anti-Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Antikörper

Orphan receptor. Zusätzlich bieten wir Ihnen LGR5 Proteine (8) und LGR5 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
LGR5 14160 Q9Z1P4
LGR5 299802  
LGR5 8549 O75473
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Top anti-LGR5 Antikörper auf antikoerper-online.de

Showing 10 out of 209 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB LGR5/GPR49 Antibody (Loop2) (ABIN389218) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Western blot analysis of anti-LGR5/GPR49 Antibody (loop2) (ABIN389218) in mouse cerebellum tissue lysates (35 µg/lane).LGR5/GPR49(arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert FACS, IF, IHC (p), WB LGR5/GPR49 Antibody (N-term) (ABIN389215) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the LGR5/GPR49 antibody detected the LGR5/GPR49 protein (arrow)(Kindly offered by Dr. Li). Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (N-term) (ABIN389215), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Maus Unkonjugiert FACS, IF, IP, IHC, WB Anti-LGR5 mouse monoclonal antibody ABIN2454875 immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR5 (RC212845). HEK293T cells were transfected with the empty vector control (Left lane) or Human LGR5 expression plasmid (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LGR5. 0.1 mL Anmelden zum Anzeigen Verfügbar
$482.90
Details
Human Kaninchen Unkonjugiert EIA, FACS, IF, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using LGR5 mAb against human LGR5 (AA: 22-178) recombinant protein. (Expected MW is 43.4 kDa) Dilution: 1/500 - 1/2000 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$577.50
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of anti-LGR5/GPR49 Antibody (Center) (ABIN389219) in K562 cell line lysates (35 µg/lane). LGR5/GPR49(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antibody (Center) (ABIN389219), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Maus Unkonjugiert Agon, CyTOF, FACS, ICC Detection of Lgr5/GPR49 in NS0 Mouse Cell Line Transfected with Human Lgr5/GPR49 and eGFP by Flow Cytometry. NS0 mouse myeloma cell line transfected with human Lgr5/GPR49 and eGFP was stained with and either (A) Mouse Anti-Human Lgr5/GPR49 Monoclonal Antibody. Human Lgr5/GPR49 Antibody Induces Activity. Mouse Anti-Human Lgr5/GPR49 Monoclonal Antibody 100 μg Anmelden zum Anzeigen 8 bis 9 Tage
$250.86
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: HeLa B: HeLa membrane fraction C: HepG2 D: HepG2 membrane fraction E: SK-N-SH 7.5% SDS PAGE antibody diluted at 1:500 IHC-P Image LGR5 antibody [C3], C-term detects LGR5 protein on human intestine by immunohistochemical analysis. Sample: Paraffin-embedded human intestine. LGR5 antibody [C3], C-term , dilution: 1:100. 100 μL Anmelden zum Anzeigen 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-GPR49/LGR5 Polyclonal Antibody, Unconjugated (ABIN737916) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded mouse colon carcinoma labeled with Anti-GPR49/LGR5 Polyclonal Antibody, Unconjugated (ABIN737916) at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$329.45
Details

Am meisten referenzierte anti-LGR5 Antikörper

  1. Human Polyclonal LGR5 Primary Antibody für FACS, IF - ABIN389218 : Barker, van Es, Kuipers, Kujala, van den Born, Cozijnsen, Haegebarth, Korving, Begthel, Peters, Clevers: Identification of stem cells in small intestine and colon by marker gene Lgr5. in Nature 2007 (PubMed)
    Show all 11 Pubmed References

  2. Human Monoclonal LGR5 Primary Antibody für BI, FACS - ABIN2689805 : Barker, Huch, Kujala, van de Wetering, Snippert, van Es, Sato, Stange, Begthel, van den Born, Danenberg, van den Brink, Korving, Abo, Peters, Wright, Poulsom, Clevers: Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. in Cell stem cell 2010 (PubMed)
    Show all 8 Pubmed References

  3. Human Monoclonal LGR5 Primary Antibody für BI, FACS - ABIN2689804 : Carmon, Gong, Lin, Thomas, Liu: R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 7 Pubmed References

  4. Human Monoclonal LGR5 Primary Antibody für FACS, IF - ABIN2724692 : Wu, Xie, Gao, Wang, Guo, Tian, Li, Fan: Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers. in Gene 2013 (PubMed)
    Show all 7 Pubmed References

  5. Human Polyclonal LGR5 Primary Antibody für FACS, IF - ABIN389215 : Kanwar, Yu, Nautiyal, Patel, Majumdar: The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. in Molecular cancer 2010 (PubMed)
    Show all 5 Pubmed References

