anti-ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) Antikörper

Human ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) Interaktionspartner

1. A pleckstrin homology domain in PIKE-L directly binds alpha-synuclein and antagonizes its aggregation. Accordingly, PIKE-L overexpression decreases dopaminergic cell death elicited by MPP(+), whereas PIKE-L knockdown elevates alpha-synuclein oligomerization and cell death.

2. these findings support that PIKE amplification or overexpression coordinately acts with CDK4 (zeige CDK4 Antikörper) to drive glioblastoma tumorigenesis.

3. Studies showed that overexpression or mutation of PIKE has been observed in a variety of tumors, promoting cancer cell growth, transformation and invasion through AKT signaling or other signaling pathways, such as focal adhesion kinase. [review]

4. Mutation of Fyn (zeige FYN Antikörper) phosphorylation sites on PIKE-A, depletion of Fyn (zeige FYN Antikörper), or pharmacological inhibition of Fyn (zeige FYN Antikörper) blunts the association between PIKE-A and AMPK (zeige PRKAA1 Antikörper), resulting in loss of its inhibitory effect on AMPK (zeige PRKAA1 Antikörper).

5. expression of PLC-gamma1 (zeige PLCG1 Antikörper) and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma.

6. PIKE reduction rescued PI3K (zeige PIK3CA Antikörper)-dependent and -independent neuronal defects in fragile X (zeige FMR1 Antikörper) syndrome.

7. In this review the CENTG1 gene is amplified in a variety of human cancers which lead to the enhancement of tumor invasion.

8. AGAP2 plays a role in the signalling and recycling of beta2-adrenergic receptors.

9. Fyn (zeige FYN Antikörper) regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a (zeige STAT5A Antikörper)) through enhancing its interaction with the GTPase (zeige RACGAP1 Antikörper) phosphoinositide 3-kinase enhancer A (PIKE-A).

10. PIKE is highly expressed in human squamous cell carcinoma and has a critical role in EGF (zeige EGF Antikörper)-induced squamous cell carcinoma proliferation.

Mouse (Murine) ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) Interaktionspartner

1. Dopamine and DOPAC were not changed in 3-mo-old mice but were decreased at 8 mo in the striatum of PIKE-KO mice compared with wild-type mice. DA and DOPAC in hippocampus and substantia nigra were significantly decreased in 3-mo-old and 8-mo-old PIKE-KO mice as compared with wild-type mice. More severe motor defects in PIKE-KO and Fyn (zeige FYN Antikörper)-KO mice than in wild-type mice exposed to alpha synuclein and MPTP (zeige PTPN2 Antikörper).

2. Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-alpha (zeige TNF Antikörper) on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses.

3. PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) activation.

4. Results demonstrate that the integrity of PIKE signaling is essential for protecting the neurons from excitotoxicity-stimulated damage both in vitro and in vivo.

5. Fyn (zeige FYN Antikörper) regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a (zeige STAT5A Antikörper)) through enhancing its interaction with the GTPase (zeige RACGAP1 Antikörper) phosphoinositide 3-kinase enhancer A (PIKE-A).

6. PIKE is a critical factor in controlling synaptic AMPA (zeige GRIA3 Antikörper) receptor insertion.

7. data established the critical role of PIKE in regulating neuronal survival and development by substantiating the PI3K/Akt (zeige AKT1 Antikörper) pathway.

8. PIKE-A is required for prolactin (zeige PRL Antikörper)-mediated STAT5a (zeige STAT5A Antikörper) activation in mammary gland development.

9. PIKE knockout mice show augmented lipid oxidation, which is accompanied by enhanced AMPK (zeige PRKAA1 Antikörper) phosphorylation in muscle and adipose tissue and is implicated in obesity and diabetes development.

10. PIKE-L acts as a downstream survival effector for netrin-1 (zeige NTN1 Antikörper) through UNC5B (zeige UNC5B Antikörper) in the nervous system