anti-Chemokine (C-C Motif) Receptor 1 (CCR1) Antikörper

Human Chemokine (C-C Motif) Receptor 1 (CCR1) Interaktionspartner

1. The polymorphism of CCR1 rs3733096 and CCL5 rs3817656 are associated with spontaneous clearance of hepatitis C virus in Chinese Han population.

2. Data suggest that CCR1 gene may be a putative marker of molecular activity of Crohn's disease.

3. Results reveal that CCR1 expression is positively correlated with OPN expression in hepatocellular carcinoma cells, and the patients with high levels of both OPN and CCR1 have the most dismal prognosis. Study also, shows that steopontin upregulates CCR1 in HCC cells and, that CCR1 is essential for osteopontin-induced HCC metastasis.

4. Expression of CCR1 was measured in retrospective clinical specimens of colorectal cancer lung metastases. CCR1+ cells accumulated around the CCL15-positive colorectal cancer cells in the lung, but few around the CCL15-negative ones.

5. during renal transplantation, CD4+ and CD8+ T cells expressing CCR1 were increased in patients who developed renal allograft dysfunction

6. MIP-1alpha receptor antagonism can significantly reduce T cell migration to the secreted factors from Oesophagogastric adenocarcinoma omentum and liver.

7. These data suggest that CCR1/CCR2B could be involved in clearing EBV-infected latency III B cells in immunocompetent individuals via directing the migration of these cells and attracting the chemokines-expressing immune cells.

8. Data suggest that the interplay between CCR1 upregulation and inactivation of CXCR4 signaling (the CCR1/CXCR4 axis) drives the egress of multiple myeloma PCs from the bone marrow, leading to disease dissemination.

9. Basophil migration into skin lesions of Systemic Lupus Erythematosus patients were observed, but not in normal skin tissue. This migration was related to the upregulation of chemokine receptors CCR1 and CCR2 on basophils.

10. Study indicates that two distinct micro-environmental factors, CD40L and Mphis, signal via CCR1 to induce AKT activation resulting in translational stabilization of MCL-1, and hence can contribute to CLL cell survival.

11. CCL15 activation of CCR1 plays critical roles in hepatocellular carcinoma metastasis.

12. CCL15-positive primary colorectal cancers recruited approximately 2.2 times more numbers of CCR1(+) cells.

13. The residues on the N-loop and beta-sheets of MIP-1a are close to both CCR1 and CCR5, and those in the C-terminal helix region are close to CCR5.

14. Results highlight the potential role of CCR genes in narcolepsy and support the hypothesis that patients with narcolepsy have impaired immune function.

15. CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 are bona fide susceptibility genes for Behcet's disease.

16. This study reveled that CCR1 having a central role in the bipolar disease and schizophrenia manifestation.

17. Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, beta-arrestin translocation and chemotaxis assays

18. These results suggest that increased CC-chemokine receptor expression may play a role in the pathogenesis of adenomyosis.

19. Our results confirm the strong influence of previous immunity in subsequent dengue infections, and confer a possible pathogenic role to CCR1 and CCL3 in dengue disease and a possible protective role for CCL5, probably through CCR5 interaction.

20. cross-desensitization of CCR1 by FPR1 was associated with CCR1 phosphorylation and moderate reduction of CCR1 cell-surface expression. In contrast, CCR2 was not phosphorylated or internalized after FPR1 activation.

Mouse (Murine) Chemokine (C-C Motif) Receptor 1 (CCR1) Interaktionspartner

1. CCL9 secreted by splenic macrophages induces a CCR1dependent accumulation of MDSCs.

2. The enhanced presence of CCL3 can explain the immediate analgesic effects, independent from an anti-inflammatory action, evoked by the administration of the CCR1 antagonist J113863 in carrageenan- and complete Freund's adjuvant inflamed mice.

3. Inhibition of CCR1, the distal part of this signaling relay, may have a therapeutic impact in metastatic disease with lower toxicity than blocking upstream targets.

4. Data indicate that deletion or inhibition of CC chemokine receptor 1 (CCR1) decreases pain responses.

5. CCR1-mediated accumulation of myeloid cells in the liver microenvironment promotes mouse colon cancer metastasis.

6. CCR1 is required for recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara.

7. This study demonstrates a Tpl2-dependent mechanism for macrophage expression of select chemokine receptors.

8. Ccr1 plays a critical role in the recruitment of T and mononuclear phagocyte cells to inflamed kidneys of NZB/W mice, which in turn contribute to the progression of renal injury.

9. CCR1.beta-arrestin-2 complex may be related to a potential scavenging function of the receptor, which may be important for maintenance of chemokine gradients and receptor responsiveness in complex fields of chemokines during inflammation.

10. CCR1 expression by both hematopoietic and nonhematopoietic cells favors tumor aggressiveness and liver cancer metastasis development.

11. findings show that CCR1 is pivotal for bone remodeling induced by mechanical loading during orthodontic tooth movement and these actions depend, at least in part, on CCL3

12. neutrophil Ccr1 amplifies late renal immunopathology and increases mortality in invasive candidiasis by mediating excessive recruitment of neutrophils from the blood to the target organ.

13. a bis-quinoline compound, (7-chloro-N-(4-(7-chloroquinolin-4-ylamino)butyl)quinolin-4-amine; RE-660) has C-C chemokine receptor type 1 (CCR1)-agonistic properties

14. CCR1 functions within the glioblastoma microenvironment through CCR1 and CCR5 in a redundant manner.

15. The selective interaction of CCL3 with its receptor, CCR1, is critical for radiation-induced lung inflammation and fibrosis, and these conditions can be largely prevented by a small molecule inhibitor of CCR1

16. chemokine receptors CCR1, CCR2 and CCR4 have roles in the pathogenesis of experimental dengue infection in mice

17. Data suggest that the CCR1 receptor has a key role in the pathogenesis of smoke-induced inflammation.

18. These results suggest that peripheral nerve injury elicits the up-regulation of spinal MIP-1alpha and CCR1 to participate in neuropathic pain.

19. the axis of CCR1 and its ligands are likely to be involved in cross-talk between osteoclasts and osteoblasts by modulating the RANK-RANKL-mediated interaction.

20. Lack of the Ccr1, Mmp2, or Mmp9 gene in the host dramatically suppresses outgrowths of disseminated tumors in the liver.