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IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family. Zusätzlich bieten wir Ihnen IRF6 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 96 products:
Human Polyclonal IRF6 Primary Antibody für ELISA, IHC - ABIN4327608
Hu, Liu, Li, Ozturk, Gurumurthy, Romano, Sinha, Nawshad: TGFβ3 regulates periderm removal through ΔNp63 in the developing palate. in Journal of cellular physiology 2015
Show all 5 Pubmed References
Cow (Bovine) Polyclonal IRF6 Primary Antibody für IHC, WB - ABIN2779406
Iwata, Suzuki, Pelikan, Ho, Sanchez-Lara, Urata, Dixon, Chai: Smad4-Irf6 genetic interaction and TGF?-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. in Development (Cambridge, England) 2013
we performed an association study of AXIN2 (zeige AXIN2 Antikörper), BMP4 (zeige BMP4 Antikörper) and IRF6 gene SNPs with Non-Syndromic Cleft Lip with or without Cleft Palate in an Iranian population and the findings proposed that BMP4 (zeige BMP4 Antikörper) rs17563 polymorphism is associated with reduced risk against Non-Syndromic Cleft Lip with or without Cleft Palate.
Two novel mutations (Arg31Thr and Trp40Glyfs *23) in the IRF6 gene were identified to be causative for Van (zeige TNIP1 Antikörper) der (zeige GDF3 Antikörper) Woude and popliteal pterygium syndromes in 6 Polish families. In the present study no association between the single nucleotide polymorphisms rs7552506, rs2013162, and rs2235375 and the cleft lip and/or palate phenotype was found.
Our results do not support the previously reported association between the A allele of rs642961 and the NSCL (zeige NHLH1 Antikörper) phenotype. However, in the VWS/PPS families, the A allele was a risk allele and was, in a large majority (>80%), transmitted on the same chromosome as the IRF6 mutation.
CCL5 (zeige CCL5 Antikörper) and CXCL11 (zeige CXCL11 Antikörper) expression were also induced in response to the activation of the PKC (zeige PRRT2 Antikörper) pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 (zeige RIPK4 Antikörper) and IRF6. Moreover, gene reporter assays suggested that RIPK4 (zeige RIPK4 Antikörper) induces CCL5 (zeige CCL5 Antikörper) and CXCL11 (zeige CXCL11 Antikörper) expression by stimulating the transactivation of their promoters by IRF6.
IRF6 is aberrantly silenced by DNA methylation (zeige HELLS Antikörper) of the 5' IRF6 CGI in melanoma
In all three affecteds the known pathogenic mutation c.265A>G, p.Lys89Glu in IRF6 was identified. While inter- as well as intra-familial variability has been described in IRF6-related disorders, the occurrence of a typical Van (zeige TNIP1 Antikörper) der (zeige GDF3 Antikörper) Woude Syndrome without any other anomalies as well as a diagnosis of Popliteal pterygium syndrome in the same family is rare.
Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate
Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.
The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1 (zeige NME1 Antikörper)/2 complex and thus the dynamic behavior of epithelia during lip/palate development.
IRF6 dysregulation may be involved in the development of Vulvar Squamous Cell Carcinoma from vulvar lichen sclerosus (VLS). Methylation of the IRF6 promoter may be a marker of cancer risk in patients with VLS.
Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (zeige MYD88 Antikörper) and TBK1 (zeige TBK1 Antikörper), suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.
Authors report that Kruppel-like factor 17 (Klf17 (zeige KLF17 Antikörper)), like Grhl3 (zeige GRHL3 Antikörper), acts downstream of Irf6 in this network in zebrafish periderm.
In zebrafish periderm, grainyhead-like 3 (grhl3 (zeige GRHL3 Antikörper)) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 (zeige GRHL1 Antikörper) and grhl3 (zeige GRHL3 Antikörper) disrupted periderm differentiation in zebrafish.
analysis of zebrafish expression of IRF6
These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.
Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha (zeige CHUK Antikörper) and Irf6.
IRF6 suppresses PPARgamma (zeige PPARG Antikörper) through binding IRF (zeige TRIM63 Antikörper) recognition sites located upstream of the PPARgamma (zeige PPARG Antikörper) coding region. Taken together, the results suggest that an IRF6/PPARgamma (zeige PPARG Antikörper) regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.
Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.
These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP (zeige HAPLN1 Antikörper) and indicate a direct role for the major CLP (zeige HAPLN1 Antikörper) gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.
that downregulation of interferon regulatory factor 6 affords protection against TNI (zeige TNNI2 Antikörper) through Akt (zeige AKT1 Antikörper)-eNOS (zeige NOS3 Antikörper) pathway-mediated antioxidative and anti-inflammatory activity
Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.
TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.
Pvrl1 (zeige PVRL1 Antikörper) is a bona fide target gene of the transcription factor p63 (zeige CKAP4 Antikörper), whereas Pvrl4 (zeige PVRL4 Antikörper) regulation is linked to epidermal differentiation and is under Irf6
Data suggest that Irf6 functions through the RhoA (zeige RHOA Antikörper) pathway to regulate cellular migration.
These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
interferon regulatory factor 6
, interferon regulatory factor 6-like