Insulin-Degrading Enzyme Proteine (IDE)

IDE encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. Zusätzlich bieten wir Ihnen Insulin-Degrading Enzyme Antikörper (154) und Insulin-Degrading Enzyme Kits (58) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IDE 15925  
IDE 25700 P35559
IDE 3416 P14735
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$778.00
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Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$600.88
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Human Cells Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
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Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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Escherichia coli (E. coli) Ratte Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$838.60
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Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
Details

IDE Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Rat (Rattus)
Human , , , ,
, , ,

Am meisten referenzierte Insulin-Degrading Enzyme Proteine

  1. Human IDE Protein expressed in HEK-293 Cells - ABIN2723516 : Kim, Lone, Saghatelian: Analysis of the proteolysis of bioactive peptides using a peptidomics approach. in Nature protocols 2013 (PubMed)

Weitere Proteine zu Insulin-Degrading Enzyme (IDE) Interaktionspartnern

Mouse (Murine) Insulin-Degrading Enzyme (IDE) Interaktionspartner

  1. Study indicated that, in the type 2 diabetes (T2D) and Alzheimer's disease (AD) mice, cAMP/PKA signaling pathway and IDE may participate in the contribute role of T2D in accelerating the pathological process of AD via causing neuronal apoptosis.

  2. Our results found that, in the mice with T2D and AD, the activators of PPARg (zeige PPARG Proteine)/AMPK (zeige PRKAA1 Proteine) signaling pathway significantly increased the expression level of IDE, and decreased the accumulation of Ab40 and Ab42, as well as alleviated the spatial learning and recognition impairments.

  3. elevated IDE expression, in the skeletal muscle, seems to be mediated by activation of AMPK-ACC pathway, in response to exercise

  4. IDE inhibition did notincrease amyloid formation or beta-cell loss.

  5. This study demonstrated that the Decreased IDE and IGF2 expression in the cerebral cortex of pups by early life lead exposure.

  6. Findings show a key role of Pla2g3 (zeige PLA2G3 Proteine) on the reduction of IDE, and suggest that cerebrum specific increase of Pla2g3 (zeige PLA2G3 Proteine) is involved in the initiation and/or progression of Alzheimer disease.

  7. Abeta (zeige APP Proteine) level reduction by CALHM1 (zeige CALHM1 Proteine) could be explained by an increase in extracellular Abeta (zeige APP Proteine) degradation by insulin-degrading enzyme.

  8. Data suggest that protein restriction down-regulates expression of insulysin (insulin degrading enzyme) in liver and subsequently reduced insulin (zeige INS Proteine) clearance.

  9. IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated Abeta (zeige APP Proteine) and RAGE (zeige AGER Proteine), and higher serum cholesterol in male, Ldlr (zeige LDLR Proteine)(-/-) mice.

  10. The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells.

Human Insulin-Degrading Enzyme (IDE) Interaktionspartner

  1. These results support the hypothesis that IDE gene expression in different areas of Alzheimer's patient's brains.

  2. People with allelic variation in four genes related to cardiovascular diseases and metabolism were more likely to die: apolipoprotein (APO (zeige C9orf3 Proteine))C1 GG and AG carriers, APOE (zeige APOE Proteine) varepsilon4 carriers, insulin-degrading enzyme (IDE) TC carriers, and phosphatidylinositol 3-kinase (PI3KCB) GG carriers.

  3. Data suggest the possibility of development of insulin-degrading enzyme (IDE)-based drugs for the treatment of the late-onset form of Alzheimer's disease (AD).

  4. the mechanistic and molecular features of IDE-26S proteasome (zeige Psmd4 Proteine) interaction in a cell experimental model, is reported.

  5. No significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with Alzheimer disease.

  6. results demonstrate that the polymorphisms rs1887922 and rs1999764 of the IDE gene are associated with late-onset Alzheimer disease susceptibility in the Xinjiang Han population

  7. Cognitive impairment is more frequent among those exposed to the C allele of the rs2209972 SNP of the insulin degrading enzyme gene.

  8. IDE does not play a major role in MHC class I antigen processing, confirming the dominant and almost exclusive role of the proteasome in cytosolic production of MHC class I ligands.

  9. using combinational in silico investigations, study identified that pathogenic nonsynonymous mutations corresponding to p.I54F, p.P122T, p.T533R, p.P581A and p.Y609A have more potential role in structural and functional deviations of IDE activity

  10. Our study provided evidence to IDE, PON1 (zeige PON1 Proteine), WFS1 (zeige WFS1 Proteine), POU2F1 (zeige POU2F1 Proteine), IL1alpha (zeige IL1A Proteine) and IL1beta (zeige IL1B Proteine) associated with T2D in Pakistanis.

Insulin-Degrading Enzyme (IDE) Protein Überblick

Protein Überblick

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Genbezeichner und Symbole assoziert mit Insulin-Degrading Enzyme Proteine (IDE)

  • insulin degrading enzyme (IDE)
  • insulin-degrading enzyme (ide)
  • insulin-degrading enzyme (LOC591315)
  • insulin-degrading enzyme (CC1G_01115)
  • insulin-degrading enzyme (Bm1_26615)
  • insulin-degrading enzyme (PTRG_10875)
  • metallopeptidase (SJAG_01430)
  • insulin-degrading enzyme (EBI_21700)
  • insulin-degrading enzyme (VDBG_06702)
  • insulin-degrading enzyme (LOAG_08082)
  • insulin-degrading enzyme (PGTG_04982)
  • insulin-degrading enzyme (Tsp_00424)
  • insulin degrading enzyme (Ide)
  • 1300012G03Rik Protein
  • 4833415K22Rik Protein
  • AA675336 Protein
  • AI507533 Protein
  • IDE Protein
  • INSDEGM Protein
  • INSULYSIN Protein
  • zgc:162603 Protein

Bezeichner auf Proteinebene für Insulin-Degrading Enzyme Proteine (IDE)

insulysin , insulin-degrading enzyme , insulin-degrading enzyme-like , insulin protease , insulinase , Abeta-degrading protease

GENE ID SPEZIES
450608 Pan troglodytes
561390 Danio rerio
591315 Strongylocentrotus purpuratus
698640 Macaca mulatta
6009544 Coprinopsis cinerea okayama7130
6100223 Brugia malayi
6349187 Pyrenophora tritici-repentis Pt-1C-BFP
7051385 Schizosaccharomyces japonicus yFS275
8641122 Enterocytozoon bieneusi H348
9537184 Verticillium alfalfae VaMs.102
100071303 Equus caballus
100385143 Callithrix jacchus
100434053 Pongo abelii
100482236 Ailuropoda melanoleuca
9945508 Loa loa
10530847 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10901673 Trichinella spiralis
15925 Mus musculus
25700 Rattus norvegicus
3416 Homo sapiens
477768 Canis lupus familiaris
100341888 Oryctolagus cuniculus
100719651 Cavia porcellus
423814 Gallus gallus
100155309 Sus scrofa
523752 Bos taurus
101104194 Ovis aries
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