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May be involved in formation of stretch-resistant cell- cell adhesion complexes (By similarity)..
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Monoclonal CTNNA3 Primary Antibody für ICC, FACS - ABIN335388
Janssens, Goossens, Staes, Gilbert, van Hengel, Colpaert, Bruyneel, Mareel, van Roy: alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. in Journal of cell science 2001
alpha-catenins regulate intercalated disc maturation and actomyosin contractility, which, in turn, control Yap (zeige YAP1 Antikörper) subcellular localization, thus providing an explanation for the loss of proliferative capacity in the newborn mammalian heart.
AlphaT-catenin may contribute to asthma through a mechanism independent of inflammation and related to heart and pulmonary vein dysfunction.
alphaT-catenin-null mice are viable and fertile; however, the animals exhibit progressive cardiomyopathy
study suggests a pivotal role of alphaT-catenin levels in the control of the proliferative versus invasive state of trophoblasts during placentation
By providing an extra link between the cadherin-catenin complex and intermediate filaments, the binding of alphaT-catenin to plakophilin-2 (zeige PKP2 Antikörper) is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells.
Double MYH7 (zeige MYH7 Antikörper) CTTNA3 heterozygotes showed a variable clinical expression of arrhythmogenic cardiomyopathy and hypertrophic cardiomyopathy. One carrier of double mutations in CTTNA3 and MYH7 (zeige MYH7 Antikörper) genes did not fulfill the current diagnostic criteria for cardiomyopathy.
The functional investigations might indicate involvement of alpha-T-catenin/CTNNA3 in the biology of peripheral nerve sheath tumors.
CTNNA3 association with essential tremor.
We conducted a meta-analysis of studies involving CHAT, TFAM (zeige TFAM Antikörper), and VR22 polymorphisms and Alzheimer disease susceptibility. For TFAM (zeige TFAM Antikörper) and VR22, no significant association was detected in studied single-nucleotide polymorphisms (SNPs). Rs10997691 and rs7070570 of VR22 are not significantly associated with AD risk.
Loss of CTNNA3 expression is associated with hepatocellular carcinoma.
Among the genes replicated across the two samples (permutated p < 0.05 in both of them), CTNNA3 appeared promising. The inorganic cation transmembrane transporter activity pathway (GO:0022890) was associated with antidepressant response in both samples (p = 2.9e-5 and p = 0.001 in the Korean and STAR*D samples, respectively)
Two African-ancestry specific variants were found to be significantly associated with metabolic syndrome S: SNP rs73989312[A] near CA10 (zeige CA10 Antikörper) that conferred increased risk; and SNP rs77244975[C] in CTNNA3 that conferred protection against this disease.
CTNNA3 and SEMA3D (zeige SEMA3D Antikörper): Promising loci for asthma exacerbation identified through multiple genome-wide association studies
This study demonstrated that the copy number variations of CTNNA3 relate to opioid dependence.
Copy Number Variations in CTNNA3 and RBFOX1 (zeige A2BP1 Antikörper) Associate with Pediatric Food Allergy
May be involved in formation of stretch-resistant cell- cell adhesion complexes (By similarity).
catenin, alpha 3
, catenin alpha-3
, catenin (cadherin-associated protein), alpha 3
, alpha T-catenin
, alpha-catenin-like protein
, cadherin-associated protein
, catenin alpha 3