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GGPS1 is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. Zusätzlich bieten wir Ihnen GGPS1 Antikörper (127) und GGPS1 Proteine (19) und viele weitere Produktgruppen zu diesem Protein an.
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GGPPS11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids. Both gene co-expression and protein-protein interaction likely contribute to the channeling of geranylgeranyl diphosphate (GGPP) by GGPPS11.
GGPS1 is a key gene in the chlorophyll biosynthetic pathway.
results may support a model in which accumulation of susceptibility variants (including some in relevant genes, notably GGPS1) may lead to a possible genetic component of predisposition to atypical femoral fractures.
GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC.
Egr-1 most likely does not induce the constitutive activation of Erk1/2 through its target gene GGPS1.
the Egr-1/GGPPS/Erk1/2 pathway is responsible for insulin resistance during hyperinsulinism
these results reveal a new EGR-1/GGPPS/MAPK signaling pathway that controls cigarette smoke-induced pulmonary inflammation.
Study suggested that GGPS1 -8188A ins/del polymorphism may confer susceptibility to femoral neck BMD response to bisphosphonate therapy in Korean women.
crystal structure; it reveals that three dimers join together to form a propeller-bladed hexameric molecule with a mass of approximately 200 kDa
Farnesyltranstransferase mutations are associated with lonafarnib resistance
results indicate that the active form of GGPS in the solution is an octamer rather than hexamer or dimer
Evidence for a non-membrane bound isoform of geranylgeranyl diphosphate synthase 1 in rat.
Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation
the specific deletion of Ggps1, using the Collagen 2-CreER(T2) mice, will accelerate the fracture healing process by activating the Bmp2/Smad-dependent Runx2 pathway.
Depletion of GGPP in mouse oocytes impaired the proliferation of granulosa cells, primary-secondary follicle transition and female fertility. GGPP depletion inhibited Rho GTPase geranylgeranylation and its GTPase activity.
our data suggest that GGPPS is essential for maintaining fetal lung branching morphogenesis, which is possibly through regulating K-Ras prenylation.
GGPPS-controlled protein geranylgeranylation, which regulates formation of the insulin granule docked pool, is critical for beta cell function and insulin release during the development of type 2 diabetes mellitus
findings imply that GGPPS deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity.
Data suggest that farnesyltransferase might constitute a target in the management of severe acute pancreatitis (AP).
the impact of deleting one copy of FT or GGT on the development of amyloid-beta (Abeta)-associated neuropathology and learning/memory impairments in APPPS1 double transgenic mice.
The authors show that an early response transcription factor Egr-1 could tilt the signalling balance by blocking PI3K/Akt signalling through PTEN and augmenting Erk/MAPK signalling through GGPPS, resulting in insulin resistance in adipocytes.
GGPP is critical for the cell-to-cell contact-induced differentiation, in which the down-regulation of GGPPS might be involved.
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
geranylgeranyl pyrophosphate synthase 1
, geranylgeranyl pyrophosphate synthetase
, geranyl pyrophosphate synthase
, geranylgeranyl pyrophosphate synthase,chloroplastic
, geranylgeranyl diphosphate synthase 1
, (2E,6E)-farnesyl diphosphate synthase
, GGPP synthase
, farnesyl diphosphate synthase
, geranylgeranyl pyrophosphate synthase
, GGPP synthetase