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anti-GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Antikörper

GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Zusätzlich bieten wir Ihnen GLE1 RNA Export Mediator Homolog (Yeast) Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GLE1 2733 Q53GS7
GLE1 362098 Q4KLN4
GLE1 74412 Q8R322
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Top anti-GLE1 RNA Export Mediator Homolog (Yeast) Antikörper auf antikoerper-online.de

Showing 10 out of 51 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-GLE1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Human Placenta 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image GLE1 antibody detects GLE1 protein at cytoplasm and nucleus in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. GLE1 antibody , diluted at 1:500. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Pferd Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-GLE1 / GLE1L antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IHC, WB Immunohistochemistry-Paraffin: GLE1 Antibody [NBP1-32714] - Paraffin-embedded Cal27 xenograft, using antibody at 1:500 dilution. Immunocytochemistry/Immunofluorescence: GLE1 Antibody [NBP1-32714] - Paraformaldehyde-fixed HeLa, using GLE1 antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with an alpha Tubulin antibody (Red) at 1:2500. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$474.10
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$474.10
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded rat testis, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with GLE1 Polyclonal Antibody, Unconjugated at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$306.90
Details

Weitere Antikörper gegen GLE1 RNA Export Mediator Homolog (Yeast) Interaktionspartner

Human GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Interaktionspartner

  1. Pathogenic variants in the GLE1 gene are rare in Chinese ALS patients.

  2. Data indicate 2 siblings with a homozygous p.I684T mutation in RNA export mediator (GLE1).

  3. These results imply that DBP5 (zeige SON Antikörper), GLE1 and IP6 (zeige GPRIN2 Antikörper) have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5 (zeige SON Antikörper), GLE1 and IPPK (zeige IPPK Antikörper) in intracellular mRNA metabolism.

  4. We identified bi-allelic mutations in GLE1 in two unrelated individuals with motor delays, feeding difficulties, and respiratory insufficiency who survived beyond the perinatal period. Each affected child had missense variants predicted to result in amino acid substitutions near the C-terminus of GLE1 that are predicted to disrupt protein-protein interaction or GLE1 protein targeting.

  5. It was concluded that the amyotrophic lateral sclerosis-linked Gle1-c.1965-2A>C mutation generates a protein isoform capable of both Gle1A- and Gle1B-ascribed functions, and thereby uncoupled from normal mechanisms of Gle1 regulation.

  6. We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein

  7. Restoration of miR (zeige MLXIP Antikörper)-127-3p and miR (zeige MLXIP Antikörper)-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1 (zeige UBXN11 Antikörper), GLE1 and PDIA6 (zeige PDIA6 Antikörper).

  8. We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis.

  9. Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review]

  10. Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1.

GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Antigen-Profil

Protein Überblick

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit GLE1

  • CG14749 gene product from transcript CG14749-RA (CG14749) Antikörper
  • nucleoporin GLE1 (CpipJ_CPIJ014147) Antikörper
  • RNA export factor Gle1 (SJAG_03847) Antikörper
  • GLE1, RNA export mediator (GLE1) Antikörper
  • GLE1 RNA export mediator (Gle1) Antikörper
  • GLE1 RNA export mediator (yeast) (Gle1) Antikörper
  • 4933405K21Rik Antikörper
  • AA553313 Antikörper
  • Dmel\\CG14749 Antikörper
  • GLE1 Antikörper
  • Gle1l Antikörper
  • hGLE1 Antikörper
  • LCCS Antikörper
  • LCCS1 Antikörper

Bezeichner auf Proteinebene für GLE1

CG14749-PA , nucleoporin GLE1 , GLE1 RNA export mediator homolog , GLE1-like protein , GLE1-like, RNA export mediator , GLE1 RNA export mediator-like (yeast

GENE ID SPEZIES
35849 Drosophila melanogaster
6047573 Culex quinquefasciatus
7050485 Schizosaccharomyces japonicus yFS275
417212 Gallus gallus
2733 Homo sapiens
362098 Rattus norvegicus
74412 Mus musculus
480704 Canis lupus familiaris
540982 Bos taurus
100172586 Pongo abelii
Ausgewählte Anbieter für anti-GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Antikörper
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