GLE1 Antikörper (AA 611-698)

Produktnummer ABIN1714807

Produktdetails anti-GLE1 Antikörper

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Bindungsspezifität: AA 611-698

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLE1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GLE1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu GLE1

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Andere Bezeichnung: GLE1 (GLE1 Produkte)

Synonyme: Dmel\\CG14749 antikoerper, GLE1 antikoerper, GLE1L antikoerper, LCCS antikoerper, LCCS1 antikoerper, hGLE1 antikoerper, Gle1l antikoerper, 4933405K21Rik antikoerper, AA553313 antikoerper, CG14749 gene product from transcript CG14749-RA antikoerper, nucleoporin GLE1 antikoerper, RNA export factor Gle1 antikoerper, GLE1, RNA export mediator antikoerper, GLE1 RNA export mediator antikoerper, GLE1 RNA export mediator (yeast) antikoerper, CG14749 antikoerper, CpipJ_CPIJ014147 antikoerper, SJAG_03847 antikoerper, GLE1 antikoerper, Gle1 antikoerper

Hintergrund:

Synonyms: GLE 1, GLE1, GLE1 like protein, GLE1 like RNA export mediator, GLE1 RNA export mediator homolog, GLE1 RNA export mediator like yeast, GLE1-like protein, GLE1_HUMAN, GLE1L, hGLE1, LCCS 1, LCCS, LCCS1, Nucleoporin GLE1.

Background: Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors that mediate protein passage through the nuclear pore complex (NPC). Gle1, also known as GLE1L, is a 698 amino acid protein that localizes to both the nucleus and the cytoplasm and belongs to the Gle1 family. Expressed as two alternatively spliced isoforms, Gle1 associates with the NPC and is required for the transport of poly(A)-containing mRNAs from the nucleus to the cytoplasm. Defects in the gene encoding Gle1 are the cause of lethal congenital contracture syndrome type 1 (LCCS1) and lethal arthrogryposis with anterior horn cell disease (LAAHD), the former of which is characterized by early fetal hydrops and akinesia, micrognatia, pulmonary hypoplasia, pterygia and prenatal death, while the latter is associated with respiratory failure.

Gen-ID: 2733