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PON2 encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. Zusätzlich bieten wir Ihnen PON2 Kits (29) und PON2 Proteine (17) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Polyclonal PON2 Primary Antibody für WB - ABIN1573944
Devarajan, Bourquard, Hama, Navab, Grijalva, Morvardi, Clarke, Vergnes, Reue, Teiber, Reddy: Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. in Antioxidants & redox signaling 2011
Show all 2 Pubmed References
Human Polyclonal PON2 Primary Antibody für ELISA, WB - ABIN4346831
Shin: Paraoxonase gene polymorphism in south-western Korean population. in Journal of Korean medical science 2009
In donor retina from patients with diabetes, all three PON1 (zeige PON1 Antikörper), PON2 and PON3 (zeige PON3 Antikörper) were expressed, and there was a significant increase in PON3 (zeige PON3 Antikörper) expression compared to control. This might be the reason for the increased thiolactonase activity observed in diabetic retina compared to control
The decrease in monocyte/macrophage PON2 enzymatic activity observed in type 2 diabetes cannot be totally explained by abdominal obesity and insulin (zeige INS Antikörper) resistance.
these results showed that PON2 could represent a molecular biomarker for bladder cancer and suggest a potential role of the enzyme as a prognostic factor for this neoplasm
Study observed a genetic effect in ischemic stroke patients of the north area of the Gran (zeige GCA Antikörper) Canaria island linked to the rs7493 variant in the PON2 gene with worse atherogenic ultrasonographic profile in ischemic stroke patients. Conversely, the Cys311Cys homozygosity, which is usually associated with an increased risk of stroke in the general population, was also related to a better ultrasonographic profile.
Paraoxonase 2 (PON2) possesses antiatherogenic properties and is associated with lower Reactive Oxygen Species levels. PON2 is involved in the antioxidative and anti-inflammatory response in intestinal epithelial cells.
PON2 is a new potential biomarker for therapy resistance or a prognostic tumor marker.
PON-2 regulates ENaC (zeige SCNN1A Antikörper) activity by modulating its intracellular trafficking and surface expression
Paraoxonase 2 facilitates pancreatic ductal cancer growth and metastasis by stimulating GLUT1 (zeige SLC2A1 Antikörper)-mediated glucose transport.
Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS (zeige ROS1 Antikörper)) production and induces Bim (zeige BCL2L11 Antikörper) protein production that inhibits cancer progression via the PON2-Bim (zeige BCL2L11 Antikörper) cascade.
Data suggest that paraoxonases (PON1 (zeige PON1 Antikörper), PON2, PON3 (zeige PON3 Antikörper)) play roles in innate immunity, inflammatory response, and protection against oxidative stress; these factors are associated with the body's response to infectious diseases; low serum PON1 (zeige PON1 Antikörper) activities are associated with poor survival in patients with severe sepsis. [REVIEW]
PON2 plays an important role in innate immune defense against Pseudomonas aeruginosa infection.
macrophage triglyceride accumulation upregulates PON2 expression via MEK (zeige MDK Antikörper)/ JNK/c-Jun pathway, and these effects could be related, at least in part, to cellular triglycerides-induced ROS (zeige ROS1 Antikörper) formation.
These results suggest that PON2 is a novel major intracellular factor that protects CNS cells against oxidative stress and confers gender-dependent susceptibility to such stress
Macrophage PON2 modulates mechanisms that link endoplasmic reticulum stress, mitochondrial dysfunction and the development of atherosclerosis.
results demonstrate that PON2 plays an important role in hepatic insulin (zeige INS Antikörper) signalling and underscores the influence of macrophage-mediated inflammatory response on hepatic insulin (zeige INS Antikörper) sensitivity.
Results illustrate that the antiatherogenic effects of PON2 are, in part, mediated by the role of PON2 in mitochondrial function.
Under normal conditions macrophage endoplasmic reticulum stabilizes PON2 activity, and this effect could be attributed to ER proteins and redox status.
PON2 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.
Pomegranite juice consumption antioxidative properties on mouse macrophages are mediated via PJ-induced stimulation of macrophage PON2 expression.
The expression of the PON2 gene was greater in Meishan pig than that in Yorkshire on gestational day 26 and 90.
The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (zeige PON1 Antikörper), 2 and 3 in granulosa cells and PON1 (zeige PON1 Antikörper) activity in follicular fluid and plasma of dairy cows.
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
, Aromatic esterase 2
, PON 2
, Serum aryldialkylphosphatase 2
, Serum paraoxonase/arylesterase 2
, paraoxonase 2
, celiac disease 2
, serum paraoxonase/arylesterase 2-like
, serum paraoxonase/arylesterase 2
, aromatic esterase 2
, paraoxonase nirs
, serum aryldialkylphosphatase 2