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The protein encoded by CAST is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. Zusätzlich bieten wir Ihnen Calpastatin Kits (18) und Calpastatin Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 86 products:
Human Polyclonal Calpastatin Primary Antibody für FACS, IF (p) - ABIN720161
Huang, Rose, Hoffmann, Hashimoto, Bertino, Denk, Takano, Iwata, Saido, Hoffmann: Calpastatin prevents NF-?B-mediated hyperactivation of macrophages and attenuates colitis. in Journal of immunology (Baltimore, Md. : 1950) 2013
Cow (Bovine) Monoclonal Calpastatin Primary Antibody für ICC, IF - ABIN267335
Kaur, Mencl, Sahaboglu, Farinelli, van Veen, Zrenner, Ekström, Paquet-Durand, Arango-Gonzalez: Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats. in PLoS ONE 2011
Cow (Bovine) Monoclonal Calpastatin Primary Antibody für ICC, WB - ABIN283976
Zór, Castellarnau, Pascual, Pich, Plasencia, Bardsley, Nistor: Design, development and application of a bioelectrochemical detection system for meat tenderness prediction. in Biosensors & bioelectronics 2011
single nucleotide polymorphisms in CAST gene confer risk for keratoconus susceptibility in Han Chinese population
Kaposi sarcoma-associated herpesvirus reduces CAST (calpastatin) and consequently decreases ATG5 (zeige ATG5 Antikörper) expression in both THP-1 (zeige GLI2 Antikörper) monocytoid cells and primary monocytes.
calpains and calpastatin in patients with idiopathic pulmonary arterial hypertension (PAH) and mice with hypoxic or spontaneous (SM22 (zeige TAGLN Antikörper)-5HTT (zeige SLC6A4 Antikörper)(+) strain) PH, were investigated.
Loss of CAST in angiogenic ECs facilitates mu (zeige JAK3 Antikörper)-calp (zeige STAT1 Antikörper)ain-induced SOCS3 degradati (zeige SOCS3 Antikörper)on, which amplifies p (zeige VEGFC Antikörper)athological angiogenesis through interleukin-6/STAT3/VEGF-C axis.
We describe PLACK syndrome, as a clinical entity of defective epidermal adhesion, caused by loss-of-function mutations in calpastatin.
Calpastatin binds with Cav1.2 (zeige CACNA1C Antikörper) amino acid motifs in a calcium dependent manner.
Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson's disease in the Han Chinese population.
HER2 (zeige ERBB2 Antikörper) inhibited calpain-1 (zeige CAPN1 Antikörper) activity through upregulating calpastatin, an endogenous calpain inhibitor.
The results suggest that calpain-2 (zeige CAPN2 Antikörper) and calpastatin expression is important in pancreatic cancers, influencing disease progression
Neuronal overexpression of calpastatin modulates amyloid precursor protein (zeige APP Antikörper) processing in brains of transgenic beta-amyloid depositing mice.
Defective scar formation after myocardial infarction in calpastatin transgenic mice was associated with blunted CD4 (zeige CD4 Antikörper)(+) T-cell and M2-macrophage recruitment.
Over-expression of Cast inhibits calpain activation and attenuates post-infarction myocardial remodeling.
EC-specific transgenic CAST downregulated JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) signals, upregulated SOCS3 (zeige SOCS3 Antikörper), and depleted VEGF-C (zeige VEGFC Antikörper), counteracting unstable pathological neovessels and disease progression in tumors and oxygen-induced retinopathy lesions in mice.
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-synuclein processing, aggregation and synaptic impairment in transgenic mice.
We observed that ischemia induction results in increased expression of CaN, Calp (zeige KCNIP4 Antikörper) and Calpn.
Over-expression of calpastatin enhances doxorubicin-induced cardiac injuries through calpain inhibition.
The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.
Data show that genetic deficiency of calpastatin (CS) augmented Abeta (zeige APP Antikörper) amyloidosis, tau phosphorylation, microgliosis, and somatodendritic dystrophy, and increased mortality in amyloid precursor protein (APP (zeige APP Antikörper)) transgenic mice.
PIN1 apparently restrains the ability of calpastatin to inhibit calpain, maintaining calpain activity in endothelial cells.
The calpastatin gene (CAST), which is located on bovine chromosome 7 (BTAU7), is considered a strong functional candidate for meat tenderness in livestock species.
The suppression of calpastatin resulted in the increased expression of mu-calpain (zeige CAPNL1 Antikörper), caspases, and HSPs which in turn regulate apoptotic cell death.
This work is supportive of the importance of CAPN1 (zeige CAPNL1 Antikörper) and CAST for mean tenderness in beef.
bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1 (zeige CAPNL1 Antikörper)/CAST4 complex structures
CAST binds and inhibits CAPN via its CAPN-inhibitor domains(CAST1 (zeige ERC2 Antikörper)-4) .CAST4 docks near the flexible active site of CAPN1 (zeige CAPNL1 Antikörper), conformational changes at the interaction site after binding could be directly related to CAST4 inhibitory activity.
This work confirms the importance of CAPN1 (zeige CAPNL1 Antikörper) and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR (zeige GHR Antikörper) as a selection marker for beef quality.
The association of single nucleotide polymorphisms in calpastatin with muscle tenderness was studied.
Association of polymorphisms in calpain 1 (zeige CAPN1 Antikörper), (mu/I) large subunit, calpastatin, and cathepsin D (zeige CTSD Antikörper) genes with meat quality traits in double-muscled Piemontese cattle.
The CAST28 genotypes showing allele frequencies of C (0.429) and T (0.571) were significantly associated with calpastatin activity and Warner-Bratzler Shear Force in beef.
The association of polymorphisms in calpastatin and mu-calpain (zeige CAPNL1 Antikörper) genes with meat tenderness in 3 French beef breeds is reported.
CT1 (zeige SLC6A8 Antikörper) decreases cell death through a mechanism related to Stat3 (zeige STAT3 Antikörper) and Akt (zeige AKT1 Antikörper) phosphorylation and activation of calpastatin in D-galactosamine-treated hepatocytes.
CAST gene affected post-mortem activation time of calpain and drip loss.
The quality of meat influenced by RYR1 (zeige RYR1 Antikörper) genotype may be modified by the simultaneous influence of genotype as regards the CAST locus
The effect of the beta-adrenergic agonist clenbuterol and porcine ST (pST (zeige SULT1A1 Antikörper)) treatment on calpastatin promoter usage in vivo and in vitro are reported.
The Decreased expression of calpastatin mRNA during development is highly correlated with muscle protein accumulation in neonatal Sus scrofa.
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
, sperm BS-17 component
, calpastatin type III
, calpastatin isoform III
, calpastatin type I
, calpastatin type II