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ADAMTS17 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family.
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higher Adamts17 expression is found in several human cancer cell subtypes, especially in breast ductal carcinoma and there is an inverse correlation between higher Adamts17 expression and patients' survival.
A mutation in WMS (zeige FBN1 Antikörper)-like gene ADAMTS17 also causes WMS (zeige FBN1 Antikörper).
Endothelial protease nexin-1 (zeige SERPINE2 Antikörper) is a novel regulator of A disintegrin and metalloproteinase 17 (zeige ADAM17 Antikörper) maturation and endothelial protein C receptor (zeige PROCR Antikörper) shedding via furin (zeige FURIN Antikörper) inhibition.
Recessive ADAMTS17 mutations are a recurrent cause of isolated spherophakia with short stature.
ADAMTS17 is a target gene of the BACH1 (zeige BACH1 Antikörper) transcription factor according to ChIP-seq analysis in HEK (zeige EPHA3 Antikörper) 293 cells.
Homozygous mutation in ADAMTS17 causes lenticular myopia, ectopia lentis, glaucoma, spheropakia, and short stature.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined.
ADAM metallopeptidase with thrombospondin type 1 motif, 17
, disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17
, A disintegrin and metalloproteinase with thrombospondin motifs 17
, ADAM-TS 17
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17
, A disintegrin and metalloproteinase with thrombospondin motifs 17-like