IRF6 Antikörper (Middle Region)

Produktnummer ABIN2779406

Produktdetails anti-IRF6 Antikörper

Target: IRF6 (Interferon Regulatory Factor 6 (IRF6))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Pferd, Rind (Kuh), Meerschweinchen, Schaf, Zebrafisch (Danio rerio), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRF6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: IPVVARMIYE MFSGDFTRSF DSGSVRLQIS TPDIKDNIVA QLKQLYRILQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against IRF6. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IRF6

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 467 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-IRF6 Antikörper (ABIN2779406)

Iwata, Suzuki, Pelikan, Ho, Sanchez-Lara, Urata, Dixon, Chai: "Smad4-Irf6 genetic interaction and TGF?-mediated IRF6 signaling cascade are crucial for palatal fusion in mice." in: Development (Cambridge, England), Vol. 140, Issue 6, pp. 1220-30, (2013) (PubMed).

Details zu IRF6

Target: IRF6 (Interferon Regulatory Factor 6 (IRF6))

Andere Bezeichnung: IRF6 (IRF6 Produkte)

Synonyme: IRF6 antikoerper, lps antikoerper, pit antikoerper, pps antikoerper, vws antikoerper, ofc6 antikoerper, xIRF-6 antikoerper, DKFZp469E012 antikoerper, LPS antikoerper, OFC6 antikoerper, PIT antikoerper, PPS antikoerper, PPS1 antikoerper, VWS antikoerper, VWS1 antikoerper, zgc:63500 antikoerper, AI876454 antikoerper, E230028I05Rik antikoerper, mirf6 antikoerper, interferon regulatory factor 6 antikoerper, interferon regulatory factor 6 S homeolog antikoerper, IRF6 antikoerper, irf6 antikoerper, irf6.S antikoerper, Irf6 antikoerper

Hintergrund: IRF6 is a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in its gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: LPS, OFC6, PIT, PPS, VWS, VWS1
Protein Interaction Partner: HHV8GK18_gp81, UBC, BNC2, IRF5, IRF8, ZBTB3, RFX3, TLX2, LBP,
Protein Size: 467

Molekulargewicht: 53 kDa

Gen-ID: 3664

NCBI Accession: NM_006147, NP_006138

UniProt: O14896