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anti-Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Antikörper

CABLES1 encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human CABLES1 CABLES1 91768 Q8TDN4
Anti-Maus CABLES1 CABLES1 63955 Q9ESJ1
Anti-Ratte CABLES1 CABLES1 307585  
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Top anti-Cdk5 and Abl Enzyme Substrate 1 Antikörper auf antikoerper-online.de

Showing 10 out of 37 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-CABLES1 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IC, IF, IHC, WB Immunofluorescent analysis of CABLES1 staining in SHSY5Y cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of CABLES1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from LOVO cells, using Ik3-1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IHC, WB Western Blot: CABLES1 Antibody [ABIN4083003] - Western blot (WB) analysis of CABLES1 (K588) antibody in extracts from LOVO cells. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$490.19
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Huhn Kaninchen Unkonjugiert WB   50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Rind (Kuh) Kaninchen Unkonjugiert WB   50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details

Weitere Antikörper gegen Cdk5 and Abl Enzyme Substrate 1 Interaktionspartner

Zebrafish Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. cables1 is important for neural differentiation during embryogenesis, in a mechanism that likely involves interactions with the Cdk5 (zeige CDK5 Antikörper)/p35 (zeige CDK5R1 Antikörper) kinase pathway.

Human Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. We have identified four potentially pathogenic missense CABLES1 variants as a novel, although infrequent, cause of Cushing's Disease in children and young adults.

  2. miR199a-3p and P53 (zeige TP53 Antikörper) are coupled through CABLES1 and comprise a novel negative feedback loop that likely contributes to cardiac c-kit (zeige KIT Antikörper)(+) cell proliferation and apoptosis.

  3. Cables1/p21 (zeige CDKN1A Antikörper) pathway has a strong effect on the induction of cell senescence and inhibition of cell growth, and acts as a novel regulatory mechanism in which p21 (zeige CDKN1A Antikörper) is probably one of several downstream effector molecules to mediate Cables1.

  4. CABLES1 is a critical regulator of corticotrope proliferation that defines a pathway often inactivated in Cushing disease

  5. the results suggest Cables1 as a novel p21 (zeige CDKN1A Antikörper) regulator through maintaining p21 (zeige CDKN1A Antikörper) stability and support the model that the tumor-suppressive function of Cables1 occurs at least in part through enhancing the tumor-suppressive activity of p21 (zeige CDKN1A Antikörper).

  6. Results illuminated a dynamic regulatory system through which activated Akt (zeige AKT1 Antikörper) and 14-3-3 (zeige YWHAQ Antikörper) work directly together to neutralize a potent tumor suppressor function of Cables1.

  7. The results did not detect a significant association. It indicated that common genetic variations in CDK5 (zeige CDK5 Antikörper) genes might not play a role in the genetic predisposition to autism.

  8. Analysis of the RT-PCR prducts of the CABLES1 gene showed eight intragenic deletions in its mRNA transcripts; 5/8 are the result of RNA splicing.

  9. Mechanisms of CABLES1 gene inactivation in ovarian cancer development are reported.

Mouse (Murine) Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Interaktionspartner

  1. Loss of Cables1 enhances tumor progression in the Apc (zeige APC Antikörper)(Min/+) mouse model and activates the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model.

  2. Agenesis of the corpus callosum frequency in Cables1(+/TAS (zeige MAP3K4 Antikörper)) mice was significantly lower than that in Cables1(-/TAS (zeige MAP3K4 Antikörper)) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS (zeige MAP3K4 Antikörper)).

  3. Data show that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress.

  4. Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood.

Cdk5 and Abl Enzyme Substrate 1 (CABLES1) Antigen-Profil

Protein Überblick

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit CABLES1

  • Cdk5 and Abl enzyme substrate 1 (CABLES1) Antikörper
  • Cdk5 and Abl enzyme substrate 1 (cables1) Antikörper
  • Cdk5 and Abl enzyme substrate 1 (CpipJ_CPIJ019832) Antikörper
  • CDK5 and Abl enzyme substrate 1 (Cables1) Antikörper
  • Cdk5 and Abl enzyme substrate 1 (Cables1) Antikörper
  • CABL1 Antikörper
  • Cables Antikörper
  • CABLES1 Antikörper
  • HsT2563 Antikörper
  • ik3-1 Antikörper
  • si:dkey-2p18.3 Antikörper

Bezeichner auf Proteinebene für CABLES1

Cdk5 and Abl enzyme substrate 1 , CDK5 and ABL1 enzyme substrate 1 , CDK5 and ABL1 enzyme substrate 1-like , interactor with CDK3 1 , cdk3-binding protein ik3-1 , interactor-1 with cdk3

GENE ID SPEZIES
455335 Pan troglodytes
100059359 Equus caballus
100126070 Danio rerio
100345850 Oryctolagus cuniculus
100479459 Ailuropoda melanoleuca
6054063 Culex quinquefasciatus
100562423 Anolis carolinensis
100603520 Nomascus leucogenys
91768 Homo sapiens
63955 Mus musculus
768914 Gallus gallus
100682687 Canis lupus familiaris
100526114 Sus scrofa
100138286 Bos taurus
307585 Rattus norvegicus
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