AGAP2 Antikörper (AA 981-1080)

Produktnummer ABIN759971

Der Kaninchen Polyklonal anti-AGAP2 Antikörper wird verwendet zum Nachweis von AGAP2 in Proben von Human. Er wurde validiert für WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro).

Kurzübersicht für AGAP2 Antikörper (AA 981-1080) (ABIN759971)

Target: AGAP2 (ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AGAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-AGAP2 Antikörper

Bindungsspezifität: AA 981-1080

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Centaurin gamma 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu AGAP2

Target: AGAP2 (ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))

Andere Bezeichnung: Centaurin gamma 1

Hintergrund:

Synonyms: Centaurin gamma 1, ANK repeat and PH domain-containing protein 2, AGAP-2, Agap2, Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, AGAP2_HUMAN, ANK repeat and PH domains 2, Arf GAP with GTP binding protein like, Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2, Arf GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2, Arf-GAP with GTPase, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, centaurin gamma1, Centaurin-gamma-1, Centg1, cnt g1, Cnt-g1, Cnt2, GGAP2, GTP binding and GTPase activating protein 2, GTP-binding and GTPase activating protein 2, GTP-binding and GTPase-activating protein 2, Nuclear GTPase PIKE, Phosphatidylinositol-3-kinase enhancer, Phosphoinositide 3 kinase enhancer, PI3K ENHANCER, PIKE.

Background: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.