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CLEC14A encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.
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Human Polyclonal CLEC14A Primary Antibody für CyTOF, FACS - ABIN4899675
Ki, Jeoung, Choi, Rho, Kwon, Shim, Chung, Hong, Song, Lee: Human antibodies targeting the C-type lectin-like domain of the tumor endothelial cell marker clec14a regulate angiogenic properties in vitro. in Oncogene 2013
Show all 3 Pubmed References
Human Polyclonal CLEC14A Primary Antibody für IHC, IHC (p) - ABIN4299111
Galvagni, Nardi, Spiga, Trezza, Tarticchio, Pellicani, Andreuzzi, Caldi, Toti, Tosi, Santucci, Iozzo, Mongiat, Orlandini: Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium. in Matrix biology : journal of the International Society for Matrix Biology 1970
Human Monoclonal CLEC14A Primary Antibody für FACS - ABIN4896507
Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. in Journal of leukocyte biology 2017
These findings identify novel protein interactions involving CLEC14A, CD93 (zeige CD93 Antikörper) and CD248 (zeige CD248 Antikörper) with MMRN2 (zeige MMRN2 Antikörper) as targetable components of vessel formation
The CLEC14A-MMRN2 (zeige MMRN2 Antikörper) interaction is involved in sprouting angiogenesis. Disrupting this interaction with monoclonal antibodies directed against CLEC14A show anti-angiogenic and anti-tumor effects.
CLEC14A is a matrix component which binds to MMRN2 (zeige MMRN2 Antikörper) in the process of endothelial cells transformation in tumor angiogenesis.
clec14a-CTLD may be a key domain in angiogenesis
In this study, they identify and characterize a novel tumor endothelial marker, CLEC14A, which has properties that suggest it is a candidate for tumor vascular targeting and anti-angiogenic approaches.
CLEC14A acts in vascular homeostasis by fine-tuning VEGFR-2 (zeige KDR Antikörper) and VEGFR-3 (zeige FLT4 Antikörper) signaling in endothelial cells
These findings demonstrate that Clec14a is a novel endothelial cells specific protein that appears to play a role in cell-cell adhesion and angiogenesis.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting.
C-type lectin domain family 14 member A
, ClECT and EGF-like domain containing protein
, epidermal growth factor receptor 5