anti-Paraoxonase 2 (PON2) Antikörper

PON2 encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. Zusätzlich bieten wir Ihnen PON2 Kits (29) und PON2 Proteine (17) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PON2 5445 Q15165
PON2 330260 Q62086
PON2 296851 Q6AXM8
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Top anti-PON2 Antikörper auf antikoerper-online.de

Showing 10 out of 129 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Observed bind size: 39KD 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Ziege Unkonjugiert ELISA, IHC, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details
Human Ziege Unkonjugiert IHC, ELISA   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Human Kaninchen Unkonjugiert EIA, FACS, IHC (p), WB Flow cytometric analysis of K562 cells using PON2 Antibody (N-term) Cat.-No AP53391PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with PON2 Antibody (N-term) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. This data demonstrates the use of PON2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Ziege Unkonjugiert ELISA, IHC, IHC (p), WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB WB Image Sample (50 ug of whole cell lysate) A: mouse liver 10% SDS PAGE antibody diluted at 1:1000 WB Image Sample (30 ug of whole cell lysate) A: A431 , 10% SDS PAGE PON2 antibody antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: PON2 Antibody [NBP1-86365] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY400116) Immunohistochemistry-Paraffin: PON2 Antibody [NBP1-86365] - Immunohistochemical staining of human cerebral cortex shows strong positivity in a subset of glial cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB PON2 Antibody (Center) (ABIN651946) western blot analysis in HepG2 cell line lysates (15 µg/lane). This demonstrates the PON2 antibody detected PON2 protein (arrow). PON2 Antibody (Center) (ABIN651946) western blot analysis in mouse heart tissue lysates (15 µg/lane). This demonstrates the PON2 antibody detected PON2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB PON2 Antibody (N-term)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PON2 antibody detected the PON2 protein (arrow). PON2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PON2 Antibody (N-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details

Am meisten referenzierte anti-PON2 Antikörper

  1. Human Monoclonal PON2 Primary Antibody für IP, WB - ABIN534444 : Reddy, Wadleigh, Grijalva, Ng, Hama, Gangopadhyay, Shih, Lusis, Navab, Fogelman: Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. in Arteriosclerosis, thrombosis, and vascular biology 2001 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal PON2 Primary Antibody für WB - ABIN1573944 : Devarajan, Bourquard, Hama, Navab, Grijalva, Morvardi, Clarke, Vergnes, Reue, Teiber, Reddy: Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. in Antioxidants & redox signaling 2011 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal PON2 Primary Antibody für ELISA, WB - ABIN4346831 : Shin: Paraoxonase gene polymorphism in south-western Korean population. in Journal of Korean medical science 2009 (PubMed)

Weitere Antikörper gegen PON2 Interaktionspartner

Human Paraoxonase 2 (PON2) Interaktionspartner

  1. In donor retina from patients with diabetes, all three PON1, PON2 and PON3 were expressed, and there was a significant increase in PON3 expression compared to control. This might be the reason for the increased thiolactonase activity observed in diabetic retina compared to control

  2. The decrease in monocyte/macrophage PON2 enzymatic activity observed in type 2 diabetes cannot be totally explained by abdominal obesity and insulin resistance.

  3. these results showed that PON2 could represent a molecular biomarker for bladder cancer and suggest a potential role of the enzyme as a prognostic factor for this neoplasm

  4. Study observed a genetic effect in ischemic stroke patients of the north area of the Gran Canaria island linked to the rs7493 variant in the PON2 gene with worse atherogenic ultrasonographic profile in ischemic stroke patients. Conversely, the Cys311Cys homozygosity, which is usually associated with an increased risk of stroke in the general population, was also related to a better ultrasonographic profile.

  5. Paraoxonase 2 (PON2) possesses antiatherogenic properties and is associated with lower Reactive Oxygen Species levels. PON2 is involved in the antioxidative and anti-inflammatory response in intestinal epithelial cells.

  6. PON2 is a new potential biomarker for therapy resistance or a prognostic tumor marker.

  7. PON-2 regulates ENaC activity by modulating its intracellular trafficking and surface expression

  8. Paraoxonase 2 facilitates pancreatic ductal cancer growth and metastasis by stimulating GLUT1-mediated glucose transport.

  9. Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS) production and induces Bim protein production that inhibits cancer progression via the PON2-Bim cascade.

  10. Data suggest that paraoxonases (PON1, PON2, PON3) play roles in innate immunity, inflammatory response, and protection against oxidative stress; these factors are associated with the body's response to infectious diseases; low serum PON1 activities are associated with poor survival in patients with severe sepsis. [REVIEW]

  11. Data show that the mRNA levels of both paraoxonases PON2 and PON3 were significantly upregulated whereas PON1's mRNA was absent in transgenic mouse hearts.

  12. High soluble expression levels were achieved with a yield of 76 mg of fully human PON2 variants per liter of culture media

  13. The PON2 Ser311Cys polymorphism is associated with coronary heart disease risk in Caucasians.

  14. Thi study found that the CC genotype of the PON2 S311C polymorphism is a risk factor for ischemic stroke.

  15. Studies indicate that three paraoxonases PON1, PON2, and PON3 genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties.

