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ADAMTS17 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Zusätzlich bieten wir Ihnen ADAM Metallopeptidase with thrombospondin Type 1 Motif, 17 Kits (13) und und viele weitere Produktgruppen zu diesem Protein an.
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Secretion of ADAMTS17 requires O-fucosylation. ADAMTS17 binds fibrillin-2 but not fibrillin-1 and does not cleave either. ADAMTS17 regulates fibrillin isoform composition of microfibrils in the eye.
higher Adamts17 expression is found in several human cancer cell subtypes, especially in breast ductal carcinoma and there is an inverse correlation between higher Adamts17 expression and patients' survival.
A mutation in WMS-like gene ADAMTS17 also causes WMS.
Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition.
Recessive ADAMTS17 mutations are a recurrent cause of isolated spherophakia with short stature.
ADAMTS17 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Homozygous mutation in ADAMTS17 causes lenticular myopia, ectopia lentis, glaucoma, spheropakia, and short stature.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined.
ADAM metallopeptidase with thrombospondin type 1 motif, 17
, disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17
, A disintegrin and metalloproteinase with thrombospondin motifs 17
, ADAM-TS 17
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17
, A disintegrin and metalloproteinase with thrombospondin motifs 17-like