Paternally Expressed 10 Proteine (PEG10)

This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. Zusätzlich bieten wir Ihnen Paternally Expressed 10 Antikörper (113) und Paternally Expressed 10 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PEG10 23089 Q86TG7
PEG10 170676 Q7TN75
Ratte PEG10 PEG10 102553587  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage

PEG10 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Paternally Expressed 10 (PEG10) Interaktionspartnern

Human Paternally Expressed 10 (PEG10) Interaktionspartner

  1. PEG10 expression is associated with advanced clinicopathological characteristics and can be used as a prognostic biomarker in patients with solid tumors.

  2. Results demonstrated that an increased expression of PEG10 is associated vessel invasion, and the overall survival time of PC patients. E2F-1 mediated PEG10 overexpression promotes pancreatic cancer (PC) cell proliferation via accelerating cell cycle progression and increase migration and invasion through ERK/MMP7 pathway. These results suggest that PEG10 may serve as an oncogene in PC pathogenesis.

  3. miR-122 suppresses PEG10 expression via direct binding to the 3'-UTR of the PEG10 transcript.

  4. PEG10 expression associates with the lymph node metastasis and overall survival of hepatocellular carcinoma patients.PEG10 expression level is essential for TGF-beta1 induced epithelialmesenchymal transition.

  5. Knockdown of PEG10 expression by siRNA could lead to growth arrest and cell apoptosis in diffuse large B cell lymphoma cells in vitro.

  6. PEG10 protein could be a potential biomarker predicting early recurrence and recurrence-free survival in HCC patients after curative resection, even in those with normal serum alpha-fetoprotein levels.

  7. Study shows that expression level of PEG10 was significantly elevated in breast cancer tissues and associated with distant metastasis and poor clinical outcome and provides evidence that PEG10 is a crucial oncogene.

  8. important role in trophoblast proliferation and promotes trophoblast invasion through TIMP-1

  9. Results revealed that PEG10 high expression was closely associated with the TNM classification in lung cancer and is a critical indicator for poor prognosis. Also, It promotes significantly proliferation, migration and invasion of A549 lung cancer cells.

  10. The downregulated expression of the imprinted gene PEG10 may be an important reason for the occurrence of preeclampsia.

  11. elevated expression of PEG10 is likely to be involved in the pathophysiology of preeclampsia

  12. promotes migration of Burkitt's lymphoma cells via upregulation of matrix metalloproteinase-2 and -9

  13. Overexpression of PEG10 and TSG101 was detected in gallbladder adenocarcinoma.

  14. PEG10 imprinting is lost in a majority of hepatocellular carcinomas and no correlation exists between the imprinting status of PEG10 and its expression in HCC tissues.

  15. the mRNA expression level of PEG10 were significantly up-regulated in tumorous liver tissues compared with corresponding nontumorous counterparts.

  16. In third trimester PEG10 was downregulated in fetal samples group

  17. PEG10 gene is imprinted, with preferential expression from the paternal allele.

  18. miR-122 may be involved in regulation of PEG10 expression hepatoma cell lines.

  19. Evidence for translation initiation from an in-frame, upstream non-AUG (CUG) codon, and from the downstream AUG, resulting in different isoforms.

Mouse (Murine) Paternally Expressed 10 (PEG10) Interaktionspartner

  1. Loss of DNA methylation at the Peg10 imprinted gDMD associated with decreased embryonic viability and decreased labyrinthine volume.

  2. Knockdown of Syncytin-A demonstrated a functional regulation of cell-cell fusion, where knockdown of Peg10 showed no involvement in cell fusion

  3. Programmed -1 ribosomal frameshifting in mouse and human Peg10 genes.

  4. It is a retrotransposon-derived imprinted gene and plays a essential role in placental formation.(review)

  5. Peg10 gene is imprinted, with preferential expression from the paternal allele, and its deletion results in early embryonic lethality.

  6. Results indicate that the induction of the imprinted gene paternally expressed 10 (PEG10) may play an important role during liver regeneration or carcinogenesis of the hepatocyte.

  7. These findings strongly indicate that peg10 plays a crucial role at the immediate early stage of adipocyte differentiation.

  8. the ORF1-2 protein of PEG10, synthesized utilizing the most efficient -1 frameshift mechanism yet documented in vivo, will have an essential function that is intrinsic to the importance of PEG10 in mammals

Cow (Bovine) Paternally Expressed 10 (PEG10) Interaktionspartner

  1. the abnormal DNA methylation epigenetic reprogramming of imprinting PEG10 gene in placenta may be one of the main causes of the abnormal development and death of the transgenic cloned cattle.

Pig (Porcine) Paternally Expressed 10 (PEG10) Interaktionspartner

  1. polymorphisms in PEG10 and PPP1R9A were associated with fat deposition and carcass traits

  2. A transition SNP was identified by microarray expression profiling and confirmed by pyrosequencing in Meishan and white composite swine breeds.

  3. The imprinting status of PEG10 is conserved in swine as paternal expression was demonstrated by quantitative allelic sequencing of reciprocal crosses in fetal tissues of whole brain, carcass, liver and placentae.

  4. The expression patterns of PLAGL1 and PEG10 genes in two breeds of swine are reported.

  5. Gene is monoallelically expressed and may be imprinted in porcine placentas on days 75 and 90 of gestation.

Paternally Expressed 10 (PEG10) Protein Überblick

Protein Überblick

This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.

Genbezeichner und Symbole assoziert mit PEG10

  • paternally expressed 10 (PEG10)
  • paternally expressed 10 (Peg10)
  • AA407948 Protein
  • Edr Protein
  • HB-1 Protein
  • Mar2 Protein
  • Mart2 Protein
  • MEF3L Protein
  • MyEF-3 Protein
  • RGAG3 Protein

Bezeichner auf Proteinebene für PEG10

MEF3 like 1 , MEF3-like protein 1 , embryonal carcinoma differentiation regulated , embryonal carcinoma differentiation-regulated protein , mammalian retrotransposon-derived protein 2 , myelin expression factor 3-like protein 1 , paternally expressed gene 10 protein , retrotransposon gag domain containing 3 , retrotransposon gag domain-containing protein 3 , retrotransposon-derived gag-like polyprotein , retrotransposon-derived protein PEG10 , ty3/Gypsy-like protein , MyEF-3 like , embryonal carcinoma differentiation regulated protein , myelin expression factor 3 , paternally expressed 10 , LOW QUALITY PROTEIN: retrotransposon-derived protein PEG10 , retrotransposon-derived protein PEG10-like

23089 Homo sapiens
170676 Mus musculus
472446 Pan troglodytes
482307 Canis lupus familiaris
618138 Bos taurus
654416 Sus scrofa
700853 Macaca mulatta
100062501 Equus caballus
100359412 Ovis aries
102553587 Rattus norvegicus
100352080 Oryctolagus cuniculus
100720271 Cavia porcellus
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