anti-ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2) Antikörper

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking.

Alle Antikörper anzeigen Gen GeneID UniProt
ARFGEF2 99371  
ARFGEF2 296380  
ARFGEF2 10564 Q9Y6D5
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF, ELISA, WB Western blot analysis of extracts from A549 cells, using ARFGEF2 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of A549 cells, using ARFGEF2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
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Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: ARFGEF2 Antibody [NBP1-88607] - Immunohistochemical staining of human small intestine shows distinct cytoplasmic positivity in glandular cells. Western Blot: ARFGEF2 Antibody [NBP1-88607] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10.Lane 2: CACO-2 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
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Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
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Human Kaninchen Unkonjugiert IF, IHC (p), WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
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Human Kaninchen Unkonjugiert ELISA, IF, WB   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$458.77
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Human Kaninchen Unkonjugiert IF, IHC (p), WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$522.50
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Human Kaninchen Cy5 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Cy5.5 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Cy7 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen FITC IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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ARFGEF2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine) , ,


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Rat (Rattus) , ,


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Am meisten referenzierte anti-ARFGEF2 Antikörper

  1. Human Polyclonal ARFGEF2 Primary Antibody für ICC, IF - ABIN4281377 : Christis, Munro: The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. in The Journal of cell biology 2012 (PubMed)

Weitere Antikörper gegen ARFGEF2 Interaktionspartner

Mouse (Murine) ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2) Interaktionspartner

  1. coordinated interactions between actin (through FlnA (zeige FLNA Antikörper)) and vesicle trafficking (through Big2-Arf (zeige CDKN2A Antikörper)) direct the assembly and disassembly of membrane protein complexes required for neuronal migration and neuroependymal integrity.

  2. an early acting GEF (zeige ARHGEF2 Antikörper) (GBF1 (zeige PTGES2 Antikörper)) activates ARFs that mediate recruitment of late acting GEFs (BIG1 (zeige CNTN3 Antikörper)/2) to coordinate coating events within the pre-Golgi/Golgi/TGN (zeige TG Antikörper) continuum.

  3. Big2 inhibition promotes Filamin A (zeige FLNA Antikörper) phosphorylation, thereby disrupting cell intrinsic neuronal migration.

  4. Results indicate that murine BIG2 is essential for early embryonic development.

Human ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2 (Brefeldin A-Inhibited) (ARFGEF2) Interaktionspartner

  1. Both phospholipase D (zeige PLD Antikörper) activity and vesicular trafficking were required for effects of BIG1 (zeige CNTN3 Antikörper) and BIG2 on beta-catenin (zeige CTNNB1 Antikörper) activation. Levels of PKA-phosphorylated beta-catenin (zeige CTNNB1 Antikörper) S675 and beta-catenin (zeige CTNNB1 Antikörper) association with PKA, BIG1 (zeige CNTN3 Antikörper), and BIG2 were also diminished after BIG1 (zeige CNTN3 Antikörper)/BIG2 depletion.

  2. Description of a novel ARFGEF2 mutation in five related patients presenting with West syndrome, microcephaly, periventricular heterotopia and thin corpus callosum.

  3. The clinical phenotype associated with mutations in ARFGEF2 is relatively homogeneous in the families report.

  4. Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.

  5. an early acting GEF (zeige SLC2A4RG Antikörper) (GBF1 (zeige GBF1 Antikörper)) activates ARFs that mediate recruitment of late acting GEFs (BIG1 (zeige CNTN3 Antikörper)/2) to coordinate coating events within the pre-Golgi/Golgi/TGN (zeige TG Antikörper) continuum.

  6. Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin beta1 cycling and actin remodeling.

  7. Up-regulation of ARFGEF2 is associated with the Huntington's disease.

  8. BIG1 (zeige CNTN3 Antikörper) and BIG2 have roles in endomembrane organization

  9. BIG2 and Exo70 (zeige EXOC7 Antikörper) interact in trans-Golgi network and centrosomes, as well as in exocyst structures or complexes that move along microtubules to the plasma membrane.

  10. ARFGEF2 mRNA was widely expressed in all cortical layers, especially in the neural precursors of the ventricular and subventricular zones during development, with persistent but diminished expression in adulthood.

ARFGEF2 Antigen-Profil

Protein Überblick

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.

Genbezeichner und Symbole assoziert mit ARFGEF2

  • ADP ribosylation factor guanine nucleotide exchange factor 2 (ARFGEF2) Antikörper
  • ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (Arfgef2) Antikörper
  • ADP ribosylation factor guanine nucleotide exchange factor 2 (Arfgef2) Antikörper
  • AI463430 Antikörper
  • AW493672 Antikörper
  • Big2 Antikörper
  • dJ1164I10.1 Antikörper
  • E230011G24Rik Antikörper
  • PVNH2 Antikörper

Bezeichner auf Proteinebene für ARFGEF2

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) , cytohesin 1-like , brefeldin A-inhibited GEP 2 , brefeldin A-inhibited guanine nucleotide-exchange protein 2 , Brefeldin A-inhibited guanine nucleotide-exchange factor 2

GENE ID SPEZIES
419211 Gallus gallus
477256 Canis lupus familiaris
539295 Bos taurus
743923 Pan troglodytes
99371 Mus musculus
296380 Rattus norvegicus
10564 Homo sapiens
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