  16. PON2 SNPs rs12026 and rs7493 were associated with intracerebral hemorrhage. The C alleles of rs12026 and rs7493 contributed to a decreased risk of ICH.

  17. Data indicate the relationship between ubiqutination of lysine (Lys) 168 and paraoxonase 2 (PON2) catalytic activity.

  18. Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1, PON2, PON3) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL level in blood. [REVIEW]

  19. Haplotype containing two risk alleles of PON1 and PON2 genes was significantly associated with disease diabetes mellitus, type 2.

  20. D1-like receptors inhibit ROS production by altering PON2 distribution in membrane microdomains in the short-term, and by increasing PON2 expression in the long-term.

Mouse (Murine) Paraoxonase 2 (PON2) Interaktionspartner

  1. PON-2 regulates ENaC activity by modulating its intracellular trafficking and surface expression

  2. PON2 plays an important role in innate immune defense against Pseudomonas aeruginosa infection.

  3. macrophage triglyceride accumulation upregulates PON2 expression via MEK/ JNK/c-Jun pathway, and these effects could be related, at least in part, to cellular triglycerides-induced ROS formation.

  4. These results suggest that PON2 is a novel major intracellular factor that protects CNS cells against oxidative stress and confers gender-dependent susceptibility to such stress

  5. Macrophage PON2 modulates mechanisms that link endoplasmic reticulum stress, mitochondrial dysfunction and the development of atherosclerosis.

  6. expression in brain regions and protection against oxidative-stress-mediated neurotoxicity

  7. results demonstrate that PON2 plays an important role in hepatic insulin signalling and underscores the influence of macrophage-mediated inflammatory response on hepatic insulin sensitivity.

  8. Results illustrate that the antiatherogenic effects of PON2 are, in part, mediated by the role of PON2 in mitochondrial function.

  9. Under normal conditions macrophage endoplasmic reticulum stabilizes PON2 activity, and this effect could be attributed to ER proteins and redox status.

  10. PON2 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.

  11. Pomegranite juice consumption antioxidative properties on mouse macrophages are mediated via PJ-induced stimulation of macrophage PON2 expression.

  12. analysis of macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice

  13. PON2 decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity

  14. Increased macrophage PON2 expression under oxidative stress could represent a selective cellular response to reduce oxidative burden, which may lead to attenuation of macrophage foam cell formation.

  15. PON2 stimulation may represent a compensatory mechanism against the increase in cellular superoxide anion production and atherogenesis

  16. biphasic effect of oxidative stress on macrophage PON2 activity could be related to PON2 inactivation (decreased enzymatic activity) under oxidative stress induction at its low range

  17. role in airway epithelial cell inactivation of N-3-oxododecanoyl homoserine lactone; findings show that that Pseudomonas aeruginosa quorum sensing was enhanced in PON2-deficient airway epithelia

  18. macrophages from diabetic mice demonstrate increased oxidative stress and up-regulation of cellular PON2

  19. Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism.

  20. The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.

Pig (Porcine) Paraoxonase 2 (PON2) Interaktionspartner

  1. The expression of the PON2 gene was greater in Meishan pig than that in Yorkshire on gestational day 26 and 90.

Cow (Bovine) Paraoxonase 2 (PON2) Interaktionspartner

  1. The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1, 2 and 3 in granulosa cells and PON1 activity in follicular fluid and plasma of dairy cows.

PON2 Antigen-Profil

Protein Überblick

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Genbezeichner und Symbole assoziert mit anti-Paraoxonase 2 (PON2) Antikörper

  • serum paraoxonase/arylesterase 2 (LOC100303695) Antikörper
  • paraoxonase 2 (PON2) Antikörper
  • paraoxonase 2 L homeolog (pon2.L) Antikörper
  • serum paraoxonase/arylesterase 2 (BDBG_00600) Antikörper
  • Serum paraoxonase/arylesterase 2 (pon2) Antikörper
  • paraoxonase 2 (Pon2) Antikörper
  • 6330405I24Rik Antikörper
  • AI481612 Antikörper
  • MGC53915 Antikörper
  • pon1 Antikörper
  • pon2 Antikörper

Bezeichner auf Proteinebene für anti-Paraoxonase 2 (PON2) Antikörper

A-esterase 2 , Aromatic esterase 2 , PON 2 , Serum aryldialkylphosphatase 2 , Serum paraoxonase/arylesterase 2 , paraoxonase 2 , celiac disease 2 , serum paraoxonase/arylesterase 2-like , serum paraoxonase/arylesterase 2 , aromatic esterase 2 , paraoxonase nirs , serum aryldialkylphosphatase 2

GENE ID SPEZIES
100303695 Meleagris gallopavo
463549 Pan troglodytes
100145861 Ovis aries
100218152 Taeniopygia guttata
100340152 Oryctolagus cuniculus
100407939 Callithrix jacchus
380341 Xenopus laevis
8507698 Ajellomyces dermatitidis SLH14081
100196477 Salmo salar
5445 Homo sapiens
330260 Mus musculus
296851 Rattus norvegicus
403855 Canis lupus familiaris
100142663 Sus scrofa
281417 Bos taurus
395830 Gallus gallus
Ausgewählte Anbieter für anti-PON2 (PON2) Antikörper
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