anti-Mitofusin 1 (MFN1) Antikörper

The protein encoded by MFN1 is a mediator of mitochondrial fusion. Zusätzlich bieten wir Ihnen Mitofusin 1 Proteine (13) und Mitofusin 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MFN1 55669 Q8IWA4
MFN1 67414 Q811U4
MFN1 192647 Q8R4Z9
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Top anti-Mitofusin 1 Antikörper auf antikoerper-online.de

Showing 10 out of 119 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IHC, WB 100 μg 15 bis 18 Tage
$360.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-MFN1 Antibody Titration: 0.2-1 ug/mlPositive Control: Human Placenta WB Suggested Anti-MFN1  Antibody Titration: 0.2-1 µg/mL  Positive Control: Human Placenta 100 μL 2 bis 3 Tage
$319.00
Details
Human Maus Unkonjugiert RNAi, ELISA, WB MFN1 monoclonal antibody (M04), clone 3C9 Western Blot analysis of MFN1 expression in HeLa Western blot analysis of MFN1 over-expressed 293 cell line, cotransfected with MFN1 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with MFN1 monoclonal antibody (M04), clone 3C9. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert WB Anti- Mitofusin 1 Picoband antibody, Western blotting All lanes: Anti Mitofusin 1  at 0.5ug/ml Lane 1: Rat Cardiac Muscle Tissue Lysate at 50ug Lane 2: Rat Kidney Tissue Lysate at 50ug Lane 3: Mouset Cardiac Muscle Tissue Lysate at 50ug Lane 4: HELA Whole Cell Lysate at 40ug Lane 5: COLO320 Whole Cell Lysate at 40ug Lane 6: A549 Whole Cell Lysate at 40ug Predicted bind size: 84KD Observed bind size: 84KD 100 μg 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert FACS, IF (p), IHC (p), WB Rat brain lysates probed with Anti-Mfn1 Polyclonal Antibody  at 1:5000 90min in 37˚C. RSC96 probed with Mfn1 Polyclonal Antibody, Unconjugated  at 1:100 for 30 minutes followed by incubation with a conjugated secondary (PE Conjugated) (green) for 30 minutes compared to control cells (blue), secondary only (light blue) and isotype control (orange). 100 μL 3 bis 7 Tage
$329.45
Details
Hund Ziege Unkonjugiert IHC, IHC (p) Adrenal, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert EIA, WB MFN1 Antibody (Center) western blot analysis in Jurkat cell line lysates (35µg/lane).This demonstrates the MFN1 antibody detected the MFN1 protein (arrow). 0.4 mL 6 bis 8 Tage
$484.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert IHC, IHC (p), WB 100 μL 11 bis 14 Tage
$522.50
Details
Human Maus Unkonjugiert WB 100 μL 11 bis 14 Tage
$522.50
Details

Am meisten referenzierte anti-Mitofusin 1 Antikörper

  1. Human Monoclonal MFN1 Primary Antibody für RNAi, ELISA - ABIN527615 : Zanna, Ghelli, Porcelli, Karbowski, Youle, Schimpf, Wissinger, Pinti, Cossarizza, Vidoni, Valentino, Rugolo, Carelli: OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. in Brain : a journal of neurology 2008 (PubMed)
    Show all 14 Pubmed References

  2. Mouse (Murine) Monoclonal MFN1 Primary Antibody für ICC, IF - ABIN4334757 : White, Puppa, Sato, Gao, Price, Baynes, Kostek, Matesic, Carson: IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse. in Skeletal muscle 2012 (PubMed)
    Show all 10 Pubmed References

  3. Mammalian Monoclonal MFN1 Primary Antibody für ISt, IHC - ABIN1304823 : Elezaby, Sverdlov, Tu, Soni, Luptak, Qin, Liesa, Shirihai, Rimer, Schaffer, Wilson S, Edward J: Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. in Journal of molecular and cellular cardiology 2015 (PubMed)
    Show all 5 Pubmed References

  4. Human Polyclonal MFN1 Primary Antibody für ICC, IF - ABIN4334755 : Miller, Knaub, Olivera-Fragoso, Keller, Balasubramaniam, Watson, Reusch: Nitric oxide regulates vascular adaptive mitochondrial dynamics. in American journal of physiology. Heart and circulatory physiology 2013 (PubMed)
    Show all 5 Pubmed References

