CDKN2B Antikörper (Middle Region)

Produktnummer ABIN926911

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CDKN2B in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund, Rind (Kuh) und Schwein.

Kurzübersicht für CDKN2B Antikörper (Middle Region) (ABIN926911)

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKN2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDKN2B Antikörper

Bindungsspezifität: Middle Region

Kreuzreaktivität: Maus, Ratte (Rattus), Rind (Kuh), Schwein, Hund

Aufreinigung: Purified

Immunogen: CDKN2 B antibody was raised in rabbit using the middle region of CDKN2 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

CDKN2B Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this CDKN2B antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu CDKN2B

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Andere Bezeichnung: CDKN2B

Hintergrund: CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Synonyms: Polyclonal CDKN2B antibody, Anti-CDKN2B antibody, cyclin-dependent kinase inhibitor 2B, p15, inhibits CDK4 antibody.

Pathways: Zellzyklus, Mitotic G1-G1/S Phases