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The protein encoded by BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis.
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Cow (Bovine) Polyclonal BCOR Primary Antibody für ChIP, ELISA - ABIN249965
Tang, Dowbenko, Jackson, Toney, Lewin, Dent, Lasky: The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. in The Journal of biological chemistry 2002
Human Polyclonal BCOR Primary Antibody für ELISA, WB - ABIN565785
Sánchez, Sánchez, Demmers, Rodriguez, Strouboulis, Vidal: Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. in Molecular & cellular proteomics : MCP 2007
Human Polyclonal BCOR Primary Antibody für IP, WB - ABIN4283798
Dietrich, Lerdrup, Landt, Agrawal-Singh, Bak, Tommerup, Rappsilber, Södersten, Hansen: REST-mediated recruitment of polycomb repressor complexes in mammalian cells. in PLoS genetics 2012
Human Polyclonal BCOR Primary Antibody für ELISA, WB - ABIN185043
Huet, Fanget, Jouannot, Meireles, Zeiske, Larochette, Darchen, Desnos: Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Show all 2 Pubmed References
BCOR was negative in all ewing sarcoma family of tumors
BCOR immunohistochemical staining is a highly sensitive marker for YWHAE (zeige YWHAE Antikörper)-NUTM2 high-grade endometrial stromal sarcoma with both classic and unusual morphology and identifies a subset of high-grade endometrial stromal sarcoma with BCOR alterations, including BCOR rearrangement and internal tandem duplication.
the frequent BCOR mutations and the absence of alterations in genes regulating the NF-kappaB (zeige NFKB1 Antikörper) pathway (triple-negative for KLF2 (zeige KLF2 Antikörper), TNFAIP3 (zeige TNFAIP3 Antikörper) and MYD88 (zeige MYD88 Antikörper) mutations) or the absence of a BRAF (zeige BRAF Antikörper) mutation appear to delineate a specific genetic pattern of SDRPL, which is distinct from that already identified in SMZL, HCL or HCL-v.
BCOR internal tandem duplication and/or nuclear immunoreactivity for BCOR or BCL6 (zeige BCL6 Antikörper) can aid in the diagnosis of primitive myxoid mesenchymal tumor of infancy and help to differentiate it from congenital infantile fibrosarcoma.
Case Report: altered BCOR expression and homogeneous coactivation of both the SHH (zeige SHH Antikörper) and WNT (zeige WNT2 Antikörper) signaling pathways, and suggest potential novel therapeutic approaches for patients with a high grade neuroepithelial tumor of the central nervous system with BCOR alteration diagnosis.
Immunohistochemistry for either CCNB3 (zeige CCNB3 Antikörper) or BCOR is not completely sensitive and specific in undifferentiated sarcoma with BCOR-CCNB3 (zeige CCNB3 Antikörper) fusion.
Case Reports: renal sarcomas with BCOR-CCNB3 (zeige CCNB3 Antikörper) gene fusion showing histological overlap with BCOR-related clear cell sarcoma of the kidney.
we report recurrent BCOR exon 16 internal tandem duplications and YWHAE (zeige YWHAE Antikörper)-NUTM2B fusions in half of infantile soft tissue undifferentiated round cell sarcoma and most primitive myxoid mesenchymal tumor of infancy cases, but not in other pediatric sarcomas.
All small blue round cell tumors (SBRCTs) with BCOR-MAML3 (zeige MAML3 Antikörper) and BCOR-CCNB3 (zeige CCNB3 Antikörper) fusions, as well as most with BCOR internal tandem duplications (93%), and all clear cell sarcoma of kidney showed strong and diffuse nuclear BCOR immunoreactivity.
we find that ESS with ZC3H7B (zeige ZC3H7B Antikörper)-BCOR fusion constitutes a novel type of high-grade endometrial stromal sarcoma and shares significant morphologic overlap with myxoid leiomyosarcoma
results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies
Data show that BCL6 interacting corepressor Bcor Is Specifically Down-regulated by Activin (zeige Actbeta Antikörper) Signaling in trophoblast stem cells (TSCs).
T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
IRF8 (zeige IRF8 Antikörper) pairs with BCL6 co-repressor BCOR in the nucleus to enhance its transcriptional repressive activity.
Results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development.
Study isolated an Fbxl10/Jhdm1B (zeige KDM2B Antikörper) complex by Study using a high throughput proteomics approach identified interactors with Rnf2 (zeige RNF2 Antikörper) including Fbxl10/Jhdm1B (zeige KDM2B Antikörper), casein kinase subunits, and the BcoR corepressor
Bcor plays a role in differentiation of multiple tissue lineages during early embryonic development.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.
, BCL-6 interacting corepressor
, BCL6 co-repressor
, Bcl6 interacting corepressor