  5. Human Polyclonal MFN1 Primary Antibody für FACS, IF (p) - ABIN670071 : Lou, Guan, Liu, Liu, Zhang, Pan, Pei: The influence of chronic fluorosis on mitochondrial dynamics morphology and distribution in cortical neurons of the rat brain. in Archives of toxicology 2013 (PubMed)
    Show all 3 Pubmed References

  6. Cow (Bovine) Polyclonal MFN1 Primary Antibody für WB - ABIN2787347 : Bonala, McFarlane, Ang, Lim, Lee, Chua, Lokireddy, Sreekanth, Leow, Meng, Shyong, Lee, Gluckman, Sharma, Kambadur: Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. in Molecular endocrinology (Baltimore, Md.) 2013 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal MFN1 Primary Antibody für IHC, ELISA - ABIN1088817 : Meng, Liu, Liu, Song, Liu, Xie, Han, Ji: Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3-dependent manner. in British journal of pharmacology 2018 (PubMed)

Weitere Antikörper gegen Mitofusin 1 Interaktionspartner

Cow (Bovine) Mitofusin 1 (MFN1) Interaktionspartner

  1. The results showed that high level of Mfn1 expression significantly improved the embryo development rates by increasing ATP level and Deltapsim, while reducing H(2)O(2) generation.

Human Mitofusin 1 (MFN1) Interaktionspartner

  1. Structural basis for how MFN1 mediates homotypic membrane fusion.

  2. heptad repeat domain of Mitofusin proteins induces membrane fusion and possesses a conserved amphipathic helix that folds upon interaction with the lipid bilayer surface.

  3. The mRNA upregulation of Mitofusin 1 and 2 provides first insight into the complex changes of mitochondrial dynamics in cardiomyocytes of patients with reversible heart failure due to tachycardiomyopathy.

  4. The results lead to a revised understanding of Mfn 1 as single-spanning outer membrane proteins with an Nout-Cin orientation, providing functional insight into the IMS contribution to redox-regulated fusion events.

  5. The results may suggest that TP53BP1 and MFN1 frameshift mutations and their intratumoral heterogeneity (ITH) could contribute to cancer development by inhibiting the TSG activities.

  6. The results show that a metabolic shift from glycolysis in young to mitochondrial respiration in old normal human fibroblasts occurs during chronological lifespan, and MFN1 and OPA1 regulate this process.

  7. mitochondria elongation under hypoxic condition is regulated through SIRT1-mediated MFN1 deacetylation and accumulation.

  8. Regulation of Mfn1 by MGRN1 and the proteasome modulates mitochondrial fusion.

  9. SLC25A46 is a new component in mitochondrial dynamics that serves as a regulator for MFN1/2 oligomerization.

  10. MFN1-positive expression could be seen mainly in ganglion cells after 1 week of minus lens intervention, and with time extension, more and more positive cells appeared in the rod-cone cell and bipolar cell layer, and this phenomenon could not be found in the normal control eyes.

  11. crystal structures of engineered human MFN1 containing the GTPase domain and a helical domain during different stages of GTP hydrolysis; mechanistic model for MFN1-mediated mitochondrial tethering is proposed; results shed light on the molecular basis of mitochondrial fusion and mitofusin-related human neuromuscular disorders

  12. These results suggest that MFN tethers apposing membranes, likely through nucleotide-dependent dimerization.

  13. Improper transcriptional (in)activation of mitofusin-1 and dynamin-related protein 1 during early in vitro embryo development is associated with a decrease in mitochondrial membrane potential and with embryo fragmentation.

  14. A fine balance of Mfn1 levels is maintained by MARCH5-mediated quality control on acetylated Mfn1.

  15. miR-19b targets 3'UTR sequences of Mfn1 genes inhibit the expression of Mfn1

  16. In a amyotrophic lateral sclerosis transgenic mouse model, Mfn1 is significantly increased in spinal cord.

  17. A novel role for the endoplasmic reticulum-associated Gp78 ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy.

  18. Knock-out of mitofusin protein Mfn1 increased the frequency of mitochondrial fission with increased lifetime of unpaired events whereas deletion of both Mfn1 and Mfn2 resulted in an instable dynamics.

  19. These results collectively suggest a role for Mfn1 in regulating the activation of Bax on the outer mitochondrial membrane in a GTPase-dependent manner.

  20. mitochondrial dynamics, particularly those mediated by the mitofusins, play a role in endothelial cell function and viability.

