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The protein encoded by KRT16 is a member of the keratin gene family. Zusätzlich bieten wir Ihnen Keratin 16 Antikörper (150) und Keratin 16 Kits (12) und viele weitere Produktgruppen zu diesem Protein an.
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results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed
inflammatory cytokines promoted Nrf2 (zeige GABPA Proteine) nuclear translocation in psoriatic epidermis, which led to elevated expression of K6, K16, and K17 (zeige KRT17 Proteine), thus promoting keratinocyte proliferation and contributing to the pathogenesis of psoriasis.
The wider spectrum of KRT16 mutations suggests that changes in codons 125, 127, and 132 are most commonly responsible for PC-1 (zeige PCSK1 Proteine) and that proline substitution mutations at codons 127 or 128 may produce more severe disease
analysis of a new p.Leu421Pro (c.1262T>C) mutation in the highly conserved helix termination motif of K16 in a large Spanish family that may have a role in pachyonychia congenita
Keratin 16 regulates innate immunity in response to epidermal barrier breach.
Data established a seven-gene (AR, ESR2 (zeige ESR2 Proteine), GATA3 (zeige GATA3 Proteine), GBX2 (zeige GBX2 Proteine), KRT16, MMP28 (zeige MMP28 Proteine) and WNT11 (zeige WNT11 Proteine)) prognostic signature to define a subset of triple-negative breast cancer (TNBC).
Genotype-phenotype correlations among PC patients with codon-125 mutation in KRT16 were established, while the phenotypes caused by the IVS8-2A>C mutation in KRT6A (zeige KRT6A Proteine) need further studies to confirm the rare feature of fissured tongue
We found that the KRT16 mutation carriers developed plantar keratoderma at a similar age to KRT6A (zeige KRT6A Proteine) carriers wheras KRT6B (zeige KRT6B Proteine) and KRT17 (zeige KRT17 Proteine) carriers were significantly more likely to report later onset.
Phenotypic differences exist between KRT6A (zeige KRT6A Proteine) and KRT16 mutations support adoption of a new classification system.
Patients with p.Asn125Asp and p.Arg127Pro mutations in KRT16 exhibited more severe disease than patients carrying p.Asn125Ser and p.Arg127Cys mutations in terms of age of onset of symptoms, extent of nail (zeige CD244 Proteine) involvement, and impact on daily quality of life.
we show that the loss of Krt16 function in mice causes the development of prominent calluses on the plantar side of front and hind paws, which significantly compromise mobility.
Keratin 6 and keratin 16 may play a role in wrinkle formation.
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
, keratin 16
, Keratin, type I cytoskeletal 17
, cytokeratin 16
, focal non-epidermolytic palmoplantar keratoderma
, keratin, type I cytoskeletal 16
, keratin complex 1, acidic, gene 16
, keratin intermediate filament 16a
, keratin intermediate filament 16b
, keratin 14
, keratin 16 (focal non-epidermolytic palmoplantar keratoderma)
, type I keratin KA16