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GGPS1 is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. Zusätzlich bieten wir Ihnen GGPS1 Antikörper (127) und GGPS1 Proteine (19) und viele weitere Produktgruppen zu diesem Protein an.
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GGPS1 is a key gene in the chlorophyll biosynthetic pathway.
results may support a model in which accumulation of susceptibility variants (including some in relevant genes, notably GGPS1) may lead to a possible genetic component of predisposition to atypical femoral fractures.
GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC.
Egr-1 (zeige EGR1 ELISA Kits) most likely does not induce the constitutive activation of Erk1/2 (zeige MAPK1/3 ELISA Kits) through its target gene GGPS1.
the Egr-1 (zeige EGR1 ELISA Kits)/GGPPS/Erk1/2 (zeige MAPK1/3 ELISA Kits) pathway is responsible for insulin (zeige INS ELISA Kits) resistance during hyperinsulinism
these results reveal a new EGR-1 (zeige EGR1 ELISA Kits)/GGPPS/MAPK (zeige MAPK1 ELISA Kits) signaling pathway that controls cigarette smoke-induced pulmonary inflammation.
Study suggested that GGPS1 -8188A ins (zeige INS ELISA Kits)/del polymorphism may confer susceptibility to femoral neck BMD response to bisphosphonate therapy in Korean women.
Farnesyltranstransferase mutations are associated with lonafarnib resistance
Evidence for a non-membrane bound isoform of geranylgeranyl diphosphate synthase 1 in rat.
Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation
the specific deletion of Ggps1, using the Collagen 2-CreER(T2) mice, will accelerate the fracture healing process by activating the Bmp2 (zeige BMP2 ELISA Kits)/Smad (zeige SMAD1 ELISA Kits)-dependent Runx2 (zeige RUNX2 ELISA Kits) pathway.
Depletion of GGPP in mouse oocytes impaired the proliferation of granulosa cells, primary-secondary follicle transition and female fertility. GGPP depletion inhibited Rho GTPase (zeige RACGAP1 ELISA Kits) geranylgeranylation and its GTPase (zeige RACGAP1 ELISA Kits) activity.
our data suggest that GGPPS is essential for maintaining fetal lung branching morphogenesis, which is possibly through regulating K-Ras prenylation.
GGPPS-controlled protein geranylgeranylation, which regulates formation of the insulin (zeige INS ELISA Kits) granule docked pool, is critical for beta cell function and insulin (zeige INS ELISA Kits) release during the development of type 2 diabetes mellitus
findings imply that GGPPS deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity.
the impact of deleting one copy of FT or GGT (zeige GGT1 ELISA Kits) on the development of amyloid-beta (Abeta (zeige APP ELISA Kits))-associated neuropathology and learning/memory impairments in APPPS1 double transgenic mice.
The authors show that an early response transcription factor Egr-1 (zeige EGR1 ELISA Kits) could tilt the signalling balance by blocking PI3K/Akt (zeige AKT1 ELISA Kits) signalling through PTEN and augmenting Erk/MAPK (zeige MAPK1 ELISA Kits) signalling through GGPPS, resulting in insulin (zeige INS ELISA Kits) resistance in adipocytes.
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
geranylgeranyl pyrophosphate synthase 1
, geranylgeranyl pyrophosphate synthetase
, geranyl pyrophosphate synthase
, geranylgeranyl pyrophosphate synthase,chloroplastic
, geranylgeranyl diphosphate synthase 1
, (2E,6E)-farnesyl diphosphate synthase
, GGPP synthase
, farnesyl diphosphate synthase
, geranylgeranyl pyrophosphate synthase
, GGPP synthetase