  6. Human Polyclonal LGR5 Primary Antibody für IHC, IHC (fro) - ABIN440586 : Jung, Saif: Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. in Veterinary journal (London, England : 1997) 2015 (PubMed)
    Show all 4 Pubmed References

  7. Human Polyclonal LGR5 Primary Antibody für ELISA, WB - ABIN543553 : Yamamoto, Sakamoto, Fujii, Tsuiji, Kenetaka, Asaka, Hirohashi: Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. in Hepatology (Baltimore, Md.) 2003 (PubMed)
    Show all 3 Pubmed References

  8. Human Polyclonal LGR5 Primary Antibody für FACS, IHC (p) - ABIN389219 : Walker, Zhang, Odorizzi, Burgess: LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines. in PLoS ONE 2011 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal LGR5 Primary Antibody für Agon, CyTOF - ABIN5012945 : Chiou, Yang, Huang, Tang, Yen, Tsai, Chen, Fadhilah, Lin, Jong: Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells. in Scientific reports 2017 (PubMed)

  10. Human Monoclonal LGR5 Primary Antibody für FACS - ABIN4895691 : Arioka, Ito, Hirata, Semi, Yamada, Seishima: Behavior of leucine-rich repeat-containing G-protein coupled receptor 5-expressing cells in the reprogramming process. in Stem cell research 2017 (PubMed)

Weitere Antikörper gegen LGR5 Interaktionspartner

Mouse (Murine) Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Interaktionspartner

  1. LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.

  2. Results show that Lgr5 is expressed at the neuromuscular junction (NMJ) and is a receptor for Rspo2.

  3. Mex3a defines a reserve-like intestinal stem cell population within the Lgr5+ compartment.

  4. sorted Reg4(+) DCS cells promote organoid formation of single Lgr5(+) colon stem cells. DCS cells can be massively produced from Lgr5(+) colon stem cells in vitro by combined Notch inhibition and Wnt activation

  5. The Lgr5-expressing cells differentiate into hair cells in high yield.

  6. Single-cell transcript profiles reveal multilineage priming in early progenitors derived from Lgr5-expressing intestinal stem cells.

  7. Arrb1 reduced the chemotherapy-induced Lgr5 stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling.

  8. demonstrates that Lgr5 cells give rise to both anterior and posterior taste buds during development, and are capable of regenerating posterior taste buds after injury induced by glossopharyngeal nerve transection

  9. Lgr5(+) chief cells are involved in maintaining the homeostatic stem cell pool. Define Lgr5(+) chief cells as a major cell-of-origin of gastric cancer.

  10. Stem cell plasticity enables hair regeneration following Lgr5(+) cell loss.

  11. role for Lgr5(+) cancer stem cells in primary and metastatic colon cancer

  12. Data show that both the number and relative position of Paneth cells and Lgr5+ cells are important for fission.

  13. RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.

  14. adult stem cell marker leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is expressed in the mice nasal respiratory epithelium.

  15. Employing Lgr5-lacZ transgenic mice and Lgr5 in situ hybridization, authors found colonic epithelial stem cells (CESC) markedly more radioresistant in vivo than small intestinal crypt base columnar stem cells.

  16. Our studies show for the first time that Lgr5 is expressed in the NC cells at embryonic day 9.5 (E9.5) and is maintained during embryonic development and postnataly in the stroma of the ventral tongue, and some areas of the oral mucosa and that Lgr5+ cells participate in the maintenance of the stroma.

  17. Genetic fate-mapping of Alkaline phosphate intestinal(+) cells before or during targeted ablation of Lgr5-expressing stem cells generated numerous long-lived crypt-villus "ribbons," indicative of dedifferentiation of enterocyte precursors into Lgr5(+) stems.

  18. Report targeting LGR5+ tumor stem cells with an antibody-drug conjugate as effective treatment for colon cancer.

  19. The generation of new retinal cells, including retinal neurons and Muller glia from Lgr5-expressed amacrine cells, begins in early adulthood and continues as the animal ages.

  20. Endogenous hyaluronic acid increases Lgr5(+) stem cell proliferation, crypt fission, and intestinal lengthening and that these effects are dependent on signaling through CD44 and TLR4.

Human Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Interaktionspartner

  1. Data conclude that LGR5 expression in CTCs may serve as a marker for CRC metastasis.

  2. LGR5 is a new functional GSC marker and prognostic indicator that can promote EMT by activating the Wnt/beta-catenin pathway and would thus be a novel therapeutic target for glioma.

  3. Data found LGR5 as a potential target of miR-340. LGR5 was highly expressed in breast cancer cells. Relative expression of LGR5 was negatively regulated by miR-340. Knockdown of LGR5 also inhibited cell proliferation and drug resistance to docetaxel with enhanced cell apoptosis of breast cancer cells.

