  • AA591047 Antikörper
  • AU042537 Antikörper
  • EBS1 Antikörper
  • EBSO Antikörper
  • HD1 Antikörper
  • IFAP300 Antikörper
  • LGMD2Q Antikörper
  • Pcn Antikörper
  • Plec1 Antikörper
  • PLEC1b Antikörper
  • Plectin-1 Antikörper
  • Pltn Antikörper

Bezeichner auf Proteinebene für anti-Plectin (PLEC) Antikörper

plectin , plectin-1-like , hemidesmosomal protein 1 , plectin 1, intermediate filament binding protein 500kDa , plectin-1 , plectin 1 , plectin-6 , 300 kDa intermediate filament-associated protein

GENE ID SPEZIES
100481602 Ailuropoda melanoleuca
398587 Xenopus laevis
5339 Homo sapiens
18810 Mus musculus
64204 Rattus norvegicus
100682530 Cricetulus griseus
786966 Bos taurus
482083 Canis lupus familiaris

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