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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Zusätzlich bieten wir Ihnen CLIC1 Proteine (12) und CLIC1 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CLIC1 Primary Antibody für WB - ABIN1881210
Valenzuela, Martin, Por, Robbins, Warton, Bootcov, Schofield, Campbell, Breit: Molecular cloning and expression of a chloride ion channel of cell nuclei. in The Journal of biological chemistry 1997
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Human Monoclonal CLIC1 Primary Antibody für IF, IHC (p) - ABIN560404
Megger, Bracht, Kohl, Ahrens, Naboulsi, Weber, Hoffmann, Stephan, Kuhlmann, Eisenacher, Schlaak, Baba, Meyer, Sitek: Proteomic differences between hepatocellular carcinoma and nontumorous liver tissue investigated by a combined gel-based and label-free quantitative proteomics study. in Molecular & cellular proteomics : MCP 2013
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Cow (Bovine) Polyclonal CLIC1 Primary Antibody für IHC, WB - ABIN2776130
Novarino, Fabrizi, Tonini, Denti, Malchiodi-Albedi, Lauro, Sacchetti, Paradisi, Ferroni, Curmi, Breit, Mazzanti: Involvement of the intracellular ion channel CLIC1 in microglia-mediated beta-amyloid-induced neurotoxicity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
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Human Monoclonal CLIC1 Primary Antibody für IHC (p), ELISA - ABIN560405
Chaze, Meunier, Chambon, Jurie, Picard: Proteome dynamics during contractile and metabolic differentiation of bovine foetal muscle. in Animal : an international journal of animal bioscience 2012
CLIC1 is a possible tumor marker for ovarian cancer. Dendritic cells pulsed with MtHsp70 (zeige HSPA9 Antikörper)-CLIC1 can enhance antitumor immunity against ovarian cancer, providing a novel immune therapeutic strategy.
Either dysfunction or downregulation of CLIC1 can partially decrease the antineoplastic effects of metformin.
The expression of CLIC1 might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of pancreatic ductal adenocarcinomas.
Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth.
Results indicate that CLIC1 is an important contributor to tumor invasion, metastasis, and angiogenesis.
CLIC1 acts as a putative oncogene (zeige RAB1A Antikörper) in pancreatic cancer.
Data show that glutamate (zeige GRIN1 Antikörper) 85 and glutamate (zeige GRIN1 Antikörper) 228 are pH-sensor residues of chloride intracellular channel protein CLIC1 and contribute to the pH-response stability in different ways.
CLIC1 and CLIC4 (zeige CLIC4 Antikörper) are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review)
CLIC1 may be a potential sensitive and specific molecular biomarker for early diagnose for serous epithelial ovarian cancers metastasis.
It participates in migration and invasion of hepatocellular carcinoma by targeting maspin (zeige SERPINB5 Antikörper).
Results indicate CLICs (CLIC1, CLIC4 (zeige CLIC4 Antikörper) and CLIC5 (zeige CLIC5 Antikörper))-dependent chloride efflux as an essential and proximal upstream event for NLRP3 (zeige NLRP3 Antikörper) activation.
We conclude that the role of CLIC1 in macrophage superoxide production is to support redistribution of NADPH oxidase (zeige NOX1 Antikörper) to the plasma membrane, and not through major effects on ERM (zeige ETV5 Antikörper) cytoskeleton or by acting as a plasma membrane chloride channel (zeige CLCA1 Antikörper).
Data, including data from studies in primary cells from knockout mice, suggest Clic1 and Clic4 (zeige CLIC4 Antikörper) participate in signaling interleukin 1beta secretion and in activation of Nlrp3 (zeige NLRP3 Antikörper) inflammasomes; in LPS (zeige TLR4 Antikörper) macrophage activation, Clic1 and Clic4 (zeige CLIC4 Antikörper) are translocated to nucleus/cell membranes. (Clic1 = chloride intracellular channel 1; Clic4 (zeige CLIC4 Antikörper) = chloride intracellular channel 4 (zeige CLIC4 Antikörper), mitochondrial; Nlrp3 (zeige NLRP3 Antikörper) = NLR family pyrin domain containing 3 (zeige NLRP3 Antikörper))
This study demonstrates for the first time that CLIC1 is overexpressed during AS development both in vitro and in vivo and can regulate the accumulation of inflammatory cytokines and production of oxidative stress.
Clic1 have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 (zeige ANXA7 Antikörper) and Gelsolin (zeige GSN Antikörper).
These data all point to an important role for CLIC1 in regulating macrophage function through its ion channel activity.
The down-regulation of CLIC1 enhanced proliferative activity.
CLIC1 may play an important role in tumor metastasis.
CLIC1 is essential for the proliferation and invasion of hepatocellular carcinoma cells.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family\; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.
chloride intracellular channel 1
, RNCC protein
, chloride channel ABP
, chloride intracellular channel protein 1
, nuclear chloride ion channel 27
, nuclear chloride ion channel protein
, regulatory nuclear chloride ion channel protein