Mouse (Murine) Mitofusin 1 (MFN1) Interaktionspartner

  1. EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter.

  2. data posit MFN1-mediated mitochondrial dynamics in POMC neurons as an intrinsic nutrient-sensing mechanism and unveil an unrecognized link between this subset of neurons and insulin release.

  3. These results highlight the crucial role of MFN1 in maintaining the competency of the STING pathway.

  4. Despite apparent mitochondrial dysfunction, hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction due to impaired mitochondria/sarcoplasmic reticulum tethering.

  5. We found that mouse embryonic fibroblasts lacking Mfn2 have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 does not have a role in adipocyte differentiation.

  6. MFN1 deficiency leads to defects in mitochondrial activity and male infertility.

  7. Report exposes a novel role for Shh in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 and 2.

  8. Ablating Mfn1 eliminates the cardiac-related lethality of Mff knockout mice.

  9. Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1, Mfn2, OPA1 (optic atrophy 1 protein), and Drp1 (dynamin 1-like protein). [REVIEW]

  10. Authors present evidence that metabolically challenged mitochondria undergo active fusion to suppress oxidative stress. In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6.

  11. These findings suggest that mitochondrial impairment is a very early event in Alzheimer disease pathogenesis and abnormal expression of Mfn1 and Mfn2 caused by excessive intracellular Abeta is the possible molecular mechanism.

  12. Data identify MFN1 as an ERK target to modulate mitochondrial shape and apoptosis.

  13. A fine balance of Mfn1 levels is maintained by MARCH5-mediated quality control on acetylated Mfn1.

  14. Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis via Mfn1.

  15. Data unmask an important role for mitochondrial dynamics governed by Mfn1 and Mfn2 in Agrp neurons in central regulation of whole-body energy metabolism.

  16. Our findings establish that Mfn-1 and Mfn-2 are essential in mediating mitochondrial remodeling during postnatal cardiac development, a time of dramatic transitions in the bioenergetics and growth of the heart.

  17. Data suggest that Mfn-1 deletion in cardiomyocytes confers protection against reactive oxygen species-induced mitochondrial dysfunction.

  18. Patterned Purkinje cell degeneration is dependent on caspase activation, leading to the marked decrease of mitofusion 1 in the Harlequin cerebellum.

  19. Double Mfn-null cells show neither outer nor inner membrane fusion, while mitochondria in OPA1-null cells contain multiple matrix compartments bounded together by a single outer membrane, consistent with uncoupling of outer versus inner membrane fusion.

  20. results suggest that the heptad repeat region (HR2) of mfn1 functions as a mitochondrial tether before fusion

Mitofusin 1 (MFN1) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.

Genbezeichner und Symbole assoziert mit anti-Mitofusin 1 (MFN1) Antikörper

  • mitofusin 1b (mfn1b) Antikörper
  • mitofusin 1 (MFN1) Antikörper
  • mitofusin 1 S homeolog (mfn1.S) Antikörper
  • mitofusin 1 (mfn1) Antikörper
  • mitofusin 1 (Mfn1) Antikörper
  • 2310002F04Rik Antikörper
  • 6330416C07Rik Antikörper
  • D3Ertd265e Antikörper
  • Fzo1b Antikörper
  • hfzo1 Antikörper
  • hfzo2 Antikörper
  • HR2 Antikörper
  • MFN1 Antikörper
  • MFN2 Antikörper
  • mitofusin-1 Antikörper
  • mKIAA4032 Antikörper
  • zgc:66150 Antikörper

Bezeichner auf Proteinebene für anti-Mitofusin 1 (MFN1) Antikörper

mitofusin 1 , mitofusin-1 , mitofusin 2 , mitofusin-1-like , fzo homolog , mitochondrial transmembrane GTPase FZO-2 , mitochondrial transmembrane GTPase Fzo-1 , putative transmembrane GTPase , transmembrane GTPase MFN1 , mitochondrial transmembrane GTPase FZO1B

GENE ID SPEZIES
393620 Danio rerio
424973 Gallus gallus
460861 Pan troglodytes
488086 Canis lupus familiaris
495314 Xenopus laevis
515180 Bos taurus
548943 Xenopus (Silurana) tropicalis
100394906 Callithrix jacchus
100586660 Nomascus leucogenys
55669 Homo sapiens
67414 Mus musculus
192647 Rattus norvegicus
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