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MTMR8 encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup.
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Here, the crystal structure of the phosphatase domain of MTMR8 is reported.
East African population that gave rise to non-Africans underwent a selective sweep affecting the subcentromeric region where MTMR8 is located
These data indicate that Mtmr8 is essential for vasculature development in zebrafish embryos, and may play a role in arterial specification through repressing PI3K activity.
a conserved functional cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development
This gene encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup. Family members are dual-specificity phosphatases and the encoded protein contains a phosphoinositide-binding domain (PID) and a SET-interacting domain (SID). Defects in other family members have been found in myotubular myopathic diseases.
myotubularin-related protein 8
, myotubularin related protein 9
, myotubularin related protein 8
, myotubularin related protein 8-like
, myotubularin-related protein 8-like
, Myotubularin-related protein 6
, myotubularin-related protein 6