anti-ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Antikörper

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Zusätzlich bieten wir Ihnen ADAMTS5 Kits (43) und ADAMTS5 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ADAMTS5 23794 Q9R001
ADAMTS5 11096 Q9UNA0
ADAMTS5 304135  
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Showing 10 out of 121 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NBP2-15286] - Paraffin-embedded Hepatoma, using antibody at 1:500 dilution. Western Blot: ADAMTS5 Antibody [NBP2-15286] - Sample (30 ug of whole cell lysate) A: HeLa B: HepG2 7. 5% SDS PAGE, antibody diluted at 1:3000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Maus Kaninchen Unkonjugiert WB Western blot analysis of anti-ADAMTS5 Antibody (Center) (ABIN391652) in mouse muscle tissue lysates (35 µg/lane). ADAMTS5(arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xenograft, using ADAMTS5, antibody at 1:100 dilution. WB Image Sample (30 ug of whole cell lysate) A: JC 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048292 IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Fledermaus Kaninchen Unkonjugiert IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048295 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Hamster Kaninchen Unkonjugiert IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048293 IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048294 IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Anti-ADAMTS5 antibody  ABIN1048296 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-ADAMTS5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert WB   100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of anti-ADAMTS5 Antibody (Center) in mouse muscle tissue lysates (35ug/lane). ADAMTS5(arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details

ADAMTS5 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen ADAMTS5 Interaktionspartner

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Interaktionspartner

  1. Energy expenditure and thermogenesis were not significantly different between KO and WT ADAMTS5-J mice (in contrast to somewhat enhanced levels in ADAMTS5-P mice). Insulin (zeige INS Antikörper) sensitivity was improved in the ADAMTS5-J KO mice, and they were protected against non-alcoholic steatohepatitis in the DIO model

  2. Adamts5(-/-) mice were protected from hepatic mitochondrial dysfunction, as indicated by increased mitochondrial respiratory chain complex activity, higher ATP levels and higher expression of antioxidant enzymes. Absence of ADAMTS5 preserves liver integrity in a diet-induced obesity model.

  3. research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality

  4. TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (zeige ACAN Antikörper) and Vcan (zeige Vcan Antikörper) by an ADAMTS (zeige ADAMTS1 Antikörper) other than TS5.

  5. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (zeige ADAMTS4 Antikörper) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  6. aggrecan (zeige ACAN Antikörper) and brevican (zeige BCAN Antikörper) proteolysis is compensated in Adamts4 (zeige ADAMTS4 Antikörper)-/- or Adamts5-/- mice by ADAMTS (zeige ADAMTS1 Antikörper) proteoglycanase (zeige MMP3 Antikörper) family members but a threshold of versican (zeige Vcan Antikörper) proteolysis is sensitive to the loss of a single ADAMTS (zeige ADAMTS1 Antikörper) proteoglycanase (zeige MMP3 Antikörper) during spinal cord injury

  7. The present study reveals ADAMT-5 expression by mast cells(MCs (zeige SMCP Antikörper)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  8. Western blot analyses indicated that aggrecanase (zeige ADAMTS4 Antikörper)-generated proteoglycan (zeige Vcan Antikörper) fragments are produced after SCI.

  9. RelA/p65 (zeige NFkBP65 Antikörper) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.

  10. Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Interaktionspartner

  1. A novel genetic variant in ADAMTS5 is associated with bicuspid aortic valve disease.

  2. expression by synovial cells induced by hemoglobin at low doses, suggesting a possible role for hemoglobin in cartilage damage after intra-articular hemorrhage

  3. The SNPs rs1337185 in COL11A1 (zeige COL11A1 Antikörper) and rs162509 in ADAMTS5 are associated with susceptibility to lumbar disc degeneration. The C allele of rs1337185 is risky for patients who are affected by lumbar pathologies such as disc herniation, stenosis and spondylolisthesis. The G allele of rs16250 represents a risk factor for the development of disc herniation.

  4. ADAMTS5 is hypermethylated and inhibits cancer cells invasion and migration in colorectal cancer, and correlates with OS and DFS (zeige FST Antikörper).

  5. Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1 (zeige LRP1 Antikörper).

  6. MMP-13 (zeige MMP13 Antikörper) may play a role on physiological turnover of cartilage extracellular matrix and that LRP1 (zeige LRP1 Antikörper) is a key modulator of extracellular levels of MMP-13 (zeige MMP13 Antikörper) and its internalization is independent of the levels of ADAMTS-4 (zeige ADAMTS4 Antikörper), -5 and TIMP-3 (zeige TIMP3 Antikörper).

  7. The IL1B (zeige IL1B Antikörper)/AP-1 (zeige FOSB Antikörper)/miR (zeige MLXIP Antikörper)-30a/ADAMTS-5 axis regulates cartilage matrix degradation in osteoarthritis.

  8. The findings suggest that miR (zeige MLXIP Antikörper)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5 (zeige IGFBP5 Antikörper).

  9. Results provide direct evidence indicating that Fibulin-2 (zeige FBLN2 Antikörper) is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 (zeige FBLN2 Antikörper) and the ADAMTSs metalloproteases.

  10. Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5, MMP13 (zeige MMP13 Antikörper), and decreased COL2A1 (zeige COL2A1 Antikörper) expression.

Cow (Bovine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Interaktionspartner

  1. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (zeige ADAMTS4 Antikörper)) explains the minor contribution of the MMP enzymes to aggrecan (zeige ACAN Antikörper) catabolism in vivo.

  2. ADAMTS4 (zeige ADAMTS4 Antikörper) and ADAMTS5 are inhibited by alpha2-macroglobulin (zeige A2M Antikörper)

  3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (zeige ADAMTS4 Antikörper) and ADAMTS-5

  4. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

ADAMTS5 Antigen-Profil

Protein Überblick

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Genbezeichner und Symbole assoziert mit ADAMTS5

  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) Antikörper
  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (adamts5) Antikörper
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5) Antikörper
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5) Antikörper
  • 9530092O11Rik Antikörper
  • ADAM-TS5 Antikörper
  • ADAM-TS 5 Antikörper
  • ADAM-TS 11 Antikörper
  • ADAMTS-5 Antikörper
  • ADAMTS-11 Antikörper
  • ADAMTS1 Antikörper
  • ADAMTS11 Antikörper
  • ADMP-2 Antikörper
  • AI481094 Antikörper
  • ASMP-2 Antikörper

Bezeichner auf Proteinebene für ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5 , a disintegrin and metalloproteinase with thrombospondin motifs 5-like , A disintegrin and metalloproteinase with thrombospondin motifs 5 , ADAM-TS 5 , ADAMTS-5 , ADMP-2 , aggrecanase-2 , implantin , a disintegrin and metalloproteinase with thrombospondin motifs 11 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM-TS5 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GENE ID SPEZIES
100091913 Ornithorhynchus anatinus
100441162 Pongo abelii
100488158 Xenopus (Silurana) tropicalis
100552915 Anolis carolinensis
23794 Mus musculus
11096 Homo sapiens
100522952 Sus scrofa
286805 Bos taurus
304135 Rattus norvegicus
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