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may be involved in osteoblast recruitment into growing bone tissue. Zusätzlich bieten wir Ihnen Hemogen Antikörper (55) und und viele weitere Produktgruppen zu diesem Protein an.
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HOXB4 (zeige HOXB4 ELISA Kits) binds to the Hemgn promoter region ex vivo & in vivo. Overexpressed Hemgn in bone marrow cells promoted cellular expansion in liquid cultures & increased self-renewal of myeloid colony-forming units.
Alternative promoters and polyadenylation regulate tissue-specific expression of Hemogen isoforms during hematopoiesis and spermatogenesis
EDAG is a key transcriptional regulator in maintaining the homeostasis of hematopoietic lineage commitment
Using ex vivo culture and HSC transplantation models, study finds that EDAG enhances proliferative potential of human cord blood CD34 (zeige CD34 ELISA Kits)+ cells, increases survival, prevents cell apoptosis and promotes their repopulating capacity. EDAG overexpression induces rapid entry of CD34 (zeige CD34 ELISA Kits)+ cells into the cell cycle. Gene expression profile analysis shows that EDAG knockdown leads to down-regulation of positive cell cycle regulators.
a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO (zeige MPO ELISA Kits), CEACAM8, CRISP3 (zeige CRISP3 ELISA Kits), MS4A3, CEACAM6, HEMGN, and MMP8 (zeige MMP8 ELISA Kits)
EDAG-1 regulates the proliferation and apoptosis of thyroid carcinoma via the PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) signaling pathway.
EDAG forms complex with GATA1 (zeige GATA1 ELISA Kits) and p300 (zeige EP300 ELISA Kits) and increases GATA1 (zeige GATA1 ELISA Kits) acetylation and transcriptional activity by facilitating the interaction between GATA1 (zeige GATA1 ELISA Kits) and p300 (zeige EP300 ELISA Kits)
EDAG enhances the protein stability of NPM1 (zeige NPM1 ELISA Kits) via binding to NPM1 (zeige NPM1 ELISA Kits), which plays a critical role in the anti-apoptosis of leukaemia cells.
EDAG functions as a positive regulator of erythroid/megakaryocytic differentiation in 32D cells associated with the induction of GATA-1 (zeige GATA1 ELISA Kits) and its target genes
results suggest a novel function of nuclear negative differentiation regulator (NDR) protein in regulating hematopoietic cell development [NDR]
These results suggest that EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of NF-kappa B (zeige NFKB1 ELISA Kits).
Hemgn promoter contains critical regulatory elements for its transcription in hematopoietic tissues and Hemgn is a direct target of GATA1 (zeige GATA1 ELISA Kits) in leukemia cells
The stable transfected cells were identified with RT-PCR and the effect of EDAG/siRNA on the growth of the human erythroleukemia cell line HEL was analyzed.
may be involved in osteoblast recruitment into growing bone tissue
, hemopoietic gene protein
, negative differentiation regulator protein
, nuclear protein
, erythroid differentiation gene 1
, erythroid differentiation-associated gene protein