anti-Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) Antikörper

The protein encoded by INPP5E is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Maus INPP5E INPP5E 64436 Q9JII1
Anti-Ratte INPP5E INPP5E 114089  
Anti-Human INPP5E INPP5E 56623 Q9NRR6
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Top anti-INPP5E Antikörper auf antikoerper-online.de

Showing 10 out of 18 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Fledermaus Kaninchen Unkonjugiert IHC (p) Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) 0.05 mg Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: INPP5E Antibody [NBP2-49463] - Analysis of human cell line U-2 OS shows positivity in the Golgi apparatus, cell junctions & nucleus but excluded from the nucleoli. Immunohistochemistry-Paraffin: INPP5E Antibody [NBP2-49463] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Maus Unkonjugiert WB Western Blot analysis of INPP5E expression in transfected 293T cell line by INPP5E MaxPab polyclonal antibody.<br><br>Lane 1: INPP5E transfected lysate(70.84 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Maus Unkonjugiert WB   50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$837.83
Details
Human Kaninchen Unkonjugiert WB Western Blot analysis of INPP5E expression in transfected 293T cell line by INPP5E MaxPab polyclonal antibody.<br><br>Lane 1: INPP5E transfected lysate(70.2 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$425.71
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$581.17
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, IP, WB   100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$380.00
Details
Human Kaninchen Unkonjugiert IF, IHC, WB   100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$743.29
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$614.84
Details

Weitere Antikörper gegen INPP5E Interaktionspartner

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) Interaktionspartner

  1. Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT (zeige AKT1 Antikörper)/GSK3beta signaling axis at cilia in SHH (zeige SHH Antikörper)-dependent medulloblastoma that is regulated by INPP5E to maintain tumor cell cilia, promote SHH (zeige SHH Antikörper) signaling and thereby medulloblastoma progression.

  2. we identify Inpp5e as an essential inhibitor of the PI3K/Akt (zeige AKT1 Antikörper)/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD (zeige PRKD1 Antikörper)) suppression

  3. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.

  4. INPP5E is an essential point of convergence between Hedgehog (zeige SHH Antikörper) and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog (zeige SHH Antikörper)-dependent embryonic development.

  5. the affinity to PDE6delta and the release by Arl2 (zeige ARL2 Antikörper)/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.

  6. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  7. Inpp5e, through functional interactions with Rab20 (zeige RAB20 Antikörper) on the phagosome, activates Rab5 (zeige RAB5A Antikörper), which, in turn, increases PtdIns3P and delays phagosome acidification.

  8. Inpp5e and SHIP1 (zeige INPP5D Antikörper) exhibit specificity in regulating FcgammaR- versus CR3 (zeige ITGAM Antikörper)-stimulated phagocytosis by controlling the amplitude and duration of PtdIns(3,4,5)P(3) at the phagocytic cup.

  9. Inpp5e mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in the mouse.

Human Inositol Polyphosphate-5-Phosphatase, 72 KDa (INPP5E) Interaktionspartner

  1. INPP5E associates with the N-terminus of RPGR (zeige RPGR Antikörper) and trafficking of INPP5E to cilia is dependent upon the ciliary localization of RPGR (zeige RPGR Antikörper).

  2. we identify Inpp5e as an essential inhibitor of the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD (zeige PRKD1 Antikörper)) suppression

  3. ARL13B (zeige ARL13B Antikörper) regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E.

  4. In neuronal cells, INPP5E knockdown strongly inhibited autophagy by impairing the autophagosome-lysosome fusion step.

  5. INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.

  6. INPP5E is an essential point of convergence between Hedgehog (zeige SHH Antikörper) and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog (zeige SHH Antikörper)-dependent embryonic development.

  7. MKS1 (zeige MKS1 Antikörper) functions in the transition zone at the base of the cilium to regulate ciliary INPP5E content.

  8. PIPKIgamma and INPP5E localize to the centrosome and coordinate the initiation of ciliogenesis.

  9. These findings establish the first direct link between AURKA (zeige AURKA Antikörper) and phosphoinositide signaling and suggest that the function of INPP5E in cilia is at least partly mediated by its interactions with AURKA (zeige AURKA Antikörper)

  10. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D (zeige PDE6D Antikörper). Mutant PDE6D (zeige PDE6D Antikörper) shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues.

INPP5E Antigen-Profil

Protein Überblick

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome\; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.

Genbezeichner und Symbole assoziert mit INPP5E

  • inositol polyphosphate-5-phosphatase E (Inpp5e) Antikörper
  • inositol polyphosphate-5-phosphatase E (INPP5E) Antikörper
  • 72kDa Antikörper
  • 1200002L24Rik Antikörper
  • CORS1 Antikörper
  • CPD4 Antikörper
  • JBTS1 Antikörper
  • mKIAA0123 Antikörper
  • MORMS Antikörper
  • PMPCA Antikörper
  • PPI5PIV Antikörper

Bezeichner auf Proteinebene für INPP5E

72 kDa inositol polyphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase, 72 kDa , phosphatidylinositol 4,5-bisphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphatase type IV , phosphatidylinositol-4,5-bisphosphate 5-phosphatase , 5-phosphatase that induces arborization , inositol polyphosphate 5-phosphatase , pharbin , phosphatidylinositol (4,5) bisphosphate 5-phosphatase , inositol polyphosphate-5-phosphatase E , peptidase (mitochondrial processing) alpha

GENE ID SPEZIES
64436 Mus musculus
114089 Rattus norvegicus
56623 Homo sapiens
748603 Pan troglodytes
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