Fused in Sarcoma Proteine (FUS)

FUS encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. Zusätzlich bieten wir Ihnen FUS Antikörper (39) und FUS Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
FUS 2521 P35637
Maus FUS FUS 233908 P56959
Ratte FUS FUS 317385  
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Top FUS Proteine auf antikoerper-online.de

Showing 2 out of 2 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$814.00
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Escherichia coli (E. coli) Human GST tag Fused in Sarcoma (FUS) (AA 1-198), (partial) protein (GST tag) 1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$1,842.50
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FUS Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,

Am meisten referenzierte FUS Proteine

  1. Human FUS Protein expressed in HEK-293 Cells - ABIN2721461 : Groen, Fumoto, Blokhuis, Engelen-Lee, Zhou, van den Heuvel, Koppers, van Diggelen, van Heest, Demmers, Kirby, Shaw, Aronica, Spliet, Veldink, van den Berg, Pasterkamp: ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN. in Human molecular genetics 2013 (PubMed)
    Show all 3 Pubmed References

Weitere Proteine zu Fused in Sarcoma (FUS) Interaktionspartnern

Human Fused in Sarcoma (FUS) Interaktionspartner

  1. more selective group of neurons appears to be affected in frontotemporal lobar degeneration (FTLD)-TDP and FTLD-FUS than in FTLD-tau

  2. Taken together, FUS RNA-recognition motif appears to play a crucial role in exaggerating the physiological/reversible self-assembly into pathological/irreversible fibrillization, thus contributing to manifestation of FUS cytotoxicity.

  3. Fus is a binding partner of FMRP (zeige FMR1 Proteine).

  4. Study demonstrates that FUS mutants, but not WT forms, impair fast axonal transport (FAT) in brain tissue of patients with ALS (zeige IGFALS Proteine), through a mechanism dependent on activation of p38 MAPK (zeige MAPK14 Proteine).

  5. In human stem (zeige TAF15 Proteine) cell-derived motor neurons, the RNA profile associated with concomitant loss of both TAF15 and FUS resembles that observed in the (zeige TAF15 Proteine)presence of the amyotrophic lateral sclerosis (ALS)-associated mutation FUS R521G, but co (zeige TARDBP Proteine)ntrasts with late-stage sporadic ALS patients.

  6. FUS P525L mutation alters transcriptome and microRNA pathways in motor neurons with implications for ALS pathogenesis.

  7. This study showed that in fibroblasts of FUS P525L mutation carriers, FUS mislocalized to the cytoplasm where it redistributed into stress granules with likely a dose effect.

  8. Results find that mutant but not wild-type FUS decreased dendritic growth, mRNA levels, and protein synthesis in dendrites. These data suggest that cytoplasmic FUS aggregates trap mRNA and its transporters, impairing dendritic mRNA trafficking and translation, in turn leading to the disruption of dendritic homeostasis and the development of frontotemporal dementia phenotypes.

  9. activation of the IGF-IR/PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling system is a common pattern in MLS which appears to be transcriptionally controlled, at least in part by induction of IGF2 gene transcription in a FUS-DDIT3 (zeige DDIT3 Proteine)-dependent manner.

  10. SOD1 mutations were present in 20% of familial amyotrophic lateral sclerosis (ALS) patients and 1.9% of sporadic ALS patients, while FUS mutations were responsible for 13.3% of familial ALS cases, and TARDBP mutations were rare in either familial or sporadic ALS cases.

Mouse (Murine) Fused in Sarcoma (FUS) Interaktionspartner

  1. FUS and TAF15 (zeige TAF15 Proteine) exhibit similar global RNA interaction profiles in vivo, but affect a strikingly small subset of common genes. Unexpectedly, TAF15 (zeige TAF15 Proteine) influences a small fraction of amyotrophic lateral sclerosis events compared with TDP-43 (zeige TARDBP Proteine) and FUS in the mouse CNS.

  2. FUS and the ELAV (zeige ELAVL4 Proteine)-like proteins ELAVL4 (zeige ELAVL4 Proteine) and ELAVL1 (zeige ELAVL1 Proteine) control SynGAP (zeige SYNGAP1 Proteine) mRNA stability in a 3'UTR length-dependent manner, resulting in the stable expression of the alternatively spliced SynGAP (zeige SYNGAP1 Proteine) isoform alpha2.

  3. These two proteins were up-regulated in both HD and FUS/TLS heterozygote mice.

  4. Study established that Fus1 (zeige TUSC2 Proteine) KO mice suffer from the age-related hearing loss (ARHL) of strial origin, making this model a valuable tool for studying mitochondrial/oxidative mechanisms of age-related hearing decline. The model describes the phenotype of premature hearing loss of strial etiology based on Fus1 (zeige TUSC2 Proteine) loss-mediated mitochondrial dysfunction, and identify the target cells and tissues in the inner ear.

  5. Authors found that FUS, EWS (zeige EWSR1 Proteine) and TAF15 (zeige TAF15 Proteine) expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS and EWS (zeige EWSR1 Proteine) during neuronal differentiation.

  6. Study characterizes a heterozygous knock-in mouse model of ALS and demonstrates that mutations in FUS result in a toxic gain of function leading to motor neuron disease through cell autonomous and non-cell autonomous mechanisms; shows that mutant FUS triggers toxic events in both motor neurons and neighboring cells to elicit motor neuron disease.

  7. FUS-induced reductions to ER-mitochondria associations and are linked to activation of glycogen synthase kinase-3beta (GSK-3beta), a kinase already strongly associated with ALS/FTD (zeige FTL Proteine).

  8. our findings indicate that cytoplasmic FUS mislocalization not only leads to nuclear loss of function, but also triggers motor neuron death through a toxic gain of function within motor neurons.

  9. The data of this study support the notion that expression of cytoplasmically mislocalized FUS with compromised RNA-binding capacity causes particularly prominent and harmful FUS pathology in the mouse nervous system.

  10. These results highlight the pivotal role of FUS in regulating GluA1 (zeige GRIA1 Proteine) mRNA stability, post-synaptic function and fronto-temporal lobar degeneration-like animal behaviors.

FUS Protein Überblick

Protein Überblick

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.

Genbezeichner und Symbole assoziert mit Fused in Sarcoma Proteine (FUS)

  • FUS RNA binding protein (FUS)
  • fused in sarcoma (Fus)
  • FUS RNA binding protein (Fus)
  • fused in sarcoma (FUS)
  • ALS6 Protein
  • D430004D17Rik Protein
  • D930039C12Rik Protein
  • ETM4 Protein
  • FUS/TLS Protein
  • Fus1 Protein
  • HNRNPP2 Protein
  • POMP75 Protein
  • Tls Protein

Bezeichner auf Proteinebene für Fused in Sarcoma Proteine (FUS)

75 kDa DNA-pairing protein , RNA-binding protein FUS , fus-like protein , fusion gene in myxoid liposarcoma , heterogeneous nuclear ribonucleoprotein P2 , oncogene FUS , oncogene TLS , translocated in liposarcoma protein , fusion, derived from t(12;16) malignant liposarcoma , hnRNP P2 , pigpen protein , protein pigpen , translocated in liposarcoma , fusion , pigpen , fusion (involved in t(12;16) in malignant liposarcoma) , 16) in malignant liposarcoma) , 16) malignant liposarcoma , fusion (involved in t(12 , fusion, derived from t(12

GENE ID SPEZIES
2521 Homo sapiens
233908 Mus musculus
414144 Gallus gallus
280796 Bos taurus
317385 Rattus norvegicus
479778 Canis lupus familiaris
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