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Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\; MIM 602894) and NKG2D (KLRC4\; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. Zusätzlich bieten wir Ihnen C-Type Lectin Domain Family 1, Member B Proteine (11) und C-Type Lectin Domain Family 1, Member B Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Monoclonal CLEC1B Primary Antibody für FACS, WB - ABIN2473003
de Lacey, McCabe, Constant, Welch, Spinks, McNally: Testing a policy for skull radiography (and admission) following mild head injury. in The British journal of radiology 1990
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Mouse (Murine) Monoclonal CLEC1B Primary Antibody für FACS - ABIN2473004
Kerrigan, Dennehy, Mourão-Sá, Faro-Trindade, Willment, Taylor, Eble, Reis e Sousa, Brown: CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. in Journal of immunology (Baltimore, Md. : 1950) 2009
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Mouse (Murine) Monoclonal CLEC1B Primary Antibody für FACS - ABIN2473005
Mourão-Sá, Robinson, Zelenay, Sancho, Chakravarty, Larsen, Plantinga, Van Rooijen, Soares, Lambrecht, Reis e Sousa: CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses. in European journal of immunology 2011
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Human Monoclonal CLEC1B Primary Antibody für IP, ELISA - ABIN526588
Manne, Badolia, Dangelmaier, Kunapuli: C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets. in Biochemical pharmacology 2015
Human Polyclonal CLEC1B Primary Antibody für ELISA, WB - ABIN408714
Suzuki-Inoue, Kato, Inoue, Kaneko, Mishima, Yatomi, Yamazaki, Narimatsu, Ozaki: Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. in The Journal of biological chemistry 2007
the CHIP/CLEC-2 axis may play an important role in the modulation of immune response.
Data (including data from studies using cells from knockout mice) suggest that CLEC2/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ (zeige GNAQ Antikörper) agonists. (CLEC2 = C-type lectin (zeige MBL2 Antikörper) CLEC2; CLEC2R = CLEC2 receptor; GNAQ (zeige GNAQ Antikörper) = guanine nucleotide-binding protein (zeige COASY Antikörper) G[q] subunit alpha)
NZ-1 inhibits the hPDPN-CLEC-2 interaction and is also useful for anti-PA tag MAb.The minimum epitope of LpMab-13 was identified as Ala42-Asp49 of hPDPN using Western blot and flow cytometry. The combination of different epitope-possessing MAbs could be advantageous for the hPDPN-targeting diagnosis and therapy
CLEC2 prevents expression of PI3K (zeige PIK3CA Antikörper) subunits, in a SYK (zeige SYK Antikörper)-dependent manner, to suppress the invasive activities of gastric cancer cells.
CLEC-2 regulates Akt and MAPK downstream of PI3K and PKC, leading to phosphorylation and inhibition of GSK3alpha/beta, and enhanced platelet aggregation and secretion.
Data (including data from studies using recombinant proteins) suggest that a diverse range of ligands activate platelets through activation/phosphorylation (zeige CD36 Antikörper) of C (zeige GP6 Antikörper)D36/GPVI (glycoprotein VI) and/or CLEC-2 (C-type lectin-like receptor-2).
PI3K (zeige PIK3CA Antikörper) and Tec (zeige NR4A3 Antikörper) family kinases play a crucial role in the regulation of platelet activation and Syk (zeige SYK Antikörper) phosphorylation downstream of the CLEC-2 receptor
fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway
Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the tyrosine kinase Syk via its tandem SH2 domains and initiation of a downstream signaling cascade
A differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation.
CLEC-2 deficiency may inhibit thrombus formation in tumor vessels and increase the density of functional vessels, thus improving oxygen and nutrient supply to tumors, indirectly promoting tumor proliferation
these data suggest that the platelet CLEC-2-podoplanin (zeige PDPN Antikörper) signaling axis regulates the severity of lung inflammation in mice and is a possible novel target for therapeutic intervention in patients at risk of developing ARDS.
a hemITAM signaling-independent role for CLEC-2 in hemostasis and thrombosis
a novel mechanism of Deep vein thrombosis, whereby CLEC-2 and upregulation of podoplanin (zeige PDPN Antikörper) expression in the venous wall trigger thrombus formation
A reciprocal interaction between CLEC-2 on megakaryocytes and PDPN (zeige PDPN Antikörper) on Bone marrow (BM) Fibroblastic reticular cell-like cells contributes to the periarteriolar megakaryopoietic microenvironment in mouse BM.
A role for CLEC2 as a regulator of macrophage polarity and Kupffer cell polarity, lipid and glucose homeostasis
Data indicate that C-type lectin-like receptor-2 (CLEC-2) is highly expressed on bone marrow megakaryocytes (Mks (zeige MKKS Antikörper)).
Data (including data from studies in transgenic mice) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of Cd36 (zeige CD36 Antikörper)/GPVI (zeige GP6 Antikörper) (glycoprotein VI) and/or Clec-2 (C-type lectin-like receptor-2).
Podoplanin (zeige PDPN Antikörper) and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels.
PI3K and Tec (zeige NR4A3 Antikörper) family kinases play a crucial role in the regulation of platelet activation and Syk (zeige SYK Antikörper) phosphorylation downstream of the CLEC-2 receptor
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\; MIM 602894) and NKG2D (KLRC4\; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000
C-type lectin domain family 1 member B
, C-type lectin-like receptor 2
, C-type lectin-like receptor-2
, C-type lectin domain family 1, member B
, c-type lectin domain family 1 member B-like
, C-type lectin domain containing 9A
, C-type lectin domain family 9 member A