anti-Cholinergic Receptor, Nicotinic, alpha 5 (Neuronal) (CHRNA5) Antikörper

The protein encoded by CHRNA5 is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Zusätzlich bieten wir Ihnen CHRNA5 Proteine (6) und CHRNA5 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CHRNA5 1138 P30532
CHRNA5 25102  
CHRNA5 110835 Q2MKA5
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Top anti-CHRNA5 Antikörper auf antikoerper-online.de

Showing 10 out of 88 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of CHRNA5 using anti-CHRNA5 antibody .   Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.    Lane 1: rat skeletal muscle tissue lysates,  Lane 2: HEPG2 whole cell lysates.   After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-CHRNA5 antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for CHRNA5 at approximately 53KD. The expected band size for CHRNA5 is at 53KD. IHC analysis of CHRNA5 using anti-CHRNA5 antibody .  CHRNA5 was detected in paraffin-embedded section of mouse intestine tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-FBXL4 Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-CHRNA5 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Spleen 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-CHRNA5 Antibody Titration:  1.0ug/ml  ELISA Titer:  1:12500  Positive Control:  Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$249.00
Details
Human Ziege Unkonjugiert ELISA, IHC, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.62
Details
Huhn Kaninchen Unkonjugiert WB Western blot analysis of CHRNA5 expression in HeLa (A), Jurkat (B), mouse brain (C), rat brain (D) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert WB CHRNA5 Antibody (Center)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CHRNA5 antibody detected the CHRNA5 protein (arrow). CHRNA5 Antibody (Center)  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the CHRNA5 antibody detected the CHRNA5 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Ziege Unkonjugiert ELISA, IHC, IHC (p), WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details

Weitere Antikörper gegen CHRNA5 Interaktionspartner

Human Cholinergic Receptor, Nicotinic, alpha 5 (Neuronal) (CHRNA5) Interaktionspartner

  1. Frequency of the cholinergic receptor nicotinic alpha 5 (CHRNA5) rs16969968-A allele and cholinergic receptor nicotinic alpha 3 (CHRNA3) rs1051730-T allele were significantly higher in lung cancer than in normal controls.

  2. The rs13180 (IREB2 (zeige IREB2 Antikörper)), rs16969968 (CHRNA5) and rs1051730 (CHRNA3 (zeige CHRNA3 Antikörper)) were significantly associated with Chronic obstructive pulmonary disease (COPD (zeige ARCN1 Antikörper)) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD (zeige ARCN1 Antikörper) in our population (Padj =0.0005, OR=0.61).

  3. Our present study suggested that rs667282 in CHRNA5-A3 may modify the prognosis of patients with advanced non-small cell lung cancer

  4. our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.

  5. The minor allele increased the risk of COPD (zeige ARCN1 Antikörper) when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD (zeige ARCN1 Antikörper) patients and with the number of pack-years among the male smokers.

  6. The data replicate previous result suggesting CHRNA5 as a candidate gene for chronic obstructive pulmonary disease (COPD (zeige ARCN1 Antikörper)) and rs8040868 as a risk variant for the development of COPD (zeige ARCN1 Antikörper) in the Swedish population.

  7. The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.

  8. Polymorphisms in the CHRNA5 and NRXN1 (zeige NRXN1 Antikörper) genes, influenced greater consumption of cigarettes in a Mexican Mestizo population.

  9. RP11 (zeige PRPF31 Antikörper)-650L12.2 rs149941240 polymorphism was associated with the risk of colorectal cancer.

  10. We determined that the other patients harbored mutations in genes that have not previously been linked to RTT or other neurodevelopmental syndromes, such as the ankyrin repeat containing protein ANKRD31 or the neuronal acetylcholine receptor subunit alpha-5 (CHRNA5).

Mouse (Murine) Cholinergic Receptor, Nicotinic, alpha 5 (Neuronal) (CHRNA5) Interaktionspartner

  1. The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine.

  2. Genetic deletion of alpha5 nAChR (zeige CHRNA4 Antikörper) subunits leads to a behavioural phenotype that exactly matches that observed after antagonizing dopamine receptors.

  3. Chrna5 KO mice did not exhibit high responses to novelty but showed decreased novelty-induced rearing behaviour together with high anxiety. Exposure to high doses of nicotine rescued these phenotypes. Results suggest that altered alpha5*-nAChR (zeige CHRNA4 Antikörper) cholinergic signalling contributes to emotional/behavioural impairments that may be alleviated by nicotine consumption.

  4. These results highlight the involvement of the alpha5 nAChR (zeige CHRNA4 Antikörper) subunit in the development of hyperalgesia, allodynia and inflammation associated with chronic neuropathic and inflammatory pain models.

  5. Overexpression of the genomic cluster CHRNA5/A3/B4 in mice increases somatic signs associated with morphine withdrawal and Knockout of alpha5 gene reduced somatic signs in morphine-treated mice

  6. Data reveal a highly regulated temporal-spatial pattern of alpha5 nAChR (zeige CHRNA4 Antikörper) subunit expression during important periods of lung morphogenesis by FoxA2 (zeige FOXA2 Antikörper).

  7. increased nicotine intake in mice with a null mutation in Chrna5

  8. Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.

CHRNA5 Antigen-Profil

Protein Überblick

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).

Genbezeichner und Symbole assoziert mit CHRNA5

  • cholinergic receptor, nicotinic, alpha 5 (chrna5) Antikörper
  • cholinergic receptor nicotinic alpha 5 subunit (CHRNA5) Antikörper
  • cholinergic receptor nicotinic alpha 5 subunit L homeolog (chrna5.L) Antikörper
  • cholinergic receptor nicotinic alpha 5 subunit (Chrna5) Antikörper
  • cholinergic receptor, nicotinic, alpha polypeptide 5 (Chrna5) Antikörper
  • Acra-5 Antikörper
  • Acra5 Antikörper
  • LNCR2 Antikörper
  • zgc:110642 Antikörper

Bezeichner auf Proteinebene für CHRNA5

neuronal acetylcholine receptor subunit alpha-5 , cholinergic receptor, nicotinic, alpha polypeptide 5 , Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5 , acetylcholine receptor, nicotinic, alpha 5 (neuronal) , neuronal nicotinic acetylcholine receptor, alpha5 subunit , acetylcholine receptor alpha 5 , cholinergic receptor neuronal nicotinic alpha protein 5 , nicotinic acetylcholine receptor alpha5 subunit

GENE ID SPEZIES
550584 Danio rerio
282177 Bos taurus
1138 Homo sapiens
446384 Xenopus laevis
386577 Gallus gallus
482112 Canis lupus familiaris
25102 Rattus norvegicus
619369 Pan troglodytes
110835 Mus musculus
Ausgewählte Anbieter für anti-CHRNA5 (CHRNA5) Antikörper
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