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CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites.
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Human Polyclonal CTCFL Primary Antibody für ICC, IF - ABIN4285064
Hines, Bazarov, Mukhopadhyay, Yaswen: BORIS (CTCFL) is not expressed in most human breast cell lines and high grade breast carcinomas. in PLoS ONE 2010
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Human Polyclonal CTCFL Primary Antibody für ELISA, WB - ABIN151496
Klenova, Morse, Ohlsson, Lobanenkov: The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. in Seminars in cancer biology 2002
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Human Polyclonal CTCFL Primary Antibody für ELISA, WB - ABIN129668
Dougherty, Ichim, Liu, Reznik, Min, Ghochikyan, Agadjanyan, Reznik: Selective apoptosis of breast cancer cells by siRNA targeting of BORIS. in Biochemical and biophysical research communications 2008
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Human Polyclonal CTCFL Primary Antibody für WB - ABIN2775057
Sun, Huang, Nguyen, Bisht, Bar-Sela, Ho, Bradbury, Yu, Cui, Lee, Trepel, Feinberg, Gius: DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. in Cancer research 2008
These findings highlight the role of intragenic DNA methylation (zeige HELLS Antikörper) and DNA binding protein (zeige UBE2V1 Antikörper) BORIS in cancer-specific splicing and its role in tumorigenesis.
The CCCTC-binding factor (zeige CTCF Antikörper) plays critical roles in genome topology and function, increased risk of carcinogenicity, and potential of lung cancer-specific mediations. Chromosome reposition in lung cancer can be regulated by CCCTC binding factor (zeige CTCF Antikörper)
These data provide information on the organization of the BORIS promoter region and gene regulation in normal and cancer cells. In addition, the study proposes that specific alleles of the BORIS-MS2 (zeige FAR2 Antikörper) region could be used to identify the risk for lung cancer.
the results indicate that the CT antigen BORIS sf6 is specifically expressed in cervical cancer stem-like cells and cancer-initiating cells
BORIS is associated with the cancer stem cell-like traits of human liver cancer cells through the epigenetic regulation of OCT4 (zeige POU5F1 Antikörper).
In this study, the methylation status of BORIS was tested by methylation specific polymerase chain reaction in human hepatocarcinoma (HCC (zeige FAM126A Antikörper)) cell lines and 43 pairs of tissue specimens. Frequently demethylation of BORIS in HCC (zeige FAM126A Antikörper) was significantly higher than that in the paired adjacent non-tumor tissues (P=0.019), and it was correlated with tumor size (P=0.025) and clinical TNM (zeige ODZ1 Antikörper) stage (P=0.035).
Effectively controlling BORIS/CTCFL levels can inhibit disease establishment and hence can be considered as a potent target for cancer therapy
BORIS is associated with cancer stem cell-enriched populations of several epithelial tumor cells and the different phenotypes depend on the origin of tumor cells.
Data found that BORIS and CTCF (zeige CTCF Antikörper) expression in low-grade squamous intraepithelial lesions and invasive cervical carcinoma is higher than in normal samples. The possible utility of BORIS and CTCF (zeige CTCF Antikörper) as biomarkers in cervical neoplasm requires further analysis.
In the first detailed analysis in cancer, a marked loss of CHD8 (zeige CHD8 Antikörper) expression and increased BORIS/CTCF (zeige CTCF Antikörper) ratio indicate frequent disruption of CTCF (zeige CTCF Antikörper) and its effector genes in PCa (zeige FLVCR1 Antikörper).
The TGFB (zeige TGFB1 Antikörper) pathway as most affected by embryonic Ctcfl expression.
down-regulation of endogenous BORIS by specific shRNAs inhibited both RNA transcription and cell cycle progression. The results altogether suggest a role for BORIS in coordinating S phase events with mitosis.
Rb2 (zeige RBL2 Antikörper) coimmunolocalizes with the chromatin insulator CCCTC-binding factor (CTCF (zeige CTCF Antikörper)) and BORIS in T-antigen-positive but not in T-antigen-negative cells.
These findings show that BORIS expression is more widespread than previously believed, and suggest a role for BORIS in nucleolar function.
findings indicate that BORIS-induced expression of TSP50 (zeige PRSS50 Antikörper) is governed by accessibility and binding of BORIS to the promoter
These findings define transcriptional regulation of CST (Gal3st1 (zeige GAL3ST1 Antikörper)) expression as a critical role for BORIS in spermatogenesis.
CTCFL and PRMT7 (zeige PRMT7 Antikörper) may play a role in male germline imprinted gene methylation.
CTCFL/BORIS is a methylation-independent DNA-binding protein (zeige HSF4 Antikörper) that preferentially binds to the paternal H19 (zeige NCKAP1 Antikörper) differentially methylated region
DNA damage-induced and ATR (zeige ATR Antikörper)/Rfx1 (zeige RFX1 Antikörper)-mediated increase of miR (zeige MLXIP Antikörper)-709 expression in exposed testes may be a protective mechanism that effectively decreases a cellular level of BORIS to prevent massive aberrant erasure of DNA methylation (zeige HELLS Antikörper) after radiation exposure.
CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, CTCF paralog
, CTCF-like protein
, brother of the regulator of imprinted sites
, cancer/testis antigen 27
, putative high mobility group protein 1-like 1
, putative high mobility group protein B1-like 1
, transcriptional repressor CTCFL
, zinc finger protein CTCF-T
, CCCTC-binding factor (zinc finger protein)-like
, CCCTC-binding factor-like protein
, Brother of the regulator of imprinted sites
, likely orthologue of H. sapiens CCCTC-binding factor-like protein (CTCFL)
, brother of regulator of imprinted sites
, transcriptional repressor CTCFL-like