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The protein encoded by ADH1B is a member of the alcohol dehydrogenase family.
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rs17033 of ADH1B and rs671 of ALDH2 (zeige ALDH2 Antikörper) SNPs were associated with GC risk and smoking habit may further modify the effect of rs671. Conversely, rs4147536 of ADH1B might have a protective role in our study population.
Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group.
ADH1B and CDH1 (zeige CDH1 Antikörper) polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer
The single nuclear polymorphism rs1229984 in ADH1B results in a gain of function and hence an increase in enzyme activity resulting in the production of excess acetaldehyde. It is found in 19-91% of East Asians but in 0-10% of other populations.
Alcohol dehydrogenase 1B (ADH1B) catalyzes the oxidation of alcohol to acetaldehyde.
Men carrying the ADH1B rs1229984 G>A polymorphism consumed significantly less alcohol than non-carriers.
study demonstrates that ADH1B*3 may protect college students of African descent against alcohol outcomes, although only in low alcohol-facilitating environments.
In Japanese alcoholic men, ADH1B*1/*1 genotype increased the risk of thrombocytopenia.
In analysis using the ADH1B and ADH1C genotypes as instrumental variables for alcohol consumption, the hazards ratio for atrial fibrillation per genetic drink per day was 0.79 (0.44-1.41) among men and 0.64 (0.12-3.42) among women
enhanced Alcohol elimination rate in ADH1B*2 carriers and the increased salivary Acetaldehyde levels in ALDH2 (zeige ALDH2 Antikörper)*1/*2 carriers among intoxicated alcoholics provide possible mechanisms explaining how each genetic polymorphism a ff ects the risk of alcoholism and upper aerodigestive tract cancer.
The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
alcohol dehydrogenase 2
, alcohol dehydrogenase
, ADH, beta subunit
, alcohol dehydrogenase 1B
, alcohol dehydrogenase 2 (class I), beta polypeptide
, alcohol dehydrogenase subunit beta
, aldehyde reductase
, alcohol dehydrogenase (class I), beta polypeptide
, alcohol dehydrogenase 2 (subunit B)
, alcohol dehydrogenase IB (class I), beta polypeptide