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Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. Zusätzlich bieten wir Ihnen GFRA2 Proteine (17) und GFRA2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET (zeige RET Antikörper) tyrosine kinase (zeige TXK Antikörper).
High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance.
GFRA2 variants associated with diabetic neuropathic pain.
The study shows co-localization of RET (zeige RET Antikörper) with GFRA1 (zeige GFRA1 Antikörper) and GFRA2 in myenteric ganglia of the adult human colon.
Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms.
GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia.
This study found nominally-significant evidence for interactions between GFRA1 (zeige GFRA1 Antikörper), 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.
Both GFR (zeige RAPGEF5 Antikörper) alpha2a and GFR (zeige RAPGEF5 Antikörper) alpha2c, but not GFR (zeige RAPGEF5 Antikörper) alpha2b (zeige ADRA2B Antikörper), promote neurite outgrowth in transfected Neuro2A cells.
The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET (zeige RET Antikörper) tyrosine kinase (zeige TYRO3 Antikörper).
Ret (zeige RET Antikörper) and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later.
STAT3 (zeige STAT3 Antikörper) phosphorylation by neurturin (zeige NRTN Antikörper) was found to be mediated specifically by GFRalpha2c and RET9 (zeige RET Antikörper) isoforms.
Cholinergic innervation of gastric mucosa depends on neurturin (zeige NRTN Antikörper)-GFRalpha2 signalling but is dispensable for gastrin (zeige GAST Antikörper) secretion and for basal and maximal acid output
our data demonstrate that RET (zeige RET Antikörper)/GFRalpha signals are dispensable for thymic T cell development in vivo
Transduction-function role for GFR (zeige RAPGEF5 Antikörper) alpha2/neurturin (zeige NRTN Antikörper) signalling in a specific class of sensory neurons.
The cholinergic subpopulation of sympathetic neurons requires GFR alpha 2 signaling for soma size and for growth or maintenance of target innervation.
Demonstrate a role for GFRalpha2-expressing enteric neurons in the downstream signaling of the glucagon (zeige GCG Antikörper)-like peptides to inhibit GI motility, but not in intestinal growth.
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.
GDNF family receptor alpha-2
, GDNF receptor beta
, GFR-alpha 2
, PI-linked cell-surface accessory protein
, RET ligand 2
, TGF-beta-related neurotrophic factor receptor 2
, TRN receptor, GPI-anchored
, glial cell line derived neurotrophic factor receptor, beta
, neurturin receptor alpha
, GDNF receptor alpha-2
, GFR alpha 2
, GFR alpha-2
, CDC42 binding protein kinase alpha (DMPK-like)
, glial cell line derived neurotrophic factor family receptor alpha 2
, tyrosine kinase receptor ligand 2
, GDNF family receptor alpha 2
, GDNF family receptor alpha-2-like