TNFSF9 Antikörper (C-Term)

Produktnummer ABIN926741

Der Kaninchen Polyklonal anti-TNFSF9 Antikörper wird verwendet zum Nachweis von TNFSF9 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für TNFSF9 Antikörper (C-Term) (ABIN926741)

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNFSF9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TNFSF9 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified

Immunogen: TNFSF9 antibody was raised in rabbit using the C terminal of TNFSF9 as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

TNFSF9 Blocking Peptide, (ABIN5616714), is also available for use as a blocking control in assays to test for specificity of this TNFSF9 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu TNFSF9

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Andere Bezeichnung: TNFSF9

Hintergrund: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. Synonyms: Polyclonal TNFSF9 antibody, Anti-TNFSF9 antibody, tumor necrosis factor, ligand superfamily, member 9 antibody, 4-1BB-L antibody, CD137L antibody.

Pathways: Activated T Cell Proliferation, Cancer Immune Checkpoints