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STAT4 Antikörper (pTyr693)

STAT4 Reaktivität: Human, Maus WB Wirt: Maus Monoclonal 38-p unconjugated
Produktnummer ABIN968925
  • Target Alle STAT4 Antikörper anzeigen
    STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))
    Bindungsspezifität
    • 37
    • 11
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr693
    Reaktivität
    • 92
    • 57
    • 36
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 96
    • 11
    • 2
    • 2
    Maus
    Klonalität
    • 87
    • 24
    Monoklonal
    Konjugat
    • 56
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser STAT4 Antikörper ist unkonjugiert
    Applikation
    • 80
    • 48
    • 41
    • 24
    • 23
    • 16
    • 13
    • 13
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Maus
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Phosphorylated Human Stat4 (pY693)
    Klon
    38-p
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product STAT4 Primärantikörper
  • Kommentare

    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Kisseleva, Bhattacharya, Braunstein, Schindler: "Signaling through the JAK/STAT pathway, recent advances and future challenges." in: Gene, Vol. 285, Issue 1-2, pp. 1-24, (2002) (PubMed).

    Visconti, Gadina, Chiariello, Chen, Stancato, Gutkind, OShea: "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity." in: Blood, Vol. 96, Issue 5, pp. 1844-52, (2000) (PubMed).

  • Target
    STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))
    Andere Bezeichnung
    Stat4 (STAT4 Produkte)
    Synonyme
    SLEB11 antikoerper, signal transducer and activator of transcription 4 antikoerper, STAT4 antikoerper, stat4 antikoerper, Stat4 antikoerper
    Hintergrund
    The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNgamma in response to treatment with IL-12. IFNgamma plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.
    Molekulargewicht
    89 kDa
    Pathways
    JAK-STAT Signalweg
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