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ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking.
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Human Polyclonal ARFGEF2 Primary Antibody für ICC, IF - ABIN4281377
Christis, Munro: The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2. in The Journal of cell biology 2012
coordinated interactions between actin (through FlnA) and vesicle trafficking (through Big2-Arf) direct the assembly and disassembly of membrane protein complexes required for neuronal migration and neuroependymal integrity.
an early acting GEF (zeige ARHGEF2 Antikörper) (GBF1 (zeige PTGES2 Antikörper)) activates ARFs that mediate recruitment of late acting GEFs (BIG1 (zeige CNTN3 Antikörper)/2) to coordinate coating events within the pre-Golgi/Golgi/TGN (zeige TG Antikörper) continuum.
Big2 inhibition promotes Filamin A (zeige FLNA Antikörper) phosphorylation, thereby disrupting cell intrinsic neuronal migration.
Results indicate that murine BIG2 is essential for early embryonic development.
Both phospholipase D (zeige PLD Antikörper) activity and vesicular trafficking were required for effects of BIG1 (zeige CNTN3 Antikörper) and BIG2 on beta-catenin (zeige CTNNB1 Antikörper) activation. Levels of PKA-phosphorylated beta-catenin (zeige CTNNB1 Antikörper) S675 and beta-catenin (zeige CTNNB1 Antikörper) association with PKA, BIG1 (zeige CNTN3 Antikörper), and BIG2 were also diminished after BIG1 (zeige CNTN3 Antikörper)/BIG2 depletion.
Description of a novel ARFGEF2 mutation in five related patients presenting with West syndrome, microcephaly, periventricular heterotopia and thin corpus callosum.
The clinical phenotype associated with mutations in ARFGEF2 is relatively homogeneous in the families report.
Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.
an early acting GEF (zeige SLC2A4RG Antikörper) (GBF1 (zeige GBF1 Antikörper)) activates ARFs that mediate recruitment of late acting GEFs (BIG1 (zeige CNTN3 Antikörper)/2) to coordinate coating events within the pre-Golgi/Golgi/TGN (zeige TG Antikörper) continuum.
Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin beta1 cycling and actin remodeling.
Up-regulation of ARFGEF2 is associated with the Huntington's disease.
BIG1 (zeige CNTN3 Antikörper) and BIG2 have roles in endomembrane organization
BIG2 and Exo70 (zeige EXOC7 Antikörper) interact in trans-Golgi network and centrosomes, as well as in exocyst structures or complexes that move along microtubules to the plasma membrane.
ARFGEF2 mRNA was widely expressed in all cortical layers, especially in the neural precursors of the ventricular and subventricular zones during development, with persistent but diminished expression in adulthood.
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
, cytohesin 1-like
, brefeldin A-inhibited GEP 2
, brefeldin A-inhibited guanine nucleotide-exchange protein 2
, Brefeldin A-inhibited guanine nucleotide-exchange factor 2