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The protein encoded by DUSP5 is a member of the dual specificity protein phosphatase subfamily. Zusätzlich bieten wir Ihnen DUSP5 Antikörper (58) und DUSP5 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Dusp-5 and Snrk-1 control an (zeige SNRK ELISA Kits)gioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1
Findings indicate that zinc-finger protein X-linked (ZFX (zeige ZFX ELISA Kits)) promotes colorectal cancer (CRC (zeige CALR ELISA Kits)) progression by suppressing dual specificity phosphatase 5 (DUSP5) expression and suggest that ZFX (zeige ZFX ELISA Kits) is a prognostic biomarker and potentially useful therapeutic target in stage II/III CRC (zeige CALR ELISA Kits) patients.
Results show that DUSP5 and DUSP6 (zeige DUSP6 ELISA Kits) mRNA are overexpressed in human PTCs, especially in BRAFV600E mutated papillary thyroid carcinomas (PTCs), and positively control cell migration and invasion.
role of the secondary binding site in assembling the DUSP5-pERK (zeige EIF2AK3 ELISA Kits) pre-reactive complex was further demonstrated by molecular dynamics simulations that showed that the remote C197-C219 disulfide linkage controls the structure of the secondary binding pocket based on its redox state (i.e., disulfide/dithiol) and, in turn, the enzymatic activity of DUSP5
The DUSP5 S147P protein is hypoactive compared to the DUSP5 wild-type protein.
Data indicate that cells from Burkitt's lymphoma, leukemia, neuroblastoma (zeige ARHGEF16 ELISA Kits) and Ewing sarcoma showed a higher dual-specificity phosphatase 5 pseudogene 1 (DUSP5P1)/dual specificity phosphatase 5 (DUSP5 ratio than normal cells.
DUSP1 (zeige DUSP1 ELISA Kits), DUSP4 (zeige DUSP4 ELISA Kits), and DUSP5 differentially modulate endothelial MAPK (zeige MAPK1 ELISA Kits) signaling pathways downstream of Tie-2 (zeige TEK ELISA Kits) receptors.
DUSP5 methylation may serve as a prognostic marker for gastric cancer (GC), but this requires validation in a larger set of GC samples.
Studies indicate that dual-specificity MAP kinase (zeige MAPK1 ELISA Kits) phosphatases (MKPs) DUSP6/MKP-3 (zeige DUSP6 ELISA Kits) and DUSP5 are localized in the cytoplasm and nuclear compartments.
DUSP5 and DUSP6 (zeige DUSP6 ELISA Kits) selectively control ERK (zeige EPHB2 ELISA Kits) pathway activity and proliferation.
the differential up-regulation of MKP3 (zeige DUSP6 ELISA Kits) by Ets2 (zeige ETS2 ELISA Kits) and of DUSP5 by c-Jun (zeige JUN ELISA Kits) may converge in similar functional roles for these MAP kinase (zeige MAPK1 ELISA Kits) phosphatases in the growth arrest versus proliferation decisions of breast cancer cells
This study shown that the Dusp15 promoter is sufficient for oligodendroglial expression and jointly activated by Sox10 and Myrf in an oligodendroglial cell line.
Dual specificity phosphatase 5 knockout (Dusp5-/- ) T cells display increased proliferation, increased apoptosis, and altered metabolic profiles, suggesting that DUSP5 is a pro-survival protein in T cells.
DUSP5 phosphatase is regulated at the transcriptional level by the MAPK (zeige MAPK1 ELISA Kits) pathway and that serum responsive element is involved in the regulation of this early response gene.
results suggest an in vivo role for DUSP5 as a tumor suppressor by modulating the oncogenic potential of activated Ras in the epidermis
After SSH between cDNA libraries from FD-Fms (zeige CSF1R ELISA Kits) cells stimulated by M-CSF (zeige CSF1R ELISA Kits) in the presence or the absence of U0126, we isolated DUSP5. DUSP5 expression is induced by M-CSF (zeige CSF1R ELISA Kits) in various myeloid cells & acts as a specific negative-feedback regulator of ERK1/2 (zeige MAPK1/3 ELISA Kits).
proper regulation of DUSP5 activity is critical for normal immune system development, IL-2 (zeige IL2 ELISA Kits) actions, and tolerance
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.
dual specificity protein phosphatase 5-like
, dual specificity phosphatase 5
, dual specificity protein phosphatase 5
, VH1-like phosphatase 3
, dual specificity protein phosphatase hVH3
, serine/threonine specific protein phosphatase
, MAP-kinase phosphatase (cpg21)
, MAP-kinase phosphatase CPG21
, candidate plasticity-related gene 21