  4. knockdown of CASC15 significantly inhibited the proliferation, migration and invasion of colon cancer cells in vitro and in vivo. Following mechanistic experiments, CASC15 was observed to act as a sponge to suppress microRNA (miR)4310 that targeted LGR5.

  5. LGR5 overexpression was associated with high T stage and LN metastasis status in breast cancer. High LGR5 expression was also associated with reduced relapse-free survival, indicating that LGR5 may represent a promising prognostic marker for breast cancer patients.

  6. LGR5 is a critical effector of DDX1 in colorectal cancer cells.

  7. Logarithmic expansion of LGR5-expressing cells was observed in human colorectal cancer.

  8. Our findings indicated that the Lgr5High/DCLK1High expression pattern may be considered as a signature phenotype for intestinal subtypes of gastric carcinoma.

  9. Findings suggest a tumor suppressor role for miR-216a in gliomas, which inhibits glioma cell proliferation, migration, and invasion by targeting LGR5.

  10. LGR5 promotes cancer stem cell traits and chemoresistance in cervical cancer.

  11. LGR5 expression in the epithelium and stroma was associated with tumor stage, and by integrating functional experiments with LGR5-sorted cell RNA sequencing data from adenoma and normal organoids, there were correlations between LGR5 and CRC-specific genes, including dickkopf WNT signaling pathway inhibitor 4 (DKK4) and SPARC-related modular calcium binding 2 (SMOC2

  12. LGR5 expression is transiently upregulated during the early stage of cardiomyocyte differentiation from hPSCs, and although LGR5 expression is not required for maintaining hPSCs in the undifferentiated state, knockdown of LGR5 leads to decreased expression of key cardiac transcription factors at the early stage with eventual lack of robust beating cardiomyocytes at the late stage.

  13. Lgr5 plays important roles in angiogenesis. Lgr5-specific siRNA could be designed into an effective therapeutic agent to inhibit gastric cancer angiogenesis.

  14. A regulatory mechanism of LGR5 expression in gastric carcinogenesis, with SP1 as an important component of the transcriptional complex and LGR5 activity, which is modulated by its ligands RSPO1 and RSPO2, whose expression is modulated by methylation.

  15. these results demonstrate that Lgr5 activation of Wnt/beta-catenin signaling is a potential mechanism to promote the progression of ESCC and ESCC stem cell renewal, and Lgr5 may be used as a molecular target for the development of treatments for ESCC.

  16. Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer.

  17. This study uncovers a novel cross-talk between LGR5 and TGFbeta signaling in colon cancer and identifies LGR5 as a new modulator of TGFbeta signaling able to suppress colon cancer metastasis.

  18. Data show that IKKalpha directly bind to the promoters of LGR5, in turn, upregulating LGR5 expression through activation of STAT3 signaling pathway during cancer progression.

  19. Report the presence of aberrantly located LGR5(+) cells coexpressing epithelial markers in the stromal compartment of women with endometriosis. These cells have a statistically significantly different expression profile in deep-infiltrating endometriosis in comparison with other types of endometriosis, independent of the menstrual cycle phase.

  20. Arrb1 reduced the chemotherapy-induced Lgr5 stem cell apoptosis by inhibiting endoplasmic reticulum stress-mediated mitochondrial apoptotic signaling.

LGR5 Antigen-Profil

Protein Überblick

Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.

Genbezeichner und Symbole assoziert mit LGR5

  • leucine-rich repeat containing G protein-coupled receptor 5 L homeolog (lgr5.L) Antikörper
  • leucine rich repeat containing G protein coupled receptor 5 (Lgr5) Antikörper
  • leucine rich repeat containing G protein-coupled receptor 5 (LGR5) Antikörper
  • FEX Antikörper
  • GPR49 Antikörper
  • GPR67 Antikörper
  • GRP49 Antikörper
  • HG38 Antikörper
  • lgr5-a Antikörper
  • lgr5a Antikörper

Bezeichner auf Proteinebene für LGR5

leucine-rich repeat-containing G protein-coupled receptor 5 , leucine-rich repeat-containing G-protein coupled receptor 5A , leucine-rich repeat-containing G-protein coupled receptor 5a , G protein-coupled receptor 49 , G-protein coupled receptor 49 , follicle expressed hormone , leucine-rich repeat-containing G-protein coupled receptor 5 , orphan G-protein coupled receptor FEX , G-protein coupled receptor 67 , G-protein coupled receptor HG38 , orphan G protein-coupled receptor HG38

GENE ID SPEZIES
100526795 Xenopus laevis
14160 Mus musculus
299802 Rattus norvegicus
8549 Homo sapiens
427867 Gallus gallus
Ausgewählte Anbieter für anti-LGR5 (LGR5) Antikörper
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