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The protein encoded by CHRNA5 is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Zusätzlich bieten wir Ihnen CHRNA5 Proteine (5) und CHRNA5 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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The rs13180 (IREB2 (zeige IREB2 Antikörper)), rs16969968 (CHRNA5) and rs1051730 (CHRNA3 (zeige CHRNA3 Antikörper)) were significantly associated with Chronic obstructive pulmonary disease (COPD (zeige ARCN1 Antikörper)) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD (zeige ARCN1 Antikörper) in our population (Padj =0.0005, OR=0.61).
Our present study suggested that rs667282 in CHRNA5-A3 may modify the prognosis of patients with advanced non-small cell lung cancer
our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.
The minor allele increased the risk of COPD (zeige ARCN1 Antikörper) when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD (zeige ARCN1 Antikörper) patients and with the number of pack-years among the male smokers.
The data replicate previous result suggesting CHRNA5 as a candidate gene for chronic obstructive pulmonary disease (COPD (zeige ARCN1 Antikörper)) and rs8040868 as a risk variant for the development of COPD (zeige ARCN1 Antikörper) in the Swedish population.
The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.
Polymorphisms in the CHRNA5 and NRXN1 (zeige NRXN1 Antikörper) genes, influenced greater consumption of cigarettes in a Mexican Mestizo population.
RP11 (zeige PRPF31 Antikörper)-650L12.2 rs149941240 polymorphism was associated with the risk of colorectal cancer.
We determined that the other patients harbored mutations in genes that have not previously been linked to RTT or other neurodevelopmental syndromes, such as the ankyrin repeat containing protein (zeige EHMT2 Antikörper) ANKRD31 or the neuronal acetylcholine receptor subunit alpha-5 (CHRNA5).
quitting smoking is highly beneficial in reducing lung cancer risks for smokers regardless of their CHRNA5 rs16969968 genetic risk status. Smokers with high-risk CHRNA5 genotypes, on average, can largely eliminate their elevated genetic risk for lung cancer by quitting smoking- cutting their risk of lung cancer in half and delaying its onset by 7years for those who develop it.
The findings reveal a proaddiction adaptive response to chronic nicotine in which nitric oxide and SST (zeige SST Antikörper) are released by a specific CHRNA5-expressing neuronal population to provide retrograde inhibition of the habenula- interpeduncular nucleus circuit and thereby enhance the motivational properties of nicotine.
Genetic deletion of alpha5 nAChR (zeige CHRNA4 Antikörper) subunits leads to a behavioural phenotype that exactly matches that observed after antagonizing dopamine receptors.
Chrna5 KO mice did not exhibit high responses to novelty but showed decreased novelty-induced rearing behaviour together with high anxiety. Exposure to high doses of nicotine rescued these phenotypes. Results suggest that altered alpha5*-nAChR (zeige CHRNA4 Antikörper) cholinergic signalling contributes to emotional/behavioural impairments that may be alleviated by nicotine consumption.
These results highlight the involvement of the alpha5 nAChR (zeige CHRNA4 Antikörper) subunit in the development of hyperalgesia, allodynia and inflammation associated with chronic neuropathic and inflammatory pain models.
Overexpression of the genomic cluster CHRNA5/A3/B4 in mice increases somatic signs associated with morphine withdrawal and Knockout of alpha5 gene reduced somatic signs in morphine-treated mice
Data reveal a highly regulated temporal-spatial pattern of alpha5 nAChR (zeige CHRNA4 Antikörper) subunit expression during important periods of lung morphogenesis by FoxA2 (zeige FOXA2 Antikörper).
increased nicotine intake in mice with a null mutation in Chrna5
Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
neuronal acetylcholine receptor subunit alpha-5
, cholinergic receptor, nicotinic, alpha polypeptide 5
, Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5
, acetylcholine receptor, nicotinic, alpha 5 (neuronal)
, neuronal nicotinic acetylcholine receptor, alpha5 subunit
, acetylcholine receptor alpha 5
, cholinergic receptor neuronal nicotinic alpha protein 5
, nicotinic acetylcholine receptor alpha5 subunit