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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1) Antikörper

Histone methyltransferase that plays an essential role in early development and hematopoiesis. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Ratte MLL1 MLL1 315606  
MLL1 214162 P55200
MLL1    
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Top anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 Antikörper auf antikoerper-online.de

Showing 10 out of 10 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert DB Dot blot analysis of Phospho-TJP2-S978 Antibody Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. 400 μL 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert WB   100 μL 2 bis 3 Tage
$280.00
Details
Human Kaninchen Unkonjugiert ELISA   200 μL 11 bis 16 Tage
$594.00
Details
Human Kaninchen FITC ELISA   200 μL 16 Days
$743.29
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Human Kaninchen PE ELISA   200 μL 16 Days
$743.29
Details
Human Kaninchen HRP ELISA   200 μL 16 Days
$743.29
Details
Human Kaninchen APC ELISA   200 μL 16 Days
$743.29
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Human Kaninchen Biotin ELISA   200 μL 16 Days
$743.29
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Human Kaninchen Alkaline Phosphatase (AP) ELISA   200 μL 16 Days
$743.29
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Human Kaninchen Unkonjugiert WB   100 μL 9 bis 11 Tage
$521.29
Details

Weitere Antikörper gegen Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 Interaktionspartner

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1) Interaktionspartner

  1. Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

  2. Provide molecular insights into how SETD2 mutations accelerate MLLr leukemogenesis.

  3. Wild-type MLL1 is a regulator of pre-BCR signaling.

  4. Targeting PRMT5 using small-molecule inhibitors in the treatment of leukemias harboring MLL rearrangements.

  5. Kmt2a is also important in memory formation

  6. Collectively, these data indicated that ATR or ATM inhibition represent potential therapeutic strategies for the treatment of AML, especially MLL-driven leukemias.

  7. Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood.

  8. NUP98-HOXA9 interacts with MLL via the NUP98 second FG repeat domain. In the absence of MLL (in knockout mice), NUP98-HOXA9-induced cell immortalization and leukemogenesis are severely inhibited. MLL is important for the recruitment of NUP98-HOXA9 to the HOXA locus and for NUP98-HOXA9-induced HOXA gene expression. MLL is crucial for NUP98-HOXA9 leukemia initiation.

  9. Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model.

  10. These results define an important role for MLL1 in regulating macrophage-mediated inflammation in wound repair and identify a potential target for the treatment of chronic inflammation in diabetic wounds.

  11. these results implicate an important role for MLL1-dependent epigenetic regulation of macrophage antimicrobial functions

  12. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.

  13. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  14. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  15. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  16. HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development.

  17. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.

  18. Set1 role in cellular reprogramming and its interactions with Dpy30,Myc,Sox2 and Ash2l reprogramming factors

  19. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  20. We have demonstrated that the Mll1 gene is critical to Th1 differentiation in humans and mice

Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1) Antigen-Profil

Protein Überblick

Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).

Genbezeichner und Symbole assoziert mit MLL1

  • lysine methyltransferase 2A (Kmt2a) Antikörper
  • lysine (K)-specific methyltransferase 2A (Kmt2a) Antikörper
  • 6430520K01 Antikörper
  • ALL-1 Antikörper
  • All1 Antikörper
  • Cxxc7 Antikörper
  • HRX Antikörper
  • HTRX1 Antikörper
  • mKIAA4050 Antikörper
  • Mll Antikörper
  • Mll1 Antikörper

Bezeichner auf Proteinebene für MLL1

Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene) , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia 1 , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax Drosophila , zinc finger protein HRX

GENE ID SPEZIES
315606 Rattus norvegicus
214162 Mus musculus
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