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This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift.
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Results demonstrated that an increased expression of PEG10 is associated vessel invasion, and the overall survival time of PC patients. E2F-1 (zeige E2F1 Proteine) mediated PEG10 overexpression promotes pancreatic cancer (PC) cell proliferation via accelerating cell cycle progression and increase migration and invasion through ERK (zeige EPHB2 Proteine)/MMP7 (zeige MMP7 Proteine) pathway. These results suggest that PEG10 may serve as an oncogene (zeige RAB1A Proteine) in PC pathogenesis.
miR (zeige MLXIP Proteine)-122 suppresses PEG10 expression via direct binding to the 3'-UTR of the PEG10 transcript.
PEG10 expression associates with the lymph node metastasis and overall survival of hepatocellular carcinoma patients.PEG10 expression level is essential for TGF-beta1 (zeige TGFB1 Proteine) induced epithelialmesenchymal transition.
Knockdown of PEG10 expression by siRNA could lead to growth arrest and cell apoptosis in diffuse large B cell lymphoma cells in vitro.
PEG10 protein could be a potential biomarker predicting early recurrence and recurrence-free survival in HCC (zeige FAM126A Proteine) patients after curative resection, even in those with normal serum alpha-fetoprotein (zeige AFP Proteine) levels.
Study shows that expression level of PEG10 was significantly elevated in breast cancer tissues and associated with distant metastasis and poor clinical outcome and provides evidence that PEG10 is a crucial oncogene (zeige RAB1A Proteine).
important role in trophoblast proliferation and promotes trophoblast invasion through TIMP-1 (zeige TIMP1 Proteine)
Results revealed that PEG10 high expression was closely associated with the TNM (zeige ODZ1 Proteine) classification in lung cancer and is a critical indicator for poor prognosis. Also, It promotes significantly proliferation, migration and invasion of A549 lung cancer cells.
The downregulated expression of the imprinted gene PEG10 may be an important reason for the occurrence of preeclampsia.
elevated expression of PEG10 is likely to be involved in the pathophysiology of preeclampsia
Loss of DNA methylation (zeige HELLS Proteine) at the Peg10 imprinted gDMD associated with decreased embryonic viability and decreased labyrinthine volume.
Knockdown of Syncytin-A (zeige ERVW-1 Proteine) demonstrated a functional regulation of cell-cell fusion, where knockdown of Peg10 showed no involvement in cell fusion
Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes.
Peg10 gene is imprinted, with preferential expression from the paternal allele, and its deletion results in early embryonic lethality.
Results indicate that the induction of the imprinted gene paternally expressed 10 (PEG10) may play an important role during liver regeneration or carcinogenesis of the hepatocyte.
These findings strongly indicate that peg10 plays a crucial role at the immediate early (zeige JUN Proteine) stage of adipocyte differentiation.
the ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals
the abnormal DNA methylation (zeige HELLS Proteine) epigenetic reprogramming of imprinting PEG10 gene in placenta may be one of the main causes of the abnormal development and death of the transgenic cloned cattle.
polymorphisms in PEG10 and PPP1R9A were associated with fat deposition and carcass traits
The imprinting status of PEG10 is conserved in swine as paternal expression was demonstrated by quantitative allelic sequencing of reciprocal crosses in fetal tissues of whole brain, carcass, liver and placentae.
The expression patterns of PLAGL1 (zeige PLAGL1 Proteine) and PEG10 genes in two breeds of swine are reported.
This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.
MEF3 like 1
, MEF3-like protein 1
, embryonal carcinoma differentiation regulated
, embryonal carcinoma differentiation-regulated protein
, mammalian retrotransposon-derived protein 2
, myelin expression factor 3-like protein 1
, paternally expressed gene 10 protein
, retrotransposon gag domain containing 3
, retrotransposon gag domain-containing protein 3
, retrotransposon-derived gag-like polyprotein
, retrotransposon-derived protein PEG10
, ty3/Gypsy-like protein
, MyEF-3 like
, embryonal carcinoma differentiation regulated protein
, myelin expression factor 3
, paternally expressed 10
, LOW QUALITY PROTEIN: retrotransposon-derived protein PEG10
, retrotransposon-derived protein PEG10-like