Peptidase Inhibitor 3, Skin-Derived Proteine (PI3)

PI3 encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. Zusätzlich bieten wir Ihnen Peptidase Inhibitor 3, Skin-Derived Antikörper (82) und Peptidase Inhibitor 3, Skin-Derived Kits (41) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PI3 5266 P19957
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
Human Cells Human His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
HOST_HEK-293T Cells Human His-DYKDDDDK-Strep II Tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
Baculovirus infected Insect Cells Human His tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Human Cells Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage

PI3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , ,
, , ,
Wild boar (Sus scrofa)

Weitere Proteine zu Peptidase Inhibitor 3, Skin-Derived (PI3) Interaktionspartnern

Human Peptidase Inhibitor 3, Skin-Derived (PI3) Interaktionspartner

  1. Elafin decreased in active patients with inflammatory bowel disease and was negatively correlated with disease activity, suggesting that elafin may play a protective role

  2. Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome

  3. UV phototoxicity-induced pre-elafin inside keratinocytes prior to cornified envelope formation could be involved in UV-induced keratinocyte apoptosis via cystatin-A downregulation resulting in pro-caspase-3 activation.

  4. Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia

  5. significantly higher expression in preterm prelabor ruptured fetal membranes than in membranes from term birth

  6. Our study revealed that high elafin levels identified in smoking- and asthma-related microarray data sets and an epidemiologic study significantly reduced the risk of asthma.

  7. The expression of elafin in fallopian tubes of ectopic pregnancies is reduced.

  8. The elevations in cervical elafin and SLPI expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor.

  9. PI3 expression was downregulated in 24% of DCIS and 83% of invasive breast tumors. PI3 was also downregulated in 33% of ovarian cystadenomas, 43% of borderline ovarian tumors, and 86% of invasive ovarian carcinomas.

  10. The imbalance between neutrophil elastase and its inhibitors, such as elafin, presents an important therapeutic target in breast cancer.

  11. Higher urinary elafin levels are associated with an increased risk of micro- and macroalbuminuria, acute kidney injury and chronic kidney disease, and death after hematopoietic stem cell transplantation.

  12. cutaneous elafin does not seem to discriminate acute graft-versus-host disease from drug hypersensitivity rash lesions, but there may be an association between cutaneous elafin expression and poor prognosis for patients with cutaneous GVHD

  13. Data indicate that elafin overexpression is associated with poor overall survival.

  14. Low expression of elafin gene correlated with significantly reduced time to relapse, and when combined with high expression of elastase gene was associated with decreased survival in breast cancer patients

  15. Elafin has important roles in normal homoeostasis and at sites of inflammation. These roles include antiprotease and antimicrobial activity.

  16. Results confirm the association between SNP rs2664581 and enhanced risk of developing acute respiratory distress syndrome.

  17. Tubal epithelium from women with hydrosalpinx has lower levels of elafin expression.

  18. Elafin expression in the small intestinal epithelium was lower in patients with active celiac disease compared with control patients. In vitro, elafin significantly slowed the kinetics of the deamidation of the 33-mer peptide to its more immunogenic form.

  19. Production of HBD2 and elafin by vaginal epithelial cells is sensitive to E, suggesting that innate immune protection varies in the vagina across the menstrual cycle.

  20. Elafin expression may establish the diagnosis of pre-engraftment syndrome and graft versus host disease.

Peptidase Inhibitor 3, Skin-Derived (PI3) Protein Überblick

Protein Überblick

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.

Genbezeichner und Symbole assoziert mit PI3

  • peptidase inhibitor 3 (PI3)
  • peptidase inhibitor 3, skin-derived (SKALP) (PI3)
  • cementoin Protein
  • elafin Protein
  • ESI Protein
  • SKALP Protein
  • TRAPPIN-2 Protein
  • WAP3 Protein
  • WFDC14 Protein

Bezeichner auf Proteinebene für PI3

PI-3 , WAP four-disulfide core domain 14 , WAP four-disulfide core domain protein 14 , elafin , elastase-specific inhibitor , pre-elafin , protease inhibitor 3, skin-derived (SKALP) , protease inhibitor WAP3 , skin-derived antileukoproteinase , trappin-2 , elafin preproprotein , peptidase inhibitor 3, skin-derived (SKALP) , TRAPPIN-2 protein , trappin ovine homolog , peptidase inhibitor 3, skin-derived , trappin 8

5266 Homo sapiens
458276 Pan troglodytes
477241 Canis lupus familiaris
574237 Macaca mulatta
641305 Ovis aries
100137037 Pongo abelii
100137495 Papio anubis
783871 Bos taurus
396757 Sus scrofa
102172734 Capra hircus
101752219 Gallus gallus
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