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GJD2 is a member of the connexin gene family that is expressed predominantly in mammalian neurons. Zusätzlich bieten wir Ihnen Gap Junction Protein, delta 2, 36kDa Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal GJD2 Primary Antibody für IHC, IHC (fro) - ABIN4892179
Moore, Zhou, Sirois, Belinsky, Zecevic, Antic: Connexin hemichannels contribute to spontaneous electrical activity in the human fetal cortex. in Proceedings of the National Academy of Sciences of the United States of America 2014
Study suggests that Cx36 (GJD2) expression in the AII (zeige NLRP3 Antikörper)-mediated rod pathway is activity dependent in the developing rabbit retina
In mice, strain differences were found, such that punctate labelling for Cx36 was differentially distributed in the molecular layer of C57BL/6 vs. CD1 (zeige CCND1 Antikörper) mice. Cx36-puncta were localized to processes of stellate cells and other cerebellar interneurons. The vast majority of Cx36-puncta co-localized with Cx45 (zeige GJC1 Antikörper)-puncta, which in turn was associated with the scaffolding protein zonula occludens-1 (zeige TJP1 Antikörper).
Cx36 deletion therefore disrupts normal regulation of sympathetic outflow with effects on cardiovascular parameters.
Deletion of connexin 36 increased the frequency and shifted the amplitude distributions of miniature inhibitory post synaptic potentials.
retinal aberrant activity was reduced in the rd10 (zeige PDE6B Antikörper)/Cx36KO mice compared to rd10 (zeige PDE6B Antikörper) controls, a direct evidence for involvement of Cx36-containing gap junctions in generating aberrant activity in RD.
The results suggest that electrical synapses formed by Cx36-containing gap junctions occur in most of the widely distributed centers of the auditory system.
The resilts of this study showed that the phosphorylation state of Cx36 as a key biochemical step at the crossroad of light-dark and circadian regulatory pathways that control photoreceptor coupling.
The magnitudes of the 2f1 (zeige KLRG1 Antikörper)-f2 distortion products were not different between Cx36 knockout and wild-type mice, suggesting similar cochlear function in the two groups
Mg(2 (zeige MCOLN1 Antikörper)+)-dependent synaptic plasticity of Cx36-containing electrical synapses could underlie neuronal circuit reconfiguration via changes in brain energy metabolism that affects neuronal levels of intracellular ATP and [Mg(2 (zeige MCOLN1 Antikörper)+)]i.
Gene expression data indicate that EPCs, or their soluble products, modulate the expression of the beta-cell surface molecule connexin 36 and affect glucose-stimulated insulin (zeige INS Antikörper) release in vitro.
Some neurons exhibit at least two discriminatory mechanisms for assembling Cx36 into gap junctions.
Study shows that human outer retina displays a diverse cohort of connexin 36 gap junctions that follows the general mammalian scheme and display a great functional diversity.
Sparse punctate Cx36 expression was seen in the myenteric plexus in nerve trunks and some platelet-derived growth factor receptor-alpha (zeige PDGFRA Antikörper)-positive cell and interstitial cells of Cajal fibers in patients with Hirschsprung's disease.
Genetic variants in ZC3H11B, RSPO1, and GJD2 are associated with susceptibility to the development of high myopia in a Han Chinese population.
It was shown that the decreased level of the examined neuronal proteins was accompanied by the impaired coexpression of synaptophysin (zeige SYP Antikörper)/neurofilaments and Cx36 in the series of astrocytomas--anaplastic astrocytomas--glioblastomas.
In this study, there was no association of the analyzed SNPs located in RASGRF1 (zeige RASGRF1 Antikörper). GJD2, and ACTC1 (zeige ACTC1 Antikörper) with pathological myopia.
Three SNP alleles in BRD2 (zeige BRD2 Antikörper), Cx-36, and ME2 (zeige CELSR1 Antikörper) and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy.
Cx36 GJs are highly cation-selective and should exhibit relatively low permeability to numerous vital negatively charged metabolites and high permeability to potassium ion, a major charge carrier in cell-cell communication.
A polymorphism of Cx36 gene is associated to certain forms of human diabetes
connexin genes Gjd2 coding for mCx36, Gjc1 (zeige GJC1 Antikörper) coding for mCx45 and Gja10 (zeige GJA9 Antikörper) coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59 (zeige GJA9 Antikörper)) and GJA10 (Cx62 (zeige GJa10 Antikörper)), could be detected at least as transcript isoforms in the human retina.
Variations in GJD2 is associated with refractive errors and myopia.
Interneuronal communication at gap junctions made by connexin 36 may not be regulated by direct phosphorylation of connexin 36, but possibly by phosphorylation of associated proteins.
This gene encodes a member of the connexin protein family. Connexins are gap junction proteins which are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. The channels formed by this protein allow cationic molecule exchange between human beta cells and may function in the regulation of insulin secretion.
, gap junction protein, alpha 9, 36kDa
, gap junction protein, delta 2, 36kDa
, gap junction delta-2 protein
, gap junction protein, alpha 9, 59kDa
, gap junction protein, alpha 10, 62kDa
, gap junction alpha-10 protein-like
, gap junction alpha-9 protein-like
, gap junction alpha-9 protein
, gap junction membrane channel protein alpha 9
, gap junction protein, alpha 9
, connexin 36
, connexin 35.1
, gap junction channel